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Zinc - Europe PMC

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Last Updated: 24 June 2022

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Pulmonary delivery of resveratrol- β -cyclodextrin inclusion complexes for the prevention of zinc chloride smoke-induced acute lung injury.

Smoke bombs are often used in military/fire training, as they can produce a substantial amount of zinc chloride fumes. Inhalation of ZnCl 2 smoke leads to acute lung injury that would almost lead to acute respiratory distress syndrome. In this research, an inhalable RES formulation consisting of RES-u03b2 cyclodextrin inclusion complexes was designed to combat ZnCl 2 smoke-induced ALI. The Res-u03b2 -CD powders had a small mass median aerodynamic diameter of 3. 61 % bcm and a 38. 84% fine particle percentage, making them suitable for pulmonary inhalation. CD protected the respiratory system, percutaneous oxygen saturation, physical fitness, lung capillary stability, and lung liquid balance, relieving inflammation and apoptosis, according to u03b2 - CD. In conclusion, the pulmonary delivery of RES-u03b2 - CD by direct lung drug delivery and monitoring immune balance is a promising anti-inflammatory and anti-apoptosis drug for the prevention of ZnCl 2 smoke-induced ALI.

Source link: https://europepmc.org/article/MED/35380089


Antibacterial activity of nano zinc oxide green-synthesised from Gardenia thailandica triveng. Leaves against Pseudomonas aeruginosa clinical isolates: in vitro and in vivo study.

Metal nanoparticles are antibacterial agents and may help solve the issue of antibiotic resistance. We used Gardenia thailandica methanol extract to biogenically synthe zinc oxide nanoparticles herein. In vitro and in vivo against Pseudomonas aeruginosa clinical isolates, the antibacterial activity of ZnO-NPs was investigated both in vitro and in vivo. The in vivo study was carried out, revealing a protective role of ZnO-NPs against the deleterious effects of P. aeruginosa bacteria on lung, liver, and kidney tissue. GTME, which has a promising antibacterial activity, is a good source for ZnO-NPs.

Source link: https://europepmc.org/article/MED/35361019


The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of Enterococcus faecalis virulence.

Here, we show that the E. faecalis encoded ABC-type transporter AdcACB and an orphanage-binding lipoprotein AdcAIIIIIII who collaborately to protect Zn homeostasis. Simultaneous inactivation of adcA and adcAIII, or the entire adcACB operon resulted in a significant decrease in intracellular Zn under Zn-controlled conditions and increased sensitivity to Zn-chelating agents including human calprotectin, aberrant cell morphology, and impaired fitness in serum ex vivo. We also showed that the AdcACB/AdcII system contributes to E. faecalis virulence in a Galleria mellonella invertebrate infection model and two catheter-associated mouse infection models that recapitulate several of the host conditions associated with enterococcal human infections. This research concludes that high-affinity Zn import is vital for the pathogenesis of E. faecalis, as well as the surface-associated AdcA and AdcAII lipoproteins as potential therapeutic targets.

Source link: https://europepmc.org/article/MED/35341449


Magnesium and Zinc Intake Ratio Mediates the Increase of Coronary Artery Calcification through Upregulating Interleukin 6.

The connection between dietary minerals and coronary artery calcification has been emphasized. However, the effects of multiple dietary minerals on CAC progression remain unclear. The effect of combined dietary mineral intake on CAC increases is unclear, according to this report. In the follow-up to the baseline exam, increased CAC scores were established, Then, the progression of CAC was shown by rising CAC scores. The results revealed that the dietary intake of individual minerals showed no significant differences in CAC progression vs. non progress groups. However, participants with CAC had an elevated Magnesium :Zinc ratio, as reported by CAC members. The increased risk of CAC associated with Mg/Zn was mitigated by an increase in IL-6, which was linked to an increase in Mg: Zn ratios. Thus, the analysis of combined dietary intake of Zn and Mg could play a cardio protective role among CAC patients.

Source link: https://europepmc.org/article/MED/35289237


DNA methylation-mediated expression of zinc finger protein 615 affects embryonic development in Bombyx mori .

In Bombyx mori, we investigated the effects of DNA methylation on early embryonic development. Early embryo methylation events mostly occurred in the 5' area of protein metabolism-related genes, according to Genome methylation and transcriptome analysis. The transcription factor gene zinc finger protein 615 was methylated by DNA methyltransferase 1 to be up-regulated and bind to protein metabolism-related genes. Through ZnF615, DNA methylation mainly controlled the expression of nonmethylated nutrient metabolism-related genes. The hatching rate and egg number of hatching eggs in ZnF615 were reduced by CRISPR/Cas9 gene editing, which was similar to that of a DnM1 knockout knockout. The DNA methylation pattern in the parent ovary was maintained and doubled in the offspring embryo, according to the ZnF615 methylation rate.

Source link: https://europepmc.org/article/MED/35616260


Pegylated metal-free and zinc(II) phthalocyanines: synthesis, photophysicochemical properties and in vitro photodynamic activities against head, neck and colon cancer cell lines.

In this research, a series of peripherally and non-peripherally tetra-substituted metal-free and zinc phthalocyanines were successfully produced in good yields by cyclotetramerization of the phthalonitrile derivative bearing a tetraethylene glycol ether group at 3- and 4-positions were found in good yields. When comparing their singlet oxygen generation capabilities, metallophthalocyanine derivatives with zinc had a higher singlet oxygen yield than metal-free derivatives in DMSO. Of the four molecules tested, the highest photodynamic activity was found in 1b and 2b molecules with a metal core.

Source link: https://europepmc.org/article/MED/35734907


Dual intercalation of inorganics-organics for synergistically tuning the layer spacing of V 2 O 5 · n H 2 O to boost Zn 2+ storage for aqueous zinc-ion batteries.

layered vanadium oxides, as cathode materials for aqueous rechargeable zinc-ion batteries, have excelled as a 2D zinc-ion transport channel. A one-step hydrothermal process was used in the present study, where Mg 2+ and polyaniline were simultaneously introduced into the layers of hydrated V 2 O 5 in which a "co-intercalation system" was investigated and investigated. PANI's zinc-storage capacity is present, and Mg 2+ intercalated with PANI can increase the conductivity of the material and increase its stability.

Source link: https://europepmc.org/article/MED/35678364


Fabrication of zinc-loaded silicon carbide nanocomposite for in vitro cell viability and in vivo wound dressing care.

Aim In this review, Zinc-silicon carbide powders were manufactured in a simple way by using Zn nanoparticles coated on silicon carbide with enhanced antibacterial and healing activity. A percentage decrease in the wound was determined during in vivo wound healing. Zn-SiC NPs have 54. 6 nm mean particle size, with -15. 9 nm maximum potential, 0. 05 u00b1 0. 05 polydispersity index, -15. 9 mV zeta potential, with 0. 187 u00b1 0. 05 polydispersity index, u00b1 0. 05 0. 05 nm mean particle size, -15. 9 mV zeta potential, 5. 25 zeta u00b1 zeta u00b1 zeta potential, zeta potential, zeta potential, zeta potential with zeta potential with zeta potential with 0. 05 0. 05 zeta potential with u00b1 zeta potential with 0. 05 zeta 0. 05 0. 05 zeta u00b1 zeta potential with After the caesarean section, these results point to the likelihood of using these Zn particles embedded on SiC NPs as a promising wound healing agent.

Source link: https://europepmc.org/article/MED/35670223


A home-made sampling system coupled to hectowatt-MPT mass spectrometry in positive ion mode to confirm target ions of copper and zinc from Poyang Lake, China.

To analyze samples of Poyang Lake, China, we report the establishment of a new HN-HMPT-MS for metal elements assay based on environmental water. The general dimensional shape of target ions is [M x y z ] + in the positive ion mode, according to a detailed multi-stage tandem mass spectra study. The method with linear coefficients of 0. 9709 - 0. 99962 for copper and zinc testing was in accordance with that of ICP-MS. For the method with linear response ranges of about 4 orders of magnitude, the magnitude corresponding to that of ICP-MS was within a range of approximately 4 orders of magnitude. Except for the recovery of 79% for the third sample and 123. 8% for the seventh sample, the present method also produced good recoveries in spiked ten batches of drinking water samples.

Source link: https://europepmc.org/article/MED/35732744


The C2H2-type zinc finger protein PhZFP1 regulates cold stress tolerance by modulating galactinol synthesis in Petunia hybrida.

The C2H2 zinc finger proteins play an important role in controlling cold stress responses. However, the connection between C2H2 functions and raffinose synthesis in cold tolerance remains unclear. We present here the characterization of the cold-induced zinc finger protein PhZFP1 in Petunia hybrida. In PhZFP1-overexpressing plants and decreased in PhZFP1-RNAi plants under cold stress, the accumulation of galactinol and raffinose, as well as PhGolS1-1 transcripts, was markedly elevated in galactinol and raffinose, as well as increased in PhZFP1-overexpressing plants and reduced in PhZFP1-RNAi plants under cold stress. This research has also provided new insight into the mechanisms that underpin C2H2-mediated cold stress tolerance, as well as a candidate gene for increasing cold stress tolerance.

Source link: https://europepmc.org/article/MED/35726094

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions