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Vitamin K - Springer Nature

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Last Updated: 09 August 2022

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A systematic review and meta-analysis of non-vitamin K antagonist oral anticoagulants vs vitamin K antagonists after transcatheter aortic valve replacement in patients with atrial fibrillation

Patients with aortic valvular disease are increasingly receiving transcatheter aortic valve replacement. Despite this, there is still a paucity of study and established guidelines on anticoagulation use in patients with AF. Vitamin K antagonists were included in seven studies, with 9764 patients on non-vitamin K antagonist oral anticoagulants and 15,435 patients on vitamin K antagonists including AF. No discernable differences between patients on NOAC and VKA for all-cause mortality at 2 years, stroke within 30 days, stroke within 1 year, ischaemic stroke at 1 year, and life-threatening bleeding at 30 days were found between patients on NOAC and VKA for all-cause mortality at 2 years, stroke within 30 days, ischaemic stroke within 1 year, and life-threatening bleeding at 30 days. NOAC's findings, according to the authors, are a potential alternative therapy modality to VKA in post-TAVR patients with AF, but further research is required to establish the complete safety and effectiveness profile of NOAC.

Source link: https://doi.org/10.1007/s00228-022-03371-6


A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Vitamin K's anti-ferroptotic function and show ferroptosis suppressor protein 1 as the enzyme mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle, according to biochemical and lipidomic studies. Although substantial progress has been made in determining cell sensitivity toward ferroptosis have been elusive, additional cell-extrinsic and cell-intrinsic steps that determine cell sensitivity toward ferroptosis remain unclear. Ferroptosis suppressor protein 1, a NADH-ubiquinone reductase and the second mainstay of ferroptosis control, was discovered to reduce vitamin K to its hydroquinone, a potent radical-trapping antioxidant and a preventer of lipid peroxidation. Vitamin K deficiency, FSP1-mediated vitamin K depletion was also responsible for the antidotal action of vitamin K against warfarin poisoning. It follows that FSP1 is the enzyme mediating vitamin K reduction in the canonical vitamin K cycle's reduction in the canonical vitamin K cycle's 6.

Source link: https://doi.org/10.1038/s41586-022-05022-3


Midwives’ Perspectives about Vitamin K Prophylaxis Against Vitamin K Deficiency Bleeding of the Newborn

Background The American Academy of Pediatrics has developed a single intramuscular vitamin K injection at birth to minimize Vitamin K deficiency Bleeding of the Newborn. Investigators have found an increasing incidence of IM vitamin K refusal among parents who choose midwife-assisted deliveries, despite the fact that no one else has affected IM vitamin K refusal. Methods We investigated midwives' perspectives on IM vitamin K prophylaxis and helping parents using qualitative methods in Connecticut, Iowa, and Michigan. To understand midwives' perspectives on IM vitamin K prophylaxis and holistic therapy, we conducted in-depth semi-structured interviews of midwives affiliated with three tertiary academic medical centers and nearby communities in Connecticut, Iowa, and Michigan. We interviewed 19 white female midwives from various career paths. Participants in Certified Nurse Midwives routinely recommended IM vitamin K prophylaxis and Certified Professional Midwives took a more neutral route.

Source link: https://doi.org/10.1007/s10995-022-03423-4


The effect of Vitamin-K_1 and Colchicine on Vascular Calcification Activity in subjects with Diabetes Mellitus (ViKCoVaC): A double-blind 2x2 factorial randomized controlled trial

Methods 154 patients with diabetes mellitus and coronary calcification, as determined by computed tomography, were randomized to one of four treatment groups in a double-blind, placebo-controlled 2x2 factorial trial of three months duration. The change in coronary maximum tissue-to-background ratio on 18F-NaF PET was estimated as a decline in coronary maximum tissue-to-background ratio. Conclusions In patients with type 2 diabetes, neither vitamin-K_1 nor colchicine significantly reduces coronary calcification activity, as estimated by 18F-NaF PET over a period of 3 months.

Source link: https://doi.org/10.1007/s12350-021-02589-8


Non-Vitamin K Antagonist Oral Anticoagulants (NOACs) Versus Warfarin in Patients with Atrial Fibrillation and (Morbid) Obesity or Low Body Weight: a Systematic Review and Meta-Analysis

Guidelines recommend using non-vitamin K antagonist oral anticoagulants over vitamin K antagonists in the general AF population, with goalizing systemic thromboembolism in atrial fibrillation. Hence, a critical analysis of the benefit-risk profile of NOACs in AF patients across the body weight spectrum is required. NOAC use in obese and class III obese AF patients was significantly reduced stroke/systemic embolism risks, compared to VKAs, with reduced major bleeding risks and similar mortality risks.

Source link: https://doi.org/10.1007/s10557-020-07122-6


Neglected vitamin K deficiency causing coagulation dysfunction in an older patient with pneumonia: a case report

Background The emergence of coagulation disorders in older people can be risky and fatal, especially those with multiple medical conditions. When anticoagulant drugs are not used and the patient shows no signs of bleeding, Vitamin K-dependent coagulation disorders are quickly dismissed. Case Presentation We present a case where a 71-year-old male suffering from a severe coagulation disorder without bleeding signs. A decrease in prothrombin times was observed in subsequent mixing experiments with normal plasma. Conclusions: Overall, timely vitamin K supplementation with microbiotics that influence vitamin K metabolism is important, especially in older patients who are multimorbid, frail, or nutritionally impaired, and those who are admitted to hospital because of an infection that necessitates antimicrobial therapy are at risk of clotting disorders due to altered gut flora.

Source link: https://doi.org/10.1186/s12877-022-03327-6

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions