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In 2016, Zika virus was designated as a Public Health Emergency of International Concern. There is limited data on ZIKV vaccine acceptability around the world, but there is no research pertaining to Latin American countries. Methods: Between January and November 2019, 429 undergraduate students at ESPOL responded anonymously to a ZIKV vaccine poll. Testing found correlations between the likelihood of receiving a ZIKV vaccine and socioeconomic, ZIKV study, ZIKV psychosocial variables, and ZIKV information source variables. Most respondents reported being neutral or likely to receive a ZIKV vaccine, regardless of their compliance with ZIKV study findings regarding behavior and psychosocial characteristics, according to bivariate findings, the majority of respondents reported being neutral or unlikely to receive a ZIKV vaccine. Conclusions: This report provides insight into ZIKV awareness among ESPOL university students and reveals that the majority of respondents obtained ZIKV related information from television. Vaccine hesitancy was the most common reason for not wanting to receive a hypothetical ZIKV vaccine.
Source link: https://doi.org/10.1016/j.jvacx.2022.100258
Zika virus is a Flaviviridae virus and a single strand RNA virus with a high incidence in the Philippines. ZIKV infection can cause a mild infection to the mother but can also be vertically transmitted to the developing fetus, causing congenital anomalies. This review article summarizes the latest findings on ZIKV transmission and diagnosis, as well as the use of nutraceuticals to shield against the ZIKV virus. In the placental trophoblasts, we also investigate the mechanism of ZIKV-induced endoplasmo and apoptosis, as well as the protective role of palmitoleate against ZIKV-induced ER stress and apoptosis.
Source link: https://doi.org/10.3390/nu15010124
Although nearly 80% of ZIKV infections are symptomatic and mild, several studies have established a correlation between ZIKV and chronic illnesses such as Microcephaly and Guillain Barru00e9 Syndrome. Both a vector-borne and sexually transmitted disease epidemic, as well as the degree of under-reporting are among the study's objectives. Using the model, we find that eliminating disease prevention by targeting the sexual pathway alone has negligible effect on overall spread, but if the percentage of risky sexual activity rises, it could become significant. These findings may be helpful to public health agencies and governments to develop and implement appropriate health care policies and minimize the Zika outbreak's impact.
Source link: https://doi.org/10.1371/journal.pone.0270127
Elevations in IFNu03b2 were recorded in acute patients of the majority of cell types and were statistically elevated in 31 of 36 cell subsets. We quantified response to in vitro Zika virus infection in vitro with dengue or Zika viruses and found a similar pattern of upregulation of responses to Zika virus infection by innate cell types that was not present in response to dengue virus. Despite concurrent dengue fever, patient cells enriched innate cell responses to Zika virus, raising public health issues and enhancing anti-Zika response, indicating a robust and robust anti-Zika response amid persistent dengue disease.
Source link: https://doi.org/10.1371/journal.pntd.0008112
However, Moso in the wild is not exposed to constant temperatures or constant temperatures, but it is confronted with temperature fluctuations on a daily basis. MethodsIn the current study, the mosquito life cycle and Zika virus transmission efficiency were investigated. The oviposition and persistence of the infected mosquitoes and hatching rate, larvae growth cycle, and progeny mosquito infection rates were all significantly different from those under constant temperatures. In comparison to the low-temperature group, larvae mosquitoes in DTR grew faster and adult mosquitoes carried a higher Zika viral RNA load.
Source link: https://doi.org/10.3389/fmicb.2022.1075362
The Americas have developed and spread a strain of Zika virus of Asian origin associated with birth defects and neurological disorders. ZIKV was first isolated in the blood of nonhuman primates in Africa and has been found in the blood, saliva, and urine of a few catarrhine species in both Africa and Asia, indicating that nonhuman primates can act as both a source and a reservoir of the virus. We introduce a protocol for ZIKV detection in noninvasively collected fecal samples of a Neotropical primate. Fecal samples were obtained from two captive squirrel monkeys that were experimentally infected with ZIKV and two additional two uninfected squirrel monkeys. We compare the fecal findings to ZIKV testing in serum, saliva, and urine samples from the same individuals. Our findings show that fecal detection is a cost-effective, noninvasive method for monitoring wild populations of Neotropical primates as potential ZIKV reservoirs.
Source link: https://doi.org/10.1371/journal.pone.0209391
Methods The effects of ZIKV infection on mature neurons and microglia were determined at the molecular and cellular levels, in vitro using immunocompetent primary cultured neurons and microglia, as well as in vivo in adult immunocompetent mice following intracranial ZIKV inoculation. We have used C57BL/6 and the genetically diverse Collaborative Cross mouse strains, displaying a wide variety of exposure to ZIKV disease, to inquire about the correlation between ZIKV infection-induced neurons and microglia, and in vivo susceptibility to ZIKV. Following brain ZIKV infection, only neurons and not microglial cells were found in vivo and vitro, not microglial cells, triggering the question of the mechanisms responsible for microglia inflammation. Type-I interferons were not reported by neurons late after infection stimulated non-infected microglial cells in a primary cultured microglia.
Source link: https://doi.org/10.1186/s12974-022-02668-8
However, the role of ADE of ZIKV infection during pregnancy and in vertical ZIKV transmission is not well understood. We first determined which cell lines and primary cells could be used to study ZIKV ADE in vitro, and then compared the differences in the outcomes of infection experiments between these cells. We investigated the possibility that pregnancy may alter myeloid cells' ability to contract ADE by testing with ZIKV ADE assays with primary cells isolated from blood of pregnant women from different trimesters and among age-matched non-pregnant women. In comparison to non-pregnant women, there was no difference in permissiveness for ZIKV infection or the ADE risk of ZIKV infection in pregnant women's primary cells. Use of in vitro models of primary myeloid cells from pregnant women was found in conclusion that no increased acceptability for ZIKV disease and ADE of ZIKV infection was present in comparison to age-matched non-pregnant women.
Source link: https://doi.org/10.3390/v14122776
Infections with Flavivirus in pregnant women are not associated with vertical transmission, not related to vertical transmission. During the Zika virus epidemic in Brazil in 2015, acute cases of congenital infection were recorded in 2015. During the Zika virus epidemic in Brazil in 2015, however, significant cases of congenital infection were reported in 2015. The exact location of this new congenital disorder is still unclear, and more subtle infections in children born to mothers with ZIKV remain uncertain, and the full range of this common congenital disease is still unclear. This paper discusses the findings of a retrospective analysis of neurological and neurological examination in the first years of life of a cohort of 77 children born to pregnant women with ZIKV infection in Manaus, Brazil, from 2017 to 2020.
Source link: https://doi.org/10.3390/v14122659
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