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Vitamin D - Wiley Online Library

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Last Updated: 22 June 2022

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Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study

We wanted to investigate the prospective association of vitamin B5 with all-u2010cause mortality and potential modifiers in Chinese adults with hypertension. In the China Stroke Primary Prevention Trial, a nested, case-u2010control study was conducted, including 555 deaths of all causes and 505 matched controls. The mean plasma vitamin B5 concentration in cases was higher than in controls. The chance of all-u2010cause mortality rose by 29 percent in Q2, 22% in Q4, 62% in Q4, and 77% in Q5, when vitamin B5 was further analyzed as quintiles relative to the reference group. When Q4u2010Q3 were added, a significant 41% increase in all-u2010cause death risk was found compared to Q1u2010Q3. According to this report, elevated baseline values of plasma vitamin B5 may be a risk factor for all-u2010cause mortality among Chinese patients with hypertension, particularly among older adults and those with adequate folate levels.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jch.14516


Performance status modifies the association between vitamin D receptor activator and mortality or fracture: A prospective cohort study on JSDT Renal Data Registry

Vitamin D receptor activators may have adverse effects in immobilized patients. The aim of this research was to clarify the effect of performance status on VDRA use and outcomes in hemodialysis patients. Among those with poor PS, the correlation between higher Ca levels and VDRA use was even greater. Among VDRA users, the adjusted HR for mortality and incidence rate ratio for hip fracture was 1. 02 and 0. 93. Among subjects with higher mortality and incidence of hip fractures among subjects with high PS but not among those with poor PS. In summary, VDRA use was associated with improved outcomes only among those with high PS. These findings show that hemodialysis patients' bone and mineral imbalances can be handled differently, depending on their health status.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbmr.4621


Safety of vitamin D2 mushroom powder as a Novel food pursuant to Regulation (EU) 2015/2283 (NF 2019/1471)

Following an invitation from the European Commission, the EFSA Panel on Nutrition, Novel Foods, and Food Allergens was requested to provide an opinion on vitamin D2 mushroom powder as a novel food under Regulation 2015/2283. Vitamin D2 in the NF is present in the form of vitamin D2 in the range of 125 to 375 mg/g. Given the fact that the number of foods fortified with vitamin D has increased over the years, as well as the marketing of high-u2010dose vitamin D supplements, the Panel acknowledges confusion regarding total exposures to vitamin D for the general population.

Source link: https://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2022.7326


B‐vitamin supply in plants and humans: the importance of vitamer homeostasis

However, it should be noted that each individual B vitamin is a family of compounds whose control includes designated pathways. B1, B6 and B9's specific functions and importance to metabolism in both human and plant health, and we'll explore the benefits of vitamer homeostasis here. Not only the total number of vitamins but also the often-glected homeostasis of each B vitamin's various vitamers is vital to human and plant health, according to research on B vitamin metabolism over the past several years, but also the often-u2010neglected homeostasis of the various vitamers of each B vitamin is important to human and plant health. These B vitamins are crucial micronutrients and we briefly discuss the possibility of plant biology studies in favor of human health.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/tpj.15859


Gastroprotective effect of vitamin U in D‐galactosamine‐induced hepatotoxicity

Vitamin U has been shown to be a potent antioxidant in several toxicology experiments. The current research was designed to investigate Vit U's anti-GalNu2010-induced stomach injury. Rats were divided into four groups as follows: control, Vit U given animals, GalN administered animals, GalN administered animals, GalN + Vit U given animals, and GalN + Vit U given animals. Vit U has been shown to have its unique antioxidant function, as well as prevents GalN-u2010-induced gastric damage.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbt.23124


Siderophores of Bacillus pumilus promote 2‐keto‐L‐gulonic acid production in a vitamin C microbial fermentation system

Vitamin C's precursor, u2010kulonic acid, is biou2010converted from l'u2010sorbose by a microbial group of Ketogulonicigenium vulgare and a helper strain. Bacillus pumilus SYu2010A9's siderophores were purified and added to a monoculture fermentation system in K. vulgare 25 billion Billion1 in order to determine the effects of siderophores on improving 2u2010KLG yield, which were boosted by 220KLG yield. When the added concentration of siderophores was 500 g/L, the titer of 2u2010KLG reached 7. 18 g/L within 60 h and increased by 75%. u00b5g/L were 450 mg/L.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jobm.202200237


UK Nutrition Research Partnership ‘Hot Topic’ workshop: Vitamin D—A multi‐disciplinary approach to (1) elucidate its role in human health and (2) develop strategies to improve vitamin D status in the UK population

Low vitamin D status has been documented in a variety of population groups around the world, including communities in low latitude areas despite the abundance of sunlight. Vitamin D status is shown by the level of circulating metabolite 25-u2010hydroxyvitamin D, which is either produced by skin exposure or the gut from oral intake. Vitamin D has been shown to a variety of health conditions, but debates persist over the precise form and extent of the drug, as well as whether associations are in the causal pathway. The workshop's aim was to clarify the role of vitamin D in human health and devise strategies to raise vitamin D status in the UK population.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/nbu.12557


The use of non‐vitamin K oral anticoagulants in dialysis patients—A systematic review

Non-u20vitamin K oral anticoagulants are used for prevention of thromboembolic events, but their use in dialysis patients is questionable. The current evidence for the use of NOACs in dialysis patients was reviewed in this research. With apixaban and rivaroxaban, less accumulation was noted in dialysis patients as compared to dabigatran and edoxaban. The comparison of rivaroxaban with VKA produced conflicting results, according to most cohort studies, with apixaban superior to VKA. According to Cohort studies, anapixaban high dose with low dose twice a day indicates a reduced risk of stroke with a higher risk of bleeding with high doses but also a higher risk of bleeding with high doses. Apixaban dosage versus no anticoagulation was compared in one cohort study and did not reduce the risk of stroke compared to non-u2010 patients, regardless of apixaban dose. Properly sized RCTs limit the widespread use of NOACs in dialysis patients.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/sdi.13098


Role of vitamin D3 in tumor aggressiveness and radiation response for hepatocellular carcinoma

We wanted to determine whether 150,000dihydroxyvitamin D3 plays a role in HCC's tumor initiation and radiation response in vitro and in vivo, as well as the underlying mechanisms. The human and murine liver cancer cell lines were used in cell and animal experiments to investigate the changes in tumor characteristics and radiation response after calcitriol supplementation. Following RT, the effects of calcitriol supplementation on interleukinu20106 signaling and the tumor immune microenvironment were also investigated. Following RT, calcitriol delayed the recruitment of myeloidu2010derived suppressor cell transplantation and increased the infiltration of cytotoxic T cells in tumors, raising the infiltration of cytotoxic T cells in tumors. Besides, when the primary liver tumor was treated with a higher dose per fraction, calcitriol created a smaller number of synchronous unirradiated tumor in mice, which was associated with attenuated ILu20106 signaling and MDSC recruitment.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/mc.23421


Vitamin B1 THIAMIN REQUIRING1 synthase mediates the maintenance of chloroplast function by regulating sugar and fatty acid metabolism in rice

Nonetheless, the precise role of VB1 in rice is uncertain. Despite an increase in the expression of VB1 synthesis genes, the VB1 content in cles was dramatically reduced. The decreased TPP content affected the tricarboxylic acid cycle, pentose phosphate pathway, and de novo fatty acid synthesis, resulting in a decrease in fatty acids and sugars of cles. Our research revealed that OsTH1 was an essential enzyme in VB1 biosynthesis and played a key role in seedling growth and development by playing in fatty acid and sugar metabolism, providing new insight into VB1 function in rice.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jipb.13283

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions