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Zika Virus - Springer Nature

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Last Updated: 09 September 2022

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Identification of potential inhibitors of Zika virus targeting NS3 helicase using molecular dynamics simulations and DFT studies

Despite the numerous research trials into Zika virus treatment's drug discovery program, no antiviral drugs or vaccines have yet to be found. Due to increased global travel, the mosquito vector and ZIKV infection transmission is predicted to rise globally. An NS3-Hel protein makes it an attractive target for designing novel drugs for ZIKV therapy. The results of a molecular dynamics simulation results show dynamic stability between protein and ligand complexes, and the binding sites remained relatively unchanged during the simulation period.

Source link: https://doi.org/10.1007/s11030-022-10522-5


Zika Virus Strains and Dengue Virus Induce Distinct Proteomic Changes in Neural Stem Cells and Neurospheres

During the microcephaly epidemic in Brazil in 2016, several disorders and congenital malformations have been traced to the circulating Zika virus strain; however, the molecular mechanisms behind several of these changes and distinct viral molecular targets have not been fully understood. Neural stem cells isolated from induced pluripotent stem cells were cultured both as monolayers and in suspension, and then infected with ZIKV or DENV to examine neural cell differentiation.

Source link: https://doi.org/10.1007/s12035-022-02922-3


Early infection of Zika virus in the male reproductive system of AG129 mice: molecular and immunohistochemical evaluation

Several concerns regarding how and where it circulates in the male reproductive system have been raised since the Zika virus Virus, an important arbovirus, and the virus persistence in semen. At two dpi, we investigated ZIKV's interactions with mouse MRS using the AG129 strain, a ZIKV permissive immunodeficient mouse strain. Understanding the early stages of ZIKV infection in MRS may help with current knowledge of the condition and support the development of treatments specific to the infection at this site.

Source link: https://doi.org/10.1007/s42770-022-00761-x


TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation

Background The recognition of viral infection by aninnate antiviral immune system contributes to the production of the type I interferon and proinflammatory signaling pathways. Results We have discovered that the TRIM22 has been highly restricted both transcriptionally and translationally on Zika virus infections, as shown here. A variety of health signs in humans include mild to moderate infections, as well as abnormal fetal brain development. Overexpression of TRIM22 protein stifled ZIKV growth, however deletion of TRIM22 in host cells increased ZIKV infectivity. TRIM22, a fully functioning E3 ubiquitin ligase, promoted the ubiquitination and degradation of ZIKV nonstructural protein 1 and nonstructural protein 3 as a neostructural protein 3. In addition, we discovered that TRIM22 prevented other flavivirus infections, including dengue virus and yellow fever virus. Conclusion: TRIM22 is an ISG with a major role in host defense against flaviviruses by binding and degrading of the NS1 and NS3 proteins, according to the TS1 and NS3 proteins.

Source link: https://doi.org/10.1186/s13578-022-00872-w

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions