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During pregnancy, several hormones and elements are involved in the homeostasis of glucose metabolism. During the second trimester of gestation and the postpartum period, this present research established the differences between the factors involved in glucose regulation for pregnant women with and without an abnormal glucose challenge test, but not without gestational diabetes mellitus. The women in the odd GCT group had significantly higher levels of 25-OH-vitamin D and copper than those in the normal GCT group. Also, significant positive correlations existed between 25-OH-vitamin D and glucose after a 50-g GCT, 25-OH-vitamin D and HbA_1C, serum copper and glucose, and HbA_1C, among 25-g GCT, 25-g GCT, 25-OH-vitamin D and HbA_1C, serum copper and glucose, as well as serum copper and glucose after a 50-g GCT, and HbA_1C, We conclude that blood 25-OH-vitamin D and copper are highly correlated with gestational glucose levels; these two factors, in turn, are potential clinical indicators for maternal delayed glucose tolerance and, in turn, reducing neonatal risks and neonatal complications.
Source link: https://doi.org/10.1007/s12011-021-02920-x
Many studies have found no correlation between calcium intake and blood pressure, implying that calcium supplements could help reduce blood pressure. As a population group in which the use of calcium supplements is common, we examined the effect of calcium and vitamin D supplementation on the blood pressure of postmenopausal women with hypertension as a health group in which calcium supplement use is widespread. To record the initial and final blood pressure in all participants, we used 24-h ambulatory blood pressure monitoring. After eating calcium and vitamin D supplements, blood pressure rises were evident in both mean systolic and diastolic blood pressure. This means that calcium supplementation for postmenopausal women with hypertension, particularly in women treated with calcium channel blockers, must be closely monitored.
Source link: https://doi.org/10.1038/s41440-022-00930-3
Objects: Objectives: To determine the synergistic effects of vitamin D deficiency and sarcopenia on vertebral osteoporostic fracture in patients with rheumatoid arthritis, patients with rheumatoid arthritis. Using a u03c7 2 test and logistic regression, the synergism of sarcopenia and vitamin D deficiency on VF in patients with RA was tested. Results The prevalence of OP at all measured sites and VF in RA patients was all higher than those in controls. Whether you were looking for sarcopenia or with vitamin D deficiency in RA was higher than those without sarcopenia or without vitamin D deficiency. Age was a significant risk factor for VF in patients with RA, according to a logistic regression analysis, while high skeletal muscle mass was a protective factor for VF in RA patients. Vitamin D deficiency and Sarcopenia may be risk factors for the incidence of VF in RA patients.
Source link: https://doi.org/10.1007/s10067-022-06125-y
Objectives of the study The aim of the study is to determine the effects of active vitamin D supplementation on insulin resistance and islet u03b2-cell function in patients with non-diabetic chronic kidney disease patients. Methods Anonyms in the prospective controlled study The inclusion criteria were met by 60 patients in the non-dialysis group; 36, hemodialysis group; and 38, the peritoneal dialysis group. Mean HOMA-IR value of the experimental group significantly reduced significantly compared to that of the control group after 3 months of intervention. Mean HOMA-u03b2 index: Mean HOMA-u03b2 index in the ND group was higher than that of the control group after 1 month of active vitamin D therapy, but with an extended intervention period, the index gradually increased P.
Source link: https://doi.org/10.1007/s11255-021-02968-7
Vitamin D metabolites are primarily determined as a status marker or for diagnostic use, and it is almost entirely based on blood serum or plasma. Alternative matrices have piqued attention for two primary reasons: alternative matrices can be used for non-invasive sampling, facilitate sample exchange, and minimize less stringent storage conditions; and vitamin D metabolites present in other body compartments may contribute to increased knowledge of vitamin D metabolism and function.
Source link: https://doi.org/10.1007/s00216-022-04097-1
Supplementing vitamin D has been shown to be safe in promoting neurogenesis and neuronal survival in comparison to stem cells. Mutational variants and single-nucleotide polymorphisms of the vitamin D receptor in neurological disorders have also been reported by studies; however, the effects of these mutations in the pathophysiology and response to drug therapy are yet to be explored. Hence, we have reviewed recent research relating to the role of neural stem cells and VDR-mediated cellular signaling cascades that are key to neurogenesis enhancements by Wnt/u03b2-catenin and Sonic Hedgehog pathways in this paper.
Source link: https://doi.org/10.1007/s12035-022-02837-z
This open-label, block-randomized controlled trial compared the use of 800 IU/day and 400 IU/day of oral vitamin D_3 supplementation in lowering vitamin D insufficiency in healthy breastfed infants at 14 weeks of postnatal age at 14 weeks of postnatal age. What is New: AUG2022 800 IU/day of oral vitamin D3 supplementation in term breastfed infants dramatically reduces vitamin D insufficiency at 14 weeks of age, as compared to the recommended dose of 400 IU/day.
Source link: https://doi.org/10.1007/s00431-022-04533-5
Introduction Considering vitamin D's anticoagulant activity, we hypothesize that vitamin D status might influence the dosage of warfarin required to maintain the therapeutic international normalized ratio. For measuring the warfarin dose response, the warfarin dose response was measured by a warfarin sensitivity scale, which is defined as the steady-state INR divided by the mean daily warfarin dose. The relationship between the serum level of 25-hydroxyvitamin D and the difference in the mean WSI value between the subjects with different vitamin D status categories was investigated. According to those with greater vitamin D status classes regarding the mean WSI value, there was a trend in a significant difference between the groups with different vitamin D status classifications regarding the mean WSI score, as well as those with elevated vitamin D deficiency had a higher WSI value.
Source link: https://doi.org/10.1007/s40119-022-00268-4
An rise in the incidence of cardiovascular disease is associated with an increase in the occurrence of cardiometabolic events, but evidence of this connection in adolescence is still limited. Hence, we investigated the connection between vitamin D deficiency and cardiometabolic risk factors in adolescents. As a summary measure, random effects models were used to summarize standard mean differences for as a summary statistic. A total of 7537 studies had been published, of which 32 were included in the systematic review and 24 in the meta-analysis, with an increase in the HOMA index, elevated triglyceride levels, and reduced HDL levels. For glycated hemoglobin, LDL cholesterol, and total cholesterol, no statistically significant association was found. Vitamin D deficiency was linked to a rise in the risk of cardiometabolic diseases in adolescents, owing to increased exposure to the conditions that contribute to the occurrence of cardiometabolic disorders in adolescents.
Source link: https://doi.org/10.1007/s11154-022-09736-7
Osteoarthritis is a leading cause of pain and disability worldwide. To help reduce and prevent OA, we recommend the use of alendronate as a disease suppressing agent. Therefore, a placebo-controlled, randomized trial is required to determine the combined effects of alendronate and vit D on cartilage's structure, as well as its ability to treat knee pain in OA patients. Between both groups, the main outcome is to determine the WORMS score of knee joint at 6 and 12 months. Discussion This trial will present useful and high-quality data on the potential therapeutic role of alendronate sodium vitamin D3 in the treatment of patients with knee osteoarthritis, radiographic progression of OA, knee pain, quality of life, and inflammatory biomarkers.
Source link: https://doi.org/10.1186/s12891-022-05521-4
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