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Vitamin C is a weak sugar acid structurally related to glucose and is insoluble in Vitamin C. Vitamin C can be used as an antioxidant at low levels, according to in vitro studies, although a high concentration is pro-oxidant. As a result, both AA's characters can be converted into clinical services. However, clinical evidence for high-dose intravenous vitamin C's therapeutic effect is uncertain, and In vitro findings and murine experiments demonstrate the cytotoxic effects of AA on cancer cells. There are several publications on vitamin C and cancer in the literature. We reviewed 20 publications related to high-dose intravenous vitamin C therapy based on the results of four review papers and the National Cancer Institute's Cancer Information Summary. According to the published findings, HAAT might be a useful cancer-treating device in some situations. We believe that the clinical use of HAAT in cancer treatment should be revisited.
Source link: https://doi.org/10.3390/ijms23084380
Patients with leukemia and lymphoma are being treated with allogeneic and autologous transplantation of hematopoietic stem cells. For that, we investigated the effects of vitamin C and D on the physiology of cytomegalovirus-specific T cells isolated from CMV-seropositive healthy donors. Vitamin C was found on cells isolated from male donors and donors over 40 years old, increasing the expansion and activation state of CMV-specific T cells, as well as a rise in the popularity of vitamin C. Here's a glimpse at the impact of vitamin C on cytotoxic T cells, as well as potential new selection criteria and methods to enhance VST stability.
Source link: https://doi.org/10.3390/biology11040536
The present research was done to investigate the potential benefits of vitamin C and thiamine on lead accumulation in kidney, liver, muscle, and gill of experimentally lead-poisoned common carp. During lead acetate exposure, groups 2, 3, and 4 were exposed to lead acetate, while groups 3 and four were exposed to lead acetate; respectively, groups 3 and 4. Following this, it was discovered that lead exposure led to a significant rise in lead content in all examined tissues of fish in group 2 in comparison to the control group. In the same way, vitamin C supplementation reduced the augmented concentrations of lead in the muscle to levels that were not significantly different from those of the control group. When compared to group 2's findings, neither thiamine nor vitamin C was able to reduce tissue lead burden in groups 3 and 4 as compared to group 2.
Source link: https://doi.org/10.22067/veterinary.v9i1.53864
Albino mice were randomly divided into seven groups: the control group, which received only normal saline; the MTX group; pretreated with VC for ten days; and the CUR group, which received VC and CUR; and the combined group, which received VC and CUR; and the CUR group, which received VC and CUR; Pretreatment with VC and CUR led to a significant decrease in alanine transaminase, aspartate transaminase, alkaline phosphatase, and lactic dehydrogenase, as well as a substantial decrease in histopathological changes in liver tissues, demonstrating the potential hepatoprotective effects of the combination therapy on MTX-induced liver injury, according to the authors. However, the combined effect of VC and CUR provided a synergistic hepatoprotective effect that outperforms CUR alone, but it does seem to be similar to that of VC 200 mg/kg/day.
Source link: https://doi.org/10.3389/fmed.2022.866343
Pneumonia patients with vitamin C may have less frequent symptoms and a longer course of the disease if they do. Vitamin C's use in the COVID-19 treatment protocol in China and the United States has shown promising results when using a high percentage of intravenous vitamins C. It's easy to include vitamin C in the COVID-19 treatment protocol as a secondary measure based on the most recent valid clinical research examining the effect of vitamin C on COVID-19's management. The study's aim was to see if high dose intravenous vitamin C had any effect on people with extreme COVID-19. The aim of this paper is to summarize existing research on the benefits of vitamin C as a treatment for COVID-19 and to explore potential explanations for why it works in some people but not in others.
Source link: https://doi.org/10.3934/microbiol.2022010
The aim of this research was to determine the quality of frozen-thawed bull semen treated with extenders that contain vitamin C and E as antioxidants. By the addition of 1 million vitamin C and 0. 1 mM vitamin E to a CEY extender, dramatic reductions of LPO were achieved. Compared to the control group, supplementing CEY extender with 2mM vitamin C and 0. 1 million mg vitamin E improved the sperm motility. Vitamin C and E are highly effective antioxidants in CEY extender, according to the present findings.
Our results: Our findings revealed that intrahippocampal injection of ethidium bromide destroys PAL's PAL by a substantial amount. Lower doses of progesterone did not affect latency, but a dose of 1 g/l significantly raised STL. The Infusion therapy group STL was significantly more than the lesion group in comparison to the vitamin C group, but it was not significantly different from the vitamin C group. Conclusion: We found that vitamin C injection intrahippocampal increases memory for PAL's memory, but that alone or in combination with vitamin C had no effect on memory.
Source link: https://doi.org/10.5681/apb.2015.011
Abstract Background The thyroid physiology is closely related to oxidative changes. Methods This controlled review of Se included 1401 people in the following categories: benign thyroid disease, benign thyroid disease, and malignant thyroid disease. There should be no differences in the antioxidant levels between controls and thyroid disease patients, according to H o. Among the thyroid disease patients, neither vitamin C, nor Zn nor Se were correlated with any of the following variables: age, sex, BMI, body height, thyroid scintigraphy, ultrasound pattern, thyroid function, or thyroid antibodies. Vitamin C; 8. 8% for Zn; and 20. 3% for Se were 8. 7% of patients with benign thyroid diseases with analyte concentrations below external reference cut off standards. Patients with benign or malignant thyroid disease may have lower Se levels compared to controls.
Source link: https://doi.org/10.1186/1472-6823-8-2
Methods: This research was conducted in a cross-sectional study of 85 patients admitted to cataract surgery, aqueous and blood were collected right before surgery under general anesthesia from anterior chamber and vein, respectively. Both sexes were equal in both genders, but vitamin C of plasma in women was higher than males. Vitamin C levels in senile cataract's serum and plasma were found to be no relation to the type of cataract. Conclusions: Vitamin C levels in aqueous and plasma were no different than those of normal.
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