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While a common dietary-based approach to improving iron status has been widely used, a shortage exists in random controlled trials to establish the effect of vitamin D-fortified juice on iron status recovery. Thus, this review seeks to determine the impact of an 8-week vitamin D3-fortified fruit juice supplementation on iron status measurements in childbearing-aged women with marginally low iron stores. A mixed model repeated-measures analysis of variance will be conducted to determine the effects of the intervention and the correlation with time points for all iron and vitamin D status blood biomarkers. Discussion: Vitamin D supplementation in food fortification as a novel iron absorption enhancer could be a future and useful alternative to iron deficiency therapy with poor adherence, in comparison to the oral iron therapy that has poor adherence.
Source link: https://doi.org/10.1371/journal.pone.0265772
Vitamin A Supplementation is a cost-effective way to reduce mortality among children aged 6–59 months in low-income countries. We calibrated the model with disease and risk factor estimates from the Global Burden of Disease 2019. After the model was tested against GBD inputs, we constructed an alternative scenario where we scaled-up VAS coverage from 2019 to a level that halved the number of VAS in 2023. The DALYs averted per 100,000 person-years in N. . . . ia, 21 [5, 47] DALYs averted per 100,000 person-years, and 14 [0, 37] DALYs averted per 100,000 person-years in Burkina Faso, averted per 100,000 people-years in Burkina Faso, who were averted per 100,000 person-years averted per 100,000 people-years in N. . . . ia, 21 [5, 56] a afaverted per 100,000 averted per 100,000 people-years in Burkinaverted per 100,000] averted per 100,000 averted per 100,000 person-years averted per 100,000 per 100,000 ad averted per 100,000 averted per 100,000 averted per 100,000 person-years a fis a fis a Fas a Fas a fis a fis a Fas a fiafafa fis afa fis afa fis afafa fis afa fis a fis a fi.
Source link: https://doi.org/10.1371/journal.pone.0266495
There is little information on the effects of environmental exposure to arsenic on adults's immune system. We found that UAs and DMA+3/+5 were both associated with increases in Th17 cell counts in a nonlinear manner in non-smoking women. We discovered a modest decrease in Th17 cell numbers in those with inadequate and inadequate vitamin D levels when stratified by vitamin D levels as both adequate and ineffective. Individuals with high VitD levels showed significant decrease in IL-17A production in non-smoking males.
Source link: https://doi.org/10.1371/journal.pone.0266168
Background: According to observational studies, vitamin D deficiency among people living with HIV is associated with a greater risk of disease progression and death. Poor fetal and infant growth have also been associated with low vitamin D deficiency in pregnancy. Vitamin D supplementation could also promote fetal and postnatal growth for infants, as a result of maternal and postnatal growth. Methods and findings: We conducted a double-blind, placebo-controlled trial of vitamin D3 supplementation in Dar es Salaam, Tanzania, among pregnant and lactating women living with HIV. Participants were randomly assigned by study clinic to receive either daily 3,000 IU vitamin D3 supplements or equivalent placebo supplements from the second trimester of pregnancy to 1 year postpartum. We also looked at the effects of vitamin D3 supplementation on secondary maternal and infant health outcomes, maternal and infant serum 25-hydroxyvitamin D concentrations, and maternal hypercalcemia. There was no difference between the vitamin D3 and placebo groups in terms of SGA birth risk. There was also no difference in the risk of infant stunting at 1 year of age between the vitamin D3 and placebo groups. Conclusions: The trial findings do not recommend routine vitamin D supplementation for pregnant and lactating women living in Tanzania with HIV. Christopher R. Sudfeld and colleagues investigate the effect of vitamin D supplementation on pregnant women living with HIV and infant growth results.
Source link: https://doi.org/10.1371/journal.pmed.1003973
Objective: To determine the effects of oral vitamin A supplementation on pediatric outcomes. Only random controlled trials looking at the effects of oral vitamin A on premature babies were included in this study. To grade evidence quality and determine how oral vitamin A supplementation affects clinical outcomes, we used the GRADE system to classify evidence quality and determine how oral vitamin A supplementation impacts clinical outcomes. The primary findings were respiratory disease, respiratory support, the desire for oxygen at 36 weeks postmenstrual age, and moderate-to-severe bronchopulmonary dysplasia at 36 weeks PMA. Oral vitamin A therapy was compared to a placebo in all trials. Conclusions: Administering oral vitamin A to premature infants did not reduce the mechanical ventilation time, oxygen consumption, or short-term benefits at 36 weeks PMA, death, or short-term benefits. However, oral vitamin A supplementation may little influence the duration of noninvasive respiratory support without triggering adverse drug-related events.
Source link: https://doi.org/10.1371/journal.pone.0265876
The toxicity mechanisms of VEA vaping are still not fully understood nearly two years after vitamin E acetate was identified as the potential cause of the 2019–2020 outbreak of e-cigarette, or vaping product-associated lung injuries. However, the effect of heating coil temperature on the chemical composition of VEA vaping emissions has yet to be fully investigated. In addition, inconsistent product delivery was observed in VEA degradation products produced from vaping and from pyrolysis using a tube furnace in the absence of the heating coil at equivalent temperatures, indicating the presence of external influences such as metals or oxidation that could raise VEA degradation during vaping. Overall, our results show that vaping habits could have a big influence on the likelihood of exposing to dangerous vaping products and potential for vaping-related health issues.
Source link: https://doi.org/10.1371/journal.pone.0265365
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