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Weight Loss - MedlinePlus Genetics

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Last Updated: 24 November 2022

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Perry syndrome

The earliest signs of Perry syndrome are typically Parkinsonism and psychiatric changes. The most common psychiatric changes in people with Perry syndrome include depression, general loss of interest and excitement, isolation from family and relatives, and suicidal thoughts. Many affected individuals may also experience significant, unexplained weight loss early in the disease. People with Perry syndrome generally live for about five years after signs and symptoms first appeared.

Source link: https://medlineplus.gov/genetics/condition/perry-syndrome


Chronic myeloid leukemia

Normal bone marrow has red blood cells that contain oxygen, white blood cells that shield the body from infection, and platelets that are involved in blood clotting. The bone marrow secretly manufactures too many white blood cells in chronic myeloid leukemia. However, as the disease progresses, immature white blood cells called myeloblasts build in the blood and bone marrow. Myeloblast overgrowth impedes the growth of other blood cells, resulting in a shortage of red blood cells and platelets. Chronic myeloid leukemia most commonly occurs after age 60. When a blood test is done for another reason, approximately half of people with chronic myeloid leukemia do not have any signs and symptoms and are diagnosed. The number of mature white blood cells has risen in the chronic phase, and myeloblasts account for less than 5% of blood cells.

Source link: https://medlineplus.gov/genetics/condition/chronic-myeloid-leukemia


Systemic lupus erythematosus

Systemic lupus erythematosus is a persistent disorder that causes inflammation in connective tissues, such as cartilage and blood vessels' linings, which give strength and flexibility to structures throughout the body. SLE is one of a large group of disorders called autoimmune disorders that occur when the immune system attacks the body's own tissues and organs. Joint pain, often affecting both joints of the body, as well as muscle pain and weakness are common symptoms. Calcium deposits under the skin, contaminated blood vessels in the skin, and tiny red spots called petechiae are all common skin disorders that may result in SLE. In addition, affected individuals may have hair loss and open sores in the moist lining of the mouth, nose, or, less commonly, the genitals. About a third of people with SLE suffers from kidney disease. Heart problems can also occur in SLE, including inflammation of the sac-like membrane around the heart and abnormalities of the heart valves, which regulate blood flow in the heart. Heart disease caused by fatty buildup in the blood vessels, which is very common in the general population, is even more prevalent in people with SLE. processing, learning, and remembering information are all typical symptoms of SLE's inflammation, which can also damage the nervous system, resulting in abnormal sensations and weakness in the limbs; stroke; and difficulty processing, learning, and recalling data. People with SLE have episodes in which the illness is exacerbated and at other times when it gets better.

Source link: https://medlineplus.gov/genetics/condition/systemic-lupus-erythematosus


Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

CMC is a tendency to get skin, nails, and the moist lining of body cavities caused by a form of fungus called Candida. CMC is often the first of three APECED's three specific characteristics to become apparent in people with this disorder. Infections of the tube that moves food from the mouth to the stomach are also common, but the skin and nails are less common. Parathyroid hormone production is reduced as a result of damage to the parathyroid glands. In a third significant feature of APECED, adrenal gland insufficiency, damage to the small hormone-producing glands on top of each kidney's findings in a third major feature of APECED and adrenal gland insufficiency. Type 1 diabetes is a result of inadequate supply of insulin; a lack of growth hormone leading to short stature; and conditions affecting the internal reproductive organs that can cause inability to conceive children; and thyroid gland dysfunction can cause many signs such as weight gain and exhaustion. People with APECED can have a variety of additional signs and symptoms. Teeth enamel on the teeth and intermittent diarrhea or constipation may be among the early signs and symptoms that can be related to a lack of nutrients from food.

Source link: https://medlineplus.gov/genetics/condition/autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystrophy


Primary sclerosing cholangitis

Primary sclerosing cholangitis is a disease that affects the bile ducts. Primary sclerosing cholangitis occurs due to inflammation in the bile ducts, which results in scarring and narrowing of the ducts. Primary sclerosing cholangitis is usually diagnosed around age 40, and for unknown reasons, it affects both males and females twice as often as women. When people are diagnosed, no signs or symptoms of the disease are present, but routine blood tests reveal liver problems. Extreme exhaustion, pain in the abdomen, and severe itchiness are all typical early signs and symptoms of primary sclerosing cholangitis, as shown. Eventually, the accumulation of bile damages the liver cells, leading to chronic liver disease and liver disease. Vitamin D, a fat-soluble vitamin that helps calcium absorption and bones harden, and a lack of this vitamin can lead to bone thinning in people with primary sclerosing cholangitis. Primary sclerosing cholangitis is often associated with another condition, inflammatory bowel disease, which causes inflammation of the intestines and abdominal pain, is linked to inflammatory bowel disease. About 80% of people with primary sclerosing cholangitis have inflammatory bowel disease, the most common of the condition called ulcerative colitis. In addition, people with primary sclerosing cholangitis are more likely to have an autoimmune disorder such as type 1 diabetes, celiac disease, or thyroid disease than those without. People with primary sclerosing cholangitis are also at risk of getting cancer, particularly carcinoma of the bile ducts.

Source link: https://medlineplus.gov/genetics/condition/primary-sclerosing-cholangitis


Chronic granulomatous disease

Individuals with persistent granulomatous disease may have recurrent bacterial and fungal infections. People with this disorder may also have areas of inflammation in various tissues that can result in tissue damage. Chronic granulomatous disease is a common childhood disease that does not appear in childhood, although some people do not have symptoms until later in life. At least one significant bacterial or fungal infection outbreak in people with chronic granulomatous disease epidemics in the United States occur every 3 to 4 years. Individuals with chronic granulomatous disease may experience a form of fungal pneumonia called mulch pneumonitis, which causes fever and shortness of breath after exposure to decaying organic materials such as mulch, hay, or dead leaves. People with persistent granulomatous disease and the numerous fungi involved in their decomposition can develop fungal infections in their lungs. The skin, liver, and lymph nodes are among the common points of infection in people with persistent granulomatous disease. In patients with chronic granulomatous disease, inflammation can occur in several areas of the body. The stomach, colon, and rectum are all common areas of inflammation in people with chronic granulomatous disease, as well as the mouth, throat, and skin. Inflammation of the lymph nodes and bone marrow, which both produce immune cells, can lead to further impairment of the immune system. People with chronic granulomatous disease are also vulnerable to autoimmune disorders, which occur when the immune system malfunctions and attacks the body's own tissues and organs.

Source link: https://medlineplus.gov/genetics/condition/chronic-granulomatous-disease


21-hydroxylase deficiency

Deficiency of 21-hydroxylase deficiency is a genetic disorder that affects the adrenal glands. The adrenal glands produce excessive androgens, which are male sex hormones, in people with 21-hydroxylase deficiency. Males and females with either common or severe 21-hydroxylase deficiency tend to have an early growth spurt, but their final adult height is usually shorter than those in their family. In addition, affected individuals may have a reduced ability to have biological children. Females may also experience excessive body hair growth, male pattern baldness, and irregular menstruation. About 80% of people with classic 21-hydroxylase deficiency have the salt-wasting form. Individuals in the simple virilizing style do not experience salt loss. Females with the non-classic type of 21-hydroxylase deficiency have normal female genitalia. Males of the non-classic gender may have early beard growth and small testes. There are no signs of the disorder in people with this type of 21-hydroxylase deficiency.

Source link: https://medlineplus.gov/genetics/condition/21-hydroxylase-deficiency


Juvenile polyposis syndrome

Juvenile polyposis syndrome is a disorder that is characterized by a series of noncancerous growths called juvenile polyps. Polyps often appear before age 20; in the case of juvenile polyposis syndrome, the condition is a "juvenile" refers to the tissues that make up the polyp, not the age of the affected individual. About 16% of people with juvenile polyposis syndrome have other abnormalities, such as a twisting of the intestines, heart or brain abnormalities, an opening in the roof of the mouth, extra fingers or toes, or urinary tract abnormalities. Juvenile polyposis syndrome is diagnosed when a person has one of the following: more than five juvenile polyps in certain areas of the gastrointestinal tract; juvenile polyps in other parts of the gastrointestinal tract; or any number of juvenile polyps and one or two affected family members are affected. Single juvenile polyps are relatively common in children and are not indicative of juvenile polyposis syndrome. Based on the signs and symptoms of the disorder, three forms of juvenile polyposis syndrome have been identified. When polyps develop throughout the intestinal tract, polyposis of a different species, termed generalized juvenile polyposis, is identified. Polyps often occur during childhood among people with generalized juvenile polyposis and juvenile polyposis coli. People with juvenile polyposis syndrome have a ten to a five percent risk of gastrointestinal tract cancer. Colorectal cancer is the most common form of cancer found in people with juvenile polyposis syndrome.

Source link: https://medlineplus.gov/genetics/condition/juvenile-polyposis-syndrome


Ulcerative colitis

Ulcerative colitis is a chronic disease that affects the digestive system. The most common signs of ulcerative colitis are abdominal pain and cramping, as well as frequent diarrhea, often with blood, pus, or mucus in the stool. In some affected individuals, chronic bleeding from the inflamed and ulcerated intestinal tissue can lead to a red blood cell shortage. Ulcerative colitis has also raised the risk of colon cancer in people whose entire colon is inflammatory and in people with ulcerative colitis for 8 or more years. Ulcerative colitis is a common cause of inflammatory bowel disease. Unlike ulcerative colitis, which affects only the inner surface of the large intestine, Crohn disease can cause inflammation in any portion of the digestive tract, and the inflammation extends into the intestinal tissue.

Source link: https://medlineplus.gov/genetics/condition/ulcerative-colitis

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions