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Zika and dengue infections have inherited over 90% of their genome sequences, with exceptions relating to tropism and cellular functions. To determine the transcriptional and translational dynamics of ZIKV and DENV infection in human neuronal progenitor cells, we used simultaneous RNA sequencing and ribosome footprinting. According to the gene expression results, an increase in RNA translation capacity was shown by the discovery of aminoacyl tRNA synthetases and the translation-activating PIM1 kinase. Other cell stress reponses have been demonstrated by the results, with ZIKV launching a BACH1/2 redox scheme and DENV triggering the ETF/CHOP endoplasmic reticulum stress program. In two biological replicates that were obtained 72 hours post infection, we performed ribosome profiling and RNA sequencing of human neuronal progenitor cells that were either uninfected or infected with ZIKV or DENV.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/854905
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