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The aim of this research was to determine if lifestyle-induced weight loss modulates gene expression in circulating monocytes. We reviewed and compared gene expression in monocytes and subcutaneous adipose tissue biopsies by unbiased mRNA profiling. In a prospective controlled clinical trial, samples were collected before and after diet-induced weight loss in well-defined males. Following weight loss, Four genes were differentially expressed in CD14+ cells. Comparative studies of paired CD14 + monocytes and subcutaneous adipose tissue samples before and after weight loss did not find common genes differentially expressed in both sample types.
Source link: https://doi.org/10.1038/s41598-020-74973-2
The extensive body of literature examines the role of social media applications in health-related problems. On the other hand, in booming countries like Pakistan, there is a lack of empirical evidence relating to social media app influence specifically on health issues. The purpose of the investigation sought to determine the purpose of social media applications, commonly used games, impact, and demographic characteristics on health-related topics. University students in Southern Punjab, Multan, Pakistan, were considered in three domains of health. The most common reason for using social media applications is to gather health-related information, quickly and conveniently, and YouTube is the most commonly used platform for this purpose. App designers and health professionals could help the masses adopt health-related habits and health-safety by supplying sufficient introductory app-related metrics, thus minimizing the risk perception of the masses.
Source link: https://doi.org/10.47067/ramss.v5i2.230
While using OnTrack, we have established preliminary feasibility, acceptability, and efficacy of OnTrack, but no research has looked at our hypothesized mechanism of action: reduced lapse frequency will lead to greater weight loss. This secondary analysis looked at the relationship between lapse frequency and the weekly percentage of weight loss. For ten weeks, participants with overweight/obesity used OnTrack, a digital weight loss program, for ten weeks. A nonsignificant relationship between weekly lapses and weight loss was found in Linear mixed models with a random effect of subject and a fixed effect of time. According to statistically significant moderation contribution of OnTrack involvement, such as the fact that less EMA and interventions were completed conferred the desired links between lapses and weight loss, according to Post hoc results. In this research, weight loss was not connected to weight loss, and one explanation may be the effect of engagement levels on this relationship.
Source link: https://doi.org/10.1093/tbm/ibaa097
Fusarium Head Blight is one of the most common worldwide wheat and other small grain diseases. The Fusarium pathogen survives the winter season well in plant debris left on the field. When an economically vital host plant is not present, weeds around and within crops are alternative hosts of Fusarium fungi. This paper discusses the identification of DNA of Fusarium species in chemically inoculated wheat plants with isolates from weeds as well as its effect on the severity of FHB and spring wheat 1000-grain weight under field conditions. The results revealed that the DNA concentration of F. graminearum was significantly higher in the grain than that of F. avenaceum. When wheat heads were inoculated with F. graminearum, the risk of FHB was significantly higher than with F. avenaceum. All F. graminearum strains reduced the weight of spring wheat grains by a significant amount, while F. avenaceum did not influence the weight of 1000 grain.
Source link: https://doi.org/10.3390/agronomy12112741
Objectives: Using repository data from 2931 participants in the Diabetes Prevention Program clinical trial in adults at high risk of type 2 diabetes, we investigated the effects of weight loss, an intensive lifestyle change, and metformin on the relationship between insulin secretion and sensitivity. During the active intervention period, insulin and glucose levels in fasting and 30-minute postload serum samples were estimated. Distances along and away from the regression line defined Insulin's clandestine request and compensatory insulin mystery, as well as compensatory insulin secrecy. ILS and metformin reduced covert insulin demand while also raising compensatory insulin production, with greater implications of ILS. Conclusion The amount of weight loss was directly related to the loss of body weight, which was primarily due to reduced insulin secretory demand coupled with increased compensatory insulin secretion.
Source link: https://doi.org/10.1210/clinem/dgac509
Obstructive sleep apnea is one of the most common chronic illnesses, and comorbid obesity accounts for more than half of cases. Both OSA severity and OSA-related signs are influenced by body mass, and OSA-related symptoms. We prospectively assessed the effects of a weight-loss program using the Berlin score to assess OSA risk, as well as the Epworth Sleepiness Scale to measure daytime sleepiness. DietSleep was a prospective multicentric cohort study looking at OSA risk and daytime sleepiness during and after weight loss surgery intervention. Since the intervention, Berlin scores increased from 36% to 7%. p. 0. 01; the percentage of patients with a Berlin score u22652 decreased from 3. 6 percent to 7%. The number of patients with ESS decreased from 13% to 2%, from 13% to 2%. These findings show that a weight-loss regimen results in clinically relevant weight loss and a significant increase in both OSA and subjective daytime sleepiness.
Source link: https://doi.org/10.3390/jcm11236890
ABSTRACT Background The introduction of dairy products in diet regimens has been shown to have mixed results on weight loss. According to a common belief, dairy aids weight loss by influencing endocrine processes involved with satiety and food intake controls. Objectives The purpose of the current study was to determine whether or not weight loss with or without adequate dietary dairy products could have a positive effect on subjective and objective appetitive measures. Methods A 12-wk randomised controlled feeding weight loss study showed that men and women who were habitual low dairy users. Before and during the experiment, 2 fasting blood draws and visual analog scale measurements were administered, followed by a standard breakfast, 5 postbreakfast blood draws and VASs, a standard lunch, and 12 postlunch blood draws and VASs were published and VASs. Weight loss per se has only had a modest effect on certain programs that monitor hunger and satiety.
Source link: https://doi.org/10.1093/jn/nxaa327
This review examined whether commercially available diet gels could have impeded the postoperative weight loss associated with major survival surgery in mice. C57BL/6 mice were divided into three groups that received moistened chow pellets alone or with one of two commercially available diet gels. Body weights of mice that received both moistened chow and diet gel on days 2 and 3 on one product were never different from baseline standards, which were nowhere different from baseline controls for the other product.
Source link: https://doi.org/10.30802/aalas-jaalas22-000030
Abstract Background Obesity is attributed to incident heart failure, but the underlying causes are uncertain. Methods We conducted a nested case-control analysis within the Swedish-Obese-Subjects study by identifying 411 people who exhibited HF and matched them with respect to age, sex, weight loss, and length of follow-up to 410 controls that did not develop HF. TNFRSF10A*, ST6GAL1, PRCP, MMP12, TIMP1, CCL3, QPCT, ANG, C1QTNF1, SERPINA5, and GAL-9 were all related to reduced HF risk, with some being related to reduced HF risk: LPL, but one was related to reduced HF risk: LPL. Patients with HF were more likely to experience weight loss syndrome and obesity in patients with diabetes, C1QTNF1, FGF-21, and CST3, showing dyslipidemia and kidney disease, had a greater correlation with HF in patients who did not experience weight loss or obesity. HF in obesity is a disorder that results in obesity, matrix reconstruction, cardiometabolic hormones, and hemostasis are among the HF predictors; three protein biomarkers predicting HF appeared to be obesity-specific.
Source link: https://doi.org/10.1038/s41366-022-01194-0
Interestingly, the poor results in the intestinal microbiota of patients with PD coincide with changes that are typical of people on a Western diet and are opposite to those that follow a Mediterranean diet. Dopamine bioavailability, role of influential food manufacturers in this research, how they influence the structure and function of the gut microbiota, and the subsequent effects on PD and obesity pathophysiology. We then discuss research into how microbiota transplantation and weight loss surgery can be used as therapeutic tools to restore dopaminergic deficits by optimizing gut microbial composition. Overall, knowing the role of diet in dopamine bioavailability and gut microbiota in dopamine-related diseases such as PD can help develop more specific therapeutic targets to cure dopaminergic deficiencies in neurologic and metabolic disorders.
Source link: https://doi.org/10.3390/ijms23147503
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