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Abstract This paper explores the key causes of mosquito-borne Zika virus transmission by mosquito-borne transmission by mosquito-borne Zika virus by focusing on environmental, anthropogenic, and socioeconomic risks. In addition, socioeconomic variables such as poverty, socioeconomic status, and low-quality housing have an effect, as these are social causes that restrict access to certain facilities or infrastructure, which, in turn, promotes transmission when absent. This is the first review looking at the effects of anthropogenic factors on Zika transmission in Brazil, with a particular focus in Brazil.
Source link: https://doi.org/10.1007/s11356-021-15984-y
Infection with Zika virus, a member of the Flaviviridae family's Flavivirus genus, typically results in mild self-limited illness, but a select group of patients experiences severe neurological disease. The genetic similarity of ZIKV to other common flaviviruses, such as dengue virus, raises a barrier to the creation of specific ZIKV diagnostic assays. Nonstructural protein 1 has been developed for use in immunodiagnostic assays for flaviviruses. To solve the cross-reactivity of ZIKV NS1 with proteins from other flaviviruses, we used site-directed mutagenesis to create putative epitopes. All variant ZIKV NS1 polyclonal antibodies were affinity-purified to block antibodies bound to the closely related NS1 protein of DENV, a closely related NS1 protein. In the ZIKV antigen-capture ELISA, a NS1 protein from DENV, yellow fever virus, St. Louis encephalitis virus, and West Nile virus had significantly reduced reactivity.
Source link: https://doi.org/10.3390/v13091771
In vivo, the balance between virus neutralization and enhancement provided by the in vitro neutralization results was used to predict IVIG concentrations that could protect or enhance Zika, as well as dengue 2 disease in vivo. Our results reveal a new insight into how polyclonal antibodies interact with viruses, with ramifications for the use of polyclonal antibody therapeutics and the production and evaluation of the next generation flavivirus vaccines.
Source link: https://doi.org/10.3389/fimmu.2021.717425
According to statistics, a pregnant mother who has been diagnosed with ZIKV has been pregnant for ZIKV, her child will be affected by congenital disorders as well as Guillain-Barre syndrome. Could there be no correlation because of genetic changes in the virus, or not all Latin American is feeling the effects of microcephaly at the same time, with Brazil experiencing the virus's effects first, skewing the results, and making researchers underestimate the effects of microcephaly. Brazil has been reported to be hardest affected by a lack of research on recent microcephaly outbreaks, the addition of a pesticide to the water, and the Brazilian population being more vulnerable to microcephaly. Genetic mutations in the virus strain can be analyzed by the Brazilian population's original risk of genetic microcephaly.
Source link: https://doi.org/10.47611/jsrhs.v6i2.398
During the 2015-16 Zika virus epidemic, ZIKV-associated neurological disorders, Guillain-Barre syndrome, myelitis, meningoencephalitis, and deadly encephalitis were all reported in adults, including microcephaly, Guillain-Barre syndrome, meningoencephalitis, and fatal encephalitis. A RNA-seq analysis of the infected mouse brain revealed that genes involved in innate immune responses and cytokine-mediated signaling pathways were significantly upregulated six days after infection, which were also shown by RNA-seq analysis. In addition, ZIKV infection induced macrophage infiltration and activation, as well as an elevated IL-1–u03b2 expression, while microgliosis was not present in the brain. We established that ZIKV infection causes inflammatory cell death in human monocyte THP-1 cells and raises IL-1u03b2 secretion. An increase in C5a was also reported by complement activation in ZIKV-infected mice's brains. Our findings show that ZIKV infection in the brain in this animal model raises the IL-1u03b2 gene infiltrating macrophages and induces IL-1u03b2-mediated inflammation, which can contribute to neuroinflammation's detrimental effects.
Source link: https://doi.org/10.1101/2023.01.05.522967
Mobile phone records, most commonly in the form of Call Detail Records, is a valuable source of human movement data on unprecedented scale. When compared to other traditional data sources, we explore the potential benefits of using aggregated CDR-derived mobility to forecast the 2015-2016 Zika virus outbreak in Colombia. Both nationally and sub-nationally, we assess the effectiveness of our epidemic modeling strategy in capturing the ZIKV epidemic. This suggests that cell phone records provide a more accurate picture of human mobility habits. This work contributes to the ongoing debate on aggregated mobility estimates from CDRs reports, which can be used for social impact applications and humanitarian action with appropriate data security and privacy guarantees.
Source link: https://doi.org/10.1101/2021.08.09.21261630
Term: The Flaviviridae virus family includes Hepacivirus, Pestivirus, and Fla-vivirus, with approximately 70 viral species using arthropods as vectors. Many people infected with DENV are asymptomatic, and in some cases, lethal, according to clinical findings, but in other situations, it can be lethal. On the other hand, ZIKV has serious neurological signs in infants and adults. Since NS3 is highly conserved in all DENV serotypes and plays a vital role in viral replication, it makes it an excellent drug target. Computer-aided drug discovery has become increasingly important in drug discovery efforts in recent years, making the process quicker and more cost-effective, mostly ex-plained by finding new drugs against DENV and ZIKV.
Source link: https://doi.org/10.2174/1568026623666221122121330
In utero, Zika virus infects fetal neural progenitor cells, causing severe developmental abnormalities. Infected NPCs, the pathways are dysfunctional, but how ZIKV centrally reprograms these pathways is unclear. Here we show that ZIKV infections interferes with subcellular partitioning of host transcripts essential for neurodevelopment in NPCs, and we can relate this process to the up-frameshift protein 1. We show that a subset of mRNAs loses UPF1 binding in ZIKV-infected NPCs, consistent with UPF1u2019's reduced expression using infrared crosslinking immunoprecipitation and RNA sequencing, consistent with UPF1u2019's reduced expression.
Source link: https://doi.org/10.1371/journal.ppat.1011070
Abstract Zika virus is a rapidly spreading mosquito-borne flavivirus that can cause severe fetal abnormalities, including microcephaly. To produce anti-ZIKV-PSBs, we loaded polystyrene beads with a large number of ECL labels and conjugated them with anti-ZIKV monoclonal antibodies. These anti-ZIKV-PSBs effectively captured ZIKV in solution-building ZIKV-anti-ZIKV-PSB complexes, which were then subjected to measured ECL intensity after further magnetic beads separation. Our findings show that the anti-ZIKV-PSBs can capture as little as 1 PFU of ZIKV in 100 % of saline, human plasma, or human urine in 100 bcl.
Source link: https://doi.org/10.1038/srep32227
Abstract Insecticide resistance is a growing threat to mosquito control efforts around the world, so mosquito control efforts are on the quest for new target sites and insecticide-specific compounds are becoming more popular. mosquito inward rectifier potassium channels, according to emerging research, mosquito inward rectifier potassium channels are viable molecular targets for manufacturing insecticides with new methods of action. VU041, a submicromolar-affinity inhibitor of Anopheles gambiae and Aegypti Kir1 channels that incapacitates adult female mosquitoes from Anopheles gambiae and Aegypti Kir1 channels that incapacitate adult female mosquitoes from representative insecticide-susceptible and -resistant strains of Anopheles gambiae and Aegypti z ae b a submicromolar ae villian gy gypti Kir1 and Ae aes adult female mosquitoes from aquatic mosquitoes aes from Anophe gy gypti Kir1 and Aes adult female mosquitoes from Anophes aes from anthronaes from Anopho aes from Anophage-resistant Anopheles aes from Aes of Aes from Aes from A.
Source link: https://doi.org/10.1038/srep36954
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