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SAR-CoV-2 virus embeds into the pulmonary endothelial cells by binding to angiotensin converting enzyme 2 receptor and Cathepsin L's proteolytic enzyme 2 receptor, as well as transmembrane serine protease 2 enzymes. This study was conducted to determine the effect of Vit C and D on the mRNA expression of Ace2, Tmprss2, and Ctsl genes in mouse lungs. Both Vit D, but not C, upregulated Ace2's mRNA expression by more than six folds, while Downregulated the expression of Ctsl and Tmprss2 genes by 2. 8 and 2. 2 folds, respectively.
Source link: https://europepmc.org/article/MED/35311495
Today, natural bioactive compounds in aquaculture feeds are used to enhance fish health and consequently improve fish health, thus increasing the quality and sustainability of fish raising. The present research was conducted to compare the effects of dietary vitamin C, thyme essential oil, and quercetin levels on common carp, Cyprinus carpio's hematology, antioxidant, and immune parameters. An increase in white blood cells was found in the treatment groups after the 60-day feeding trial, in comparison to that of the control group. Hemoglobin and mean corpuscular hemoglobin concentrations were both significantly influenced by the TE therapies. In fish fed dietary additives, Malondialdehyde production was significantly lower than that of fish-fed dietary additives. Also, serum and liver enzyme values, such as Alanine transaminase, alkaline phosphatase, and aspartate transaminase in fish fed the experimental diet were significantly lower than those in fish that were not fed the control diet.
Source link: https://europepmc.org/article/MED/IND607677603
Glioblastoma is one of the most common brain tumors. We hypothesized that GB cells preferentially take up DHA, which is intracellularly reduced and compartmentalized into the endoplasmic reticulum, favoring collagen biosynthesis and an aggressive phenotype. Our findings revealed that GB cells produce DHA using GLUT1, while GLUT3 and sodium-dependent vitamin C transporter 2 are preferrably intracellular. Ascorbic acid was compartmentalized, boosting collagen IV secretion and increasing in vitro and in situ cell migration. Vitamin C deficiency-treated collagen, reduced blood vessel invasion, and affected glomeruloid vasculature formation, among other pathological signs related to malignancy, according to the endoscopy of immunocompetent guinea pigs. Vitamin C is a key component of GB growth and progression, according to us. Collagen, which is partially secreted by tumor cells, promotes the development of the glomeruloid vasculature and promotes perivascular invasion.
Source link: https://europepmc.org/article/MED/35166128
Ascorbic acid can be synthesized by many metabolic pathways in plants, but there is still a lot to learn about their integration and control mechanisms. Here we introduce the first crystal structure for an L-galactose dehydrogenase from the D-mannose/L-galactose pathway, which converts L-galactose to L-galactose. The enzyme's kinetic parameters are similar to those from its camu-camu sil, a super-accumulator of vitamin C discovered in the Peruvian amazon's. As a result of ascorbic acid concentration, changes in the pH of the reaction medium may have influenced previous publications. As used by several AKRs, the structure bound to NAD + confirms that the absence of Arg279 shows that the absence of Arg279 supports its choice for NAD + over NADP+. The present work contributes to a more complete analysis of enzyme-function relationships in vitamin C synthesis's structure-function relationships.
Source link: https://europepmc.org/article/PPR/PPR483056
Lessening Organ Dysfunction with VITamin C is a blinded multicentre controlled clinical trial in patients admitted to the intensive care unit with proven or suspected infection as the main diagnosis and receiving a vasopressor. Findings The SAP includes a draft participant flow diagram, tables, and estimated figures. At 28 days, the primary result is a mixture of mortality and persistent organ dysfunction, where day 1 is the day of randomization. Considering the site as a random effect and adjusting the number and 95% confidence interval in a generalized linear mixed model with binomial distribution and log link, as well as considering location as a random effect. Conclusions We have developed a SAP for the LOVIT trial and will adhere to it during the analysis phase.
Source link: https://europepmc.org/article/MED/35420994
Background: Prostate cancer ranks second in the cancer of male patients worldwide. Vitamin C's action on prostate cancer prevention is uncertain, according to this meta-analysis and Mendelian randomization, and previous studies showed conflicting conclusions about the clinical relationship between vitamin C and prostate cancer. Outcome results of prostate cancer research were published by Prostate Cancer Association Group to Investigate Caner-Associated Alterations in the Genome and FinnGen project, which attracted 208,525 participants. Vitamin C supplementation and prostate cancer incidence were not significant, according to the pooled effect. Both the results of MR provided insufficient evidence to back up the causal connection between plasma vitamin C and prostate cancer, as well as the findings from the PRACTICAL and FinnGen project. Conclusions: The results of meta-analysis and MR analysis showed there were no signs that neither vitamin C supplementation nor plasma vitamin C level were related to prostate cancer.
Source link: https://europepmc.org/article/PPR/PPR481308
After dividing the participants into two groups based on serum cotinine levels, Poisson regression analysis was carried out to compare vitamin C levels with the prevalence rate ratio for each group based on serum cotinine levels. After adjusting for sex, the use of interdental brushes or dental floss, and the number of teeth, we investigated variations in serum vitamin C tertiles between participants with elevated or low serum cotinine levels. For both groups, there was a negative correlation between the PRR of vitamin C tertiles and the PPD or CAL. The PRR of the first tertiles in the high serum cotinine group was 5. 03, compared to 2. 69 in the low serum cotinine group.
Source link: https://europepmc.org/article/MED/35415888
Cultured meat technology is a promising alternative to animal protein production that enjoys its convenience, safety, and sustainability. The muscle stem cell is one of the most important seed cells for making muscle fibers, but its ineffective ex vivo proliferation capability limits the industrialization of cultured meat. Vitamin C is an excellent supplement for porcine MuSCs ex vivo's long-term culture with significant proliferative and myogenic properties, as shown here. The total cell number in pMuSCs increased by 2. 8 10 7 0. 6 10 7 xfold after 29 days of culture with 100 %M VC, which was 360 times higher than that of cells without VC treatment. pMuSCs exposed to VC were less likely to be arrested in the 0/G1 period, but they did not detect a significant rise in the expression of cell cycle-related genes such as Cdk1, Cdk2, and Ki67.
Source link: https://europepmc.org/article/MED/35411884
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