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A complex microenvironment exists within adipose tissue, immune cells, and parenchymal cells that closely collaborate, creating a complex microenvironment. Diet-induced weight loss improves glucose tolerance, but weight gain compounds the loss of glucose homeostasis related to obesity. Imprinting of AT immune cells imprinting on weight loss and weight gain continued despite body loss and gradually worsened with weight gain, resulting in decreased type 2 regulatory cells, activation of antigen presenting cells, T cell exhaustion, and improved lipid handling in macrophages in weight cycled mice.
Source link: https://doi.org/10.1038/s41467-022-30646-4
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