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Vitamin E is not accessible to 96% of American women, without apparent harm. Because vitamin E is an antioxidant, optimal intake of vitamin E can support obesity-prone women with elevated levels of inflammation and oxidative stress, which may also contribute to heightened inflammation and oxidative stress. We hypothesize that vitamin E serves as an antioxidant in its tissue stores, and that delivery to tissue stores can be determined from plasma vitamin E turnover kinetics from slow release pools. As a new way to determine vitamin E recommended dietary intake, we suggest turnover kinetics. Because the fat-content of a meal can influence vitamin E absorption, fat content of a meal will influence vitamin E absorption in a preliminary trial 1. The fat content in preliminary trial 1 would be 0 - 40% of calories in the breakfast meal during which vitamin E will be administered. In a preliminary trial 2, the most effective fat content from preliminary trial 1 will be used, and the vitamin E dose will be adjusted. Vitamin E doses may indefinitely influence vitamin E kinetics. In addition, we'll monitor vitamin E intakes for women as a result of lipid peroxidation biomarkers to produce real data that can be used to forecast vitamin E intakes for women and make new vitamin E recommendations. To investigate the relationship between vitamin C status and vitamin E turnover, we'll use a vitamin C depletion-repletion study approach because vitamin E turnover can be affected by vitamin C depletion increases.
Source link: https://clinicaltrials.gov/ct2/show/NCT00862433
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