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Vitamin K - Europe PMC

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Last Updated: 09 August 2022

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Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis.

Background High-quality evidence for oral anticoagulants in patients with cerebral venous thrombosis is lacking. Patients with cerebral venous thrombosis undergone systematic review and meta-analysis to determine the effectiveness and safety of DOACs versus vitamin K antagonists in patients with cerebral venous thrombosis. A series of keyword and control vocabulary terms for cerebral venous thrombosis, vitamin K antagonists/warfarin, and DOACs were among the search keywords for cerebral venous thrombosis, vitamin K antagonists/warfarin, and DOACs. We reviewed both randomized and nonrandomized studies that compared vitamin K antagonists and DOACs in 5 or more patients with cerebral venous thrombosis. DOAC had similar dangers of recurrent venous thromboembolism, major hemorrhage, intracranial hemorrhage, death, and complete venous recanalization when compared to vitamin K antagonist therapy. Conclusions and conclusions show that in patients with cerebral venous thrombosis, DOACs, and warfarin may have similar effectiveness and safety.

Source link: https://europepmc.org/article/MED/35938419


Efficacy and Safety of the Non-Vitamin K Antagonist Oral Anticoagulant Among patients with nonvalvular atrial fibrillation and Cancer: A Systematic Review and Network Meta-analysis.

Affective fibrillation in patients with cancer is at a higher risk of atrial fibrillation. There are currently no published studies on the effects of nonvitamin K antagonist oral anticoagulant and warfarin in cancer patients with AF. There were studies that compared NOACs to warfarin in the context of AF and cancer. In patients with AF and cancer with NOACs, there was a reduced risk of major bleeding and combined ischemic stroke/SE in patients with AF and cancer relative to warfarin. In addition, there was a reduced incidence of Intracranial and major gastrointestinal bleeding in patients who received NOACs compared to warfarin. According to Network reports, apixaban and dabigatran were associated with decreased major bleeding reduction in comparison to warfarin. NOACs had a reduced risk of major bleeding ischemic stroke/SE among patients with AF and cancer than warfarin. In addition, NOACs were attributed to reduced intestinal and intracranial bleeding.

Source link: https://europepmc.org/article/MED/35932849


A non-canonical vitamin K cycle is a potent ferroptosis suppressor.

Although significant progress has been made in understanding the molecular functions responsible for ferroptosis, additional cell-extrinsic and cell-intrinsic steps that determine cell sensitivity toward ferroptosis are also unknown. Vitamin K deficiency was also responsible for the antidotal effect of vitamin K against warfarin poisoning, thanks to the FSP1-mediated reduction. It follows that FSP1 is the enzyme mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle 6.

Source link: https://europepmc.org/article/MED/35922516


Neglected vitamin K deficiency causing coagulation dysfunction in an older patient with pneumonia: a case report.

Background The onset of coagulation disorders in senior citizens can be lethal and lethal, particularly those with multiple medical conditions. When anticoagulant drugs are not used and the patient shows no signs of bleeding, Vitamin K-dependent coagulation disorders are quickly dismissed. Case presentation We present a case of a 71-year-old male suffering from a pulmonary infection with severe coagulation disease with no bleeding signs. At the time of admission, Coagulation results were normal, prothrombin time is 13. 9 seconds, and activated partial thromboplastin time is 30. 2 seconds. Conclusions Overall, effective vitamin K supplementation with antimicrobials that influence vitamin K metabolism, particularly in older patients who are multimorbid, frail, or nutritionally impaired, and those admitted to hospital due to an infection that requires antimicrobial therapy are at risk of clotting disorder due to improper gut flora.

Source link: https://europepmc.org/article/MED/35907829


Systematic review of efficacy of direct oral anticoagulants and vitamin K antagonists in left ventricular thrombus.

Aims Left ventricular thrombus raises the risk of thrombotic events and mortality. As a result of which direct oral anticoagulant use has recently increased, vitamin K antagonists used to treat LVT have several known risks. Patients on DOACs in North American and European regions, as well as those with ischaemic heart disease, had a significantly lower risk of bleeding events than those living in other regions or areas with a different LVT aetiology, respectively. Patients on DOACs were significantly reduced in stroke in patients on VKAs compared to VKAs, and patients on DOACs in North America and those with IHD were at a significant risk of stroke. Conclusions compared to VKAs and CDACs greatly reduced the risk of bleeding events and stroke in LVT patients, but mortality rates remained stable in both groups.

Source link: https://europepmc.org/article/MED/35894752


Vitamin K content of cheese, yoghurt and meat products in Australia.

Vitamin K content of Australian foods are limited, limiting the estimation of vitamin K intakes in the Australian population. MK-5 was used to make Cheddar cheese and cream cheese. MK-8 was discovered only in Cheddar cheese. Australia needs a vitamin K food composition survey that is representative of Australian foods as the K vitamer profile and concentrations seem to vary widely by geographic location.

Source link: https://europepmc.org/article/MED/35907393


Direct oral anticoagulants or vitamin K antagonists after TAVR: A systematic review and meta-analysis.

Several patients undergoing transcatheter aortic valve replacement may also need oral anticoagulation for atrial fibrillation or deep vein thromboembolism, according to the author. Compared to VKA, DOACs use after TAVR was associated with a modest but significantly lower risk of all-cause mortality, with results mainly borne by observational studies. Conclusion Compared to VKA's fullness of available evidence, in patients undergoing TAVR with a concomitant warning of OAC, the DOACs-based plan is an effective and safe anticoagulation tool.

Source link: https://europepmc.org/article/MED/35901908


Optimal quality of vitamin K antagonist therapy in Japanese patients with venous thromboembolism.

COMMAND VTE Registry is a multicenter registry in Japan that enrolls consecutive 3027 patients with acute symptomatic VTE in 29 centers. TTR's rate in the U226570-70 percent range, based on the PT-INR range of u22651. 5 and 2. 0 showed the lowest cumulative incidence rate. In the optimal quality group, the cumulative 1-year incidence and the adjusted risk for the primary outcome measure were significantly smaller than in the non-optimal quality group. Regardless of the etiology of VTE, the optimal quality group's relative to a non-optimal quality group's clinical results remained stable. Conclusions The most effective intensity of VKA therapy, according to the current Japanese guideline model, was between u22651. 5 and 2. 0, which could have been consistent with improved results, and the high quality of surveillance for TTR therapy of TTR u226570 percent was independently related to improved outcomes.

Source link: https://europepmc.org/article/MED/35882615


Vitamin K intake and risk of lung cancer: the Japan Collaborative Cohort Study.

Numerous in vitro and in vivo studies have reported that limited research from human prospective studies showed vitamin K's possible role in lung cancer formation, but vitamin K's anticarcinogenic properties were confirmed from multiple in vitro and in vivo studies. Purposes We investigated the relationships between total vitamin K intake from food and lung cancer formation in this large prospective cohort study. Methods of Evaluation Vitamin K intake in 42,166 people at the Japan Collaborative Cohort Study's baseline were determined by a validated food frequency questionnaire. Using the Cox proportional hazard regression method based on vitamin K intake quartiles, Hazard ratios and 95% confidence intervals of incident lung cancer were calculated. Vitamin K intake was shown to be inversely correlated to lung cancer risk, according to the multivariable HR for the top vs. lowest quartiles, which was 0. 67. Conclusion: Vitamin K supplements can reduce the risk of lung cancer.

Source link: https://europepmc.org/article/MED/35871570


Comparing the efficacy and safety of direct oral anticoagulants versus Vitamin K antagonists in patients with antiphospholipid syndrome: a systematic review and meta-analysis.

In the secondary prevention of thrombosis in APS patients, results comparing direct oral anticoagulants to Vitamin K antagonists are contradictory. DOACs' efficacy and safety are evaluated and analyzed literature on the effectiveness and safety of DOACs compared to VKAs in treating patients with APS. Compared to others using VKAs, high-risk APS patients who used DOACs had an elevated risk of recurrent thrombosis [risk ratio = 3. 65, 95% confidence interval : 29-8. 93; I2 = 29 percent, P = 0. 005]; compared to those using VKAs. Upon administering DOACs or VKAs in low-risk APS patients, a similar risk of recurrent thrombosis or major bleeding was reported in low-risk APS patients. In the absence of contraindications, this meta-analysis shows that VKAs remain the first-choice treatment for high-risk APS patients, with DOACs being the more appropriate option for low-risk APS patients. Different DOACs may have different efficacy and safety for thromboprophylaxis in APS patients and require further investigation.

Source link: https://europepmc.org/article/MED/35867933

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions