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Vitamin D - Europe PMC

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Last Updated: 22 June 2022

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Corrective osteotomy for complex tibial deformity in a patient with hereditary vitamin D-resistant hypophosphatemic rickets (HVDRR) using CT-based navigation system and 3D printed osteotomy model.

Planning a three-dimensional osteotomy using computed tomography results is particularly helpful in cases of complicated deformities. However, one drawback when using navigation devices is that osteotomies are performed on tracker-attached bone, bone fragments on the side that were cut away cannot be traced. A mature man's tibial deformity with intramedullary nail fixation led to segmental corrective osteotomy. We used these methods to achieve segmental corrective osteotomy for a difficult tibial deformity with intramedullary nail fixation case of hereditary vitamin D-resistant hypophosphatemic rickets. To shield the thin and stretched skin around the deformed tibia, we decided to use an IMN for correction and fixation of tibial deformity. In addition, we may be able to provide accurate preparation of closed medullary canal for the IMN placement by referring to the 3D printed bone models. The bone union at the osteotomy sites had been confirmed six months after the surgery, and the patient was able to return to his normal life and work.

Source link: https://europepmc.org/article/MED/35727185


1α, 25-Dihydroxyvitamin D3 protects gastric mucosa epithelial cells against Helicobacter pylori -infected apoptosis through a vitamin D receptor-dependent c-Raf/MEK/ERK pathway.

Unknown role of 1u03b1, 25-dihydroxyvitamin D3 in H. pylori -infected gastric mucosa epithelial cells remains unclear. The purpose of this research is to determine the protective property of 1,25-D3 against H. pylori-infected apoptosis in gastric mucosa epithelial cells and its potential molecular mechanisms. Materials and methods Every other day for 1 month, Mice were orally gavaged with 10 8 CFUs of H. pylori and 25 g/kg 1,25-D3. H. pylori infection reduced cell viability to 59. 2%, while 100-300 nM 1,25-D3 raised cell viability to 62. 2%, 78. 4%, and 87. 1%, respectively. Using a VDR-dependent c-Raf/ERK pathway, a 1,25-D3 covered gastric mucosa epithelial cells against H. pylori-infected apoptosis caused by a VDR-dependent c-Raf/MEK/ERK pathway, resulting in a H. pylori-infected apoptosis.

Source link: https://europepmc.org/article/MED/35587225


Vitamin D/vitamin D receptor/Atg16L1 axis maintains podocyte autophagy and survival in diabetic kidney disease.

Objectives: To determine the effects of vitamin D/vitamin D receptor/Atg16L1 signaling on podocyte autophagy and survival in diabetic nephropathy. In the absence or presence of 100 nmol/L calcitriol, the murine podocyte cell line MPC-5 was cultured under hyperglycemic conditions to investigate podocyte injury and autophagy. Calcitriol therapy reduced renal injury in rat diabetic kidneys and reduced high glucose-induced damage to cultured podocytes. Atg16L1 was a functional target of VDR, and siRNA-mediated knockdown of VDR and Atg16L1 prevented the protective effects of aVitD3 against podocyte damage, according to Mechanistically, and damage caused by podocyte damage.

Source link: https://europepmc.org/article/MED/35469547


Reversibility of pancreatic β-cells dysfunction after vitamin D and calcium supplementation: a pilot study in a population of obese and prepubescent North-African children.

This research sought to determine the effects of vitamin D and calcium supplementation on pancreatic u03b2-cells' function in terms of insulin secretion and sensitivity. During three months, the children were provided with calcium and vitamin D supplementation in therapeutic doses. An oral glucose tolerance test was administered both at the start and at the end of the study. i hyperinsulinism: insulinemia sum > 300 IU/ml during OGTT, ii insulin-resistance: homeostatic model assessment of insulin-resistance > 2, ii insulin-resistance: normal plasma levels during OGTT without any spike, and iv pancreatic dysfunction reversibility: disappearance of the aforementioned disorders. After calcium and vitamin D supplementation, as well as insulin-secretion, the glycaemic profile and insulin-secretion improved greatly p 0. 0001. To conclude, vitamin D and calcium supplementation in obese and prepubescent children resulted in the reversibility of pancreatic u3b2-cell dysfunction.

Source link: https://europepmc.org/article/MED/35388742


Effects of vitamin C and D on the mRNA expression of angiotensin converting enzyme 2 receptor, cathepsin L, and transmembrane serine protease in the mouse lungs.

Through attachment to angiotensin converting enzyme 2 receptor and the proteolytic activity of Cathepsin L and transmembrane serine protease 2 enzymes, the SAR-CoV-2 virus penetrates the pulmonary endothelial cells. This research was conducted to determine the effects of Vit C and D on the mRNA expression of Ace2, Tmprss2, and Ctsl genes in mouse lungs. Vit D, but not C, upregulated Ace2's mRNA expression by more than six folds, while Tmprss2 genes were downregulated by 2. 8 and 2. 2 folds, respectively.

Source link: https://europepmc.org/article/MED/35311495


Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?

Multiple sclerosis is an autoimmune disease with a symptomatic but not curable disease. Multiple sclerosis therapy is available in a variety of ways, including a class entitled disease-modifying agents that are mainly shown to reduce the number and severity of disease relapses. We recapitulated the common immunopathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis, the immunomodulatory and neuroprotective properties of vitamin D, and the state-of-art concerning its supplementation to multiple sclerosis patients in this study.

Source link: https://europepmc.org/article/MED/35142671


Streptozotocin-induced Diabetes Represses Hepatic CYP2R1 Expression but Induces Vitamin D 25-Hydroxylation in Male Mice.

Cyp2r1 and vitamin D status were specifically investigated by us. Cyp2r1 in mice is reduced by streptozotocin-induced diabetes, according to our study. Although insulin therapy normalized the blood glucose levels in the diabetic mice, it did not resolve the diabetes-induced inhibition of Cyp2r1. Moreover, vitamin D 25-hydroxylase enzyme activity in the diabetic mice's livers had been increased, suggesting compensation for the Cyp2r1 repression by other vitamin D 25-hydroxylase enzymes. After 4 weeks of diabetes, the vitamin D1-hydroxylase enzyme expression in the kidney and the plasma 1u03b1,25-dihydroxyvitamin D level were elevated, although both were normalized after 13 weeks. These findings, however, show that in the mouse model of type 1 diabetes regression of hepatic Cyp2r1 expression, decreased hepatic vitamin D 25-hydroxylase production and vitamin D deficiency did not result in reduced hepatic vitamin D 25-hydroxylase activity and vitamin D deficiency.

Source link: https://europepmc.org/article/MED/35524739


Vitamin D Metabolites, Body Composition, and Nutritional Status in Patients in the Long Term After Kidney Transplantation.

BACKGROUND The aim of the study was to determine the correlation between body composition and nutritional status in patients with the presence of vitamin D metabolites 25D and 1,2582D in patients in the long run after kidney transplantation. METHODS HEMATICAL AND METHODS The anthropometric and body composition measurements, as well as laboratory results from 105 stable KTx patients were collected and evaluated during two routine outpatient visits in summer and winter. A reverse correlation between the 25D level and fat tissue index was found. Body cell mass and lean tissue mass measurements were both elevated along with body cell counts and lean tissue mass values, which were along with body cell mass and lean tissue mass measurements. CONCLUSIONS Body composition is one of the key factors influencing vitamin D status in KTx patients. After KTx, fat tissue index is a poor predictor of a 25D-level in patients in the long run.

Source link: https://europepmc.org/article/MED/35726175


800 IU versus 400 IU per day of vitamin D 3 in term breastfed infants: a randomized controlled trial from an LMIC.

This open-label, block-randomized controlled trial compared the use of 800 IU/day and 400 IU/day of oral vitamin D3 supplementation in reducing vitamin D insufficiency in healthy breastfed infants at 14 weeks of postnatal age at 14 weeks of postnatal age. Conclusions: Vitamin D3 supplementation with 800 IU resulted in a nearly 50% decrease in the number of infants with VDI and averted the occurrence of severe VDD at 14 weeks of age compared to 400 IU with no evidence of vitamin D toxicity. What is New: u2022 800 IU/day of oral vitamin D3 supplementation among term breastfed infants significantly reduced vitamin D insufficiency at 14 weeks' age, relative to the recommended dose of 400 IU/day.

Source link: https://europepmc.org/article/MED/35726033


Influence of Vitamin D Status on the Maintenance Dose of Warfarin in Patients Receiving Chronic Warfarin Therapy.

Introduction Given the anticoagulant properties of vitamin D, we hypothesize that vitamin D status would influence the recommended dose of warfarin for maintaining the therapeutic international normalized ratio. For measuring the warfarin dose response, a warfarin sensitivity index, based on the mean daily warfarin dose, was used. The correlation between the serum level of 25-hydroxyvitamin D and WSI value, as well as the difference in the mean WSI value between the subjects with different vitamin D status classifications was investigated. There was a trend in a significant difference between the two groups with different vitamin D status levels regarding the mean WSI value, as participants with high vitamin D state compared to those with vitamin D deficiency had a higher WSI score.

Source link: https://europepmc.org/article/MED/35718837

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions