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Zika Virus - BioProject

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Last Updated: 09 January 2023

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Transcriptomic reveals the ferroptosis features of host response in a mouse model of Zika virus infection

Zika virus is a neurotropic flavivirus with a neurotropic flavivirus. The outbreak of ZIKV in 2016 prompted a global health crisis, prompting the outbreak. Methods: We investigated the host response characteristics of in vivo replication in a mouse model of ZIKV infection in a mouse model of ZIKV infection by a series of transcriptomic and bioinformatic analyses of ZIKV and mock-infected brain tissue. ZIKV infected mice's brain tissue demonstrated tissue damage, inflammatory cells infiltration, and high viral replication were found in the ZIKV infected mice's brain tissue. We then identified 12 interacted hub ferroptosis regulators that were related to CD8+ T cells, microglia, and monocytes' differential expression. For the first time, we discussed a potential mechanism of ferroptosis in brain tissue infected with ZIKV in mice, as well as the four key ferroptosis regulators. Overall plan: Comparative gene expression profiling of RNA-seq data for zika virus-infected mice and control mice.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/882877


Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection

Zika virus and dengue virus are two members of the Flaviviridae family of RNA viruses that cause acute disease in humans. Both ZIKV and DENV contain over 90% of their genome sequences, but Zika and dengue infections' clinical characteristics are highly variable, with tropism and cellular effects. To determine the transcriptional and translational characteristics of ZIKV and DENV infection in human neuronal progenitor cells, we used simultaneous RNA sequencing and ribosome footprinting. The results also reveal the activation of various cell stress reponses, with ZIKV initiating a BACH1/2 redox program and DENV initiating the ETF/CHOP endoplasmatic reticulum stress program. In two biological replicates that were collected 72 hours post infection, we performed ribosome profiling and RNA sequencing of human neuronal progenitor cells either uninfected or infected with ZIKV or DENV.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/854905

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions