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In the United States, West Nile virus is a leading cause of viral encephalitis. In ex vivo brain slice cultures, the PLX5622 was also used to investigate the role of intrinsic neuroinflammatory responses during WNV infection. Microglia were shown to reduce viral growth and cell death in WNV-infected BSCs, but not required for the cytokine/chemokine response to WNV infection. Microglia were found to play a role in neuroinvasive WNV infection defense in this study, as well as showing that microglia responses were independent of WNV-induced peripheral immune responses. Microglia have been shown to be helpful in WNV protection, but more research is needed to fully understand the effect these cells have on neuroinvasive WNV infections. Microglia were eliminated from an ex vivo brain slice culture model by PLX5622 to investigate the role of microglia in a WNV infection, according to this study.
Source link: https://doi.org/10.1128/spectrum.00685-22
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