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There are 3 limitations in previous studies on the lifestyle behavior weight loss intervention. Young children's low-income overweight or obese mothers are particularly underrepresented. Prior lifestyle interventions in overweight or obese mothers have suffered from threats to internal stability, emotion, and cognition, among other things that are important for promoting and sustaining healthy lifestyle habits and health outcomes. This self-directed, web-based future thinking intervention will concentrate on increasing motivation and improving mood and cognition. The primary and secondary findings are intended to determine intervention fidelity and acceptability by the study participants', analyze potential intervention effects on the primary and secondary outcomes, investigate potential intervention effects on lifestyle habits, investigate potential effects of intervention strategies on motivation, emotion, and cognition, and evaluation of cost of various recruiting strategies.
Source link: https://clinicaltrials.gov/ct2/show/NCT04649047
Phase 3 of the study will be conducted entirely online, utilizing the VA's national TeleMOVE service and Virtual MOVE groups, and the study arms will now be TeleMOVE/Virtual MOVE + CBT. Several times a month, two VA CT sites host group orientation meetings at two VA CT sites, which take place multiple times per month. Through VHA3, the investigators will look for a sample that is 34% ethnic/ethnic minority to be similar to the demographics of a nationally representative sample of veterans receiving weight management services through VHA3. The investigators will also set out for 25% women, a figure that shows an oversampling of women relative to the overall VHA's average of 6%. The VHA's weight control services are provided in a variety of ways, with the group structure accounting for 75% of all weight control services provided across the region. A greater number of patients are seen for weight control at the Newington campus compared to the West Haven campus, according to the West Haven campus. Dr. Driscoll, a women's health researcher for the VHA's Women's Practice Based Research Network and clinical supervisor for the local women's clinic, will be charged with recruiting women Veterans into the MOVE. "Recurrent binge eating" on screen will determine the presence of binge eating by the MOVE. "On average, how often have you consumed large amounts of food at one time and felt that your eating habits had been out of control at that time. " Developing your knowledge with the Eating Disorder Examination-Interview 12th Ed. Before IRB written informed consent is obtained, the Research Assistant will discuss the findings, and the consent will be discussed verbally and in writing. The following will be obtained/completed during the pre-treatment assessment session: anthropometric findings, demographic data, self-report results, blood draw, and psychiatric evaluation with the Eating Disorder Examination-Interview 12th Ed. Clinical BED Examination vs. Clinical BED The Eating Disorder Examination-Interviewer is the most comprehensive diagnostic questionnaire that is widely used to diagnose and assess the signs of binge eating disorders, including binge eating and eating disorder pathology. Procedures for randomization MOVE is randomly selected from a list of eligible patients who promise to participate and sign consent forms. Given the potential for disseminability, a VA CT group is the most widely used weight management service, and was therefore chosen as the treatment-as-usual for the present study. One of the efforts to broaden the reach and impact of weight management in the veteran population has been to find vulnerable subgroups of overweight/obese patients such as those with binge eating8, pain56, and persistent mental disorders57. MOVE!+gshCBT A-half of participants will be randomly assigned to MOVE!+gshCBT and will be sent the MOVE!+gshCBT and will be awarded the MOVE! The gshCBT therapy will follow a manual written by Dr. Masheb and generally follows the book Overcoming Binge Eating 58, which has been used by Drs. If participants would like to use these food diaries for their MOVE, they can use these food diaries. Participants who attend a session with incomplete food diaries or self-monitoring will be able to complete these records for at least the first day or two days. Recording of these observations will be required and participants who arrive to session with incomplete food diaries or self-monitoring will be asked to use session time to complete these reports for at least the previous day or two. The investigators will continue this tactic throughout all CBT sessions until the patients arrive to sessions with diaries that have been completed. Patients will also be encouraged to gradually increase moderate physical fitness with the aim of establishing 30 minutes of activity walking sessions or other activities five times per week. Measurements Participant assessments will be carried out by the Research Assistant and independent of the treating Psychologist, so that the assessment will be objective. If model assumptions are not fulfilled, changes of model type as well as updating the results will be considered. Logistic regression models will be used for categorical purposes such as binge remission and achieving clinically meaningful weight loss, i. e. , 5% weight loss or more. Aim 1 addresses binge eating primary result and mental health outcomes. Mixed effects models will be used to determine a decrease in the frequency of binge eating over time. Mental health outcomes H2, validated symptom scales for depression and quality-of-life will also be assessed using mixed models. The number of MOVEs stands out for Aim 2 in terms of participation in weight loss therapy, i. e. , the number of MOVES! During the intervention and follow-up phases, the intervention and follow-up phases will determine the effect of weight loss using a mixed effects model, as described above, using longitudinal changes in percent weight loss during the experiment and follow-up phases. Using logistic regression statistics, logistic regression analysis will also be conducted. Aim 3 is an investigation into predictors, moderators, and indicators of treatment results. Predictors are variables present at baseline that influence outcome regardless of therapy type, and moderators are variables present at baseline that influence outcomes based on the treatment condition. Potential predictors and moderators H1 will be investigated with demographic age and gender81, as well as clinical features and comorbidity from the relevant literature on BED82,83. With correlation analyses, associations H2 between weight control policies and physical fitness have changed, as well as physical fitness training, and weight loss 71 will be investigated.
Source link: https://clinicaltrials.gov/ct2/show/NCT03234881
All participants in this study will be offered a 4-month Internet-based weight loss program as part of a 8-month Internet-based weight loss service. Following the 4-month weight loss program, participants will be offered an 8-month weight loss service. On the study website for one week per month, participants will be invited to view monthly video lessons focusing on WL survival tactics, prevention of WL retention, and physical activity minutes. Those selected for 'brief' phone coaching will be required to complete three phone calls with a mentor between weeks 5-8 of the study, and those chosen for 'extended' phone coaching will be required to complete 12 phone calls with a coach between weeks 5-16. Following completion of all coaching calls participants, there will be no further interaction with the coach, but the coach will remain enrolled in the Internet service.
Source link: https://clinicaltrials.gov/ct2/show/NCT03867981
Individuals with PAD, who are also obese, are able to claudicate 40% more quickly than non-obese individuals, and recovery takes 20% longer after claudication. Older obese adults without PAD have shown that a combination of exercise and weight loss are more effective at improving physical stability and body composition than exercise alone. This study will determine whether weight loss and exercise versus exercise alone will 1 increase mobility function walking ability to a greater degree than exercise alone, and 2 identify the mechanisms that underlies mobility function changes by measuring muscle microvascular perfusion and composition. In obese Veterans with PAD, the investigators predict that a combination of weight loss and aerobic exercise aerobic and restive will result in more mobility improvements and reduced muscle perfusion and reduced muscle fat infiltration.
Source link: https://clinicaltrials.gov/ct2/show/NCT02607033
Increasing the amount of bypassed intestine during gastric bypass surgery improves outcomes and impacts molecular and metabolic changes that may have an effect on gastric bypass surgery, according to the main aim of the study. The proposed research will examine not only the role of intestinal bypass in effective weight loss therapy, but also the role of intestinal bypass in effective weight loss therapy. Regardless of whether weight loss results are similar in patients with differing lengths of bypassed intestine, the role of the gut in gastric bypass will be investigated by analysis of gut microbiota, circulating miRNAs, and gut hormones, three mechanisms that have been suspected of contributing to the success of the gastric bypass for weight loss surgery. The investigators will track gut hormone levels after small amounts of intestinal bypass to determine the role of intestinal bypass in the development of gut hormone production that influences metabolism, appetite, and possibly weight loss. The results of surgical weight loss on gut microbiome will be used by Sleeve gastrectomy patients to determine the role of bypassed intestine in changes in intestinal microbiome after weight loss surgery will be investigated. When the gut microbiota are modified after weight loss surgery, the investigators will be able to determine any correlation with weight loss and metabolic disease by comparing clinical findings. The following three groups will be included: Alimentary limb length 100 cm and biliopancreatic limb length of 150 cm. During randomization to the three gastric bypass groups, the following three groups will be used: Alimentary limb length 100 cm and biliopancreatic limb length of 100 cm In each group, there will be 15 participants in this pilot study for each of the gut hormone assays, gut microbiome analysis, and miRNA arrays. The blood will be collected by MU Health Care laboratories or other research workers and then couriered by courier according to the OneHealth Biorepository or another research lab. At 1 week, 1 month, 3 months, 6 months, and 12 month follow-up visits, the first week, 1 month, 3 months, 6 months, and 12 month follow-up appointments will show that weight loss surgery will include high weight when entering the weight loss surgery program, immediate preoperative weight measurement, and postoperative weight measurements will include high weight when starting the weight loss surgery program, immediate preoperative weight measurements on the day of surgery and postoperative weights. Diabetes mellitus with glycated hemoglobin levels measured preoperatively and 6 and 12 months postoperatively would be considered by a diabetic whose HgbA1C is above average. If preoperative abnormalities of LDL and HDL cholesterol and triglycerides return to normal in the absence of lipid-lowering agents, a remission of dyslipidemia will be considered. Aim 3: miRNA profiling in patients undergoing gastric bypass with variable intestinal bypass lengths will be investigated in each group for a total of 75 patients. Plasma will be used to analyze expression of all commonly used miRNAs by Affymetrix miRNA arrays. MiRNA expression in treatment groups will be compared. MiRNA expression levels will also be measured in terms of clinical outcomes. Aim 4: Measure change in gut microbiome as a result of increased intestinal bypass during gastric bypass. A total of 75 patients will be examined.
Source link: https://clinicaltrials.gov/ct2/show/NCT04841057
This randomized trial will determine the risk and cost-effectiveness of novel modules administered prior to weight loss that are specifically designed to encourage healthy lifestyle habits without regard to long-term health problems, and consequently increase the number of individuals experiencing 7% weight loss over the long term. We'll use Fun First to see whether it's more beneficial than Weight Watchers using a mediator-intervention interaction scheme with enough statistical support for the interaction effect as well as the intervention and mediator main effects for Aim 1. For Aim 2, we'll see if Fun First is more cost-effective than Weight Watchers, population-level epidemiology and cardiovascular disease prevalence, health care and disability expenditures, and quality-adjusted life years throughout the life course.
Source link: https://clinicaltrials.gov/ct2/show/NCT03014414
Determine the impact of an addiction-based weight loss program, embodied as a smartphone app with telephone support, on the weight loss of overweight and obese adolescents and young adults in need of stem cell transplantation. OUTLINE: Patients are sent an iPhone with the W8Loss2Go app, a body scale, and a digital food scale to weigh themselves and food daily. Patients also have telemedicine interviews with the coach lasting 60 minutes to raise both positive and negative effects on weight management and to identify challenges such as emotional eating, relocation habits, poor coping skills, and life stressors. Patients who want to prolong the intervention until month 12 attend an additional telemedicine consultation with the coach.
Source link: https://clinicaltrials.gov/ct2/show/NCT04453072
As a result of the country's largest agricultural disaster, millions of people living in Michigan were exposed to brominated flame retardants. PBB is stored in body fat, and community members have asked if weight loss can reduce body burdens of PBB and other lipophilic chemicals. The researchers believe that orlistat may reduce the body burden of PBB and other POPs since PBB is stored in body fat. This research is a prospective, placebo-controlled trial of orlistat plus diet and exercise for six months in a population with elevated PBB levels.
Source link: https://clinicaltrials.gov/ct2/show/NCT03582722
Participants Total number of survey participants has increased to 75-90, including overweight men and women of 18-45 years of age, with overweight men and women from 18-45 years old. LB001: Dietary supplement consisting of probiotic capsules is a form of dietary supplement that contains dietetics. The placebo is made from rice flour. Any study participants, regardless of randomization, will get general advice on healthy lifestyle habits because one of the inclusion criteria is "willingness to shed weight. ".
Source link: https://clinicaltrials.gov/ct2/show/NCT04897698
African Americans have a higher risk of these risk factors, as well as the highest risk of CRC and related mortality. Multiple risk factors are now linked to elevated circulating and fecal bile acids as well as a change in BA amino acid conjugation from glycine to taurine, which are also connected to elevated circulating and fecal bile acids. The presence of H2S-producing bacteria in the colon of AAs is significantly higher than that of non-Hispanic whites, and is a distinguishing feature among AA CRC trials that point to the development of CRC in a race-dependent manner. Particularly among AAs, the investigators hypothesize that attacking the BA-gut microbiome axis to reduce the availability, growth, and metabolic activity of H2S and DCA producing bacteria through diet and weight loss could minimize CRC risk, particularly among AAs. No studies have investigated the effects of a MedDiet alone, WL through lifestyle change, or a calories restricted MedDiet for WL on the BA-gut microbiome axis and its relevance to CRC prevention among AAs. 2 Concentration and composition of circulating and fecal BAs; 2 Gut microbiota and metabolic function; and 3 Gene expression profiles of exfoliated intestinal epithelial cells. The investigators will use samples and data obtained at baseline, mid-study, and post-intervention to determine the effects of the experiments on 1 Concentration and composition of circulating and fecal BAs; 2 Gut microbiota and metabolic function; and 3 Gene expression profiles of exfoliated intestinal epithelial cells This research, if successful, may have a major public health impact on CRC risk among AAs and other high-risk populations, which may lead to timely dissemination opportunities.
Source link: https://clinicaltrials.gov/ct2/show/NCT04753359
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