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Background and purpose Cerebral venous sinus thrombosis is a rare cerebrovascular disease with a wide variety of clinical manifestations. The purpose of this research is to investigate the presence of subarachnoid hemorrhage in the context of CVST and to discuss its epidemiological, atomic, and laboratory aspects. Methods Between October 2012 and October 2019, 43 patients with CVST were surveyed between October 2012 and October 2019. SAH was found in a quarter of the patients treated with CVST. The most common risk factor was oral contraceptives, and headache was the most common symptom. Both sinuses, the superior sagittal sinus, and the transverse sinus, were the most affected. In one instance, the location of SAH was in the cerebellum and in two cases during the Sylvian fissure. Following 6 months of therapy, seven patients improved greatly with anticoagulation. Conclusions This survey found that 25. 5 percent of patients with CVST had SAH.
Source link: https://europepmc.org/article/MED/36070172
Objctive (cerebral) thrombosis is a condition that causes severe hemorrhagic disease. We set out to chronicle mechanical thrombectomy using tandem stent-retrievers and intermediate catheter aspiration. Methods All refractory SH-CVST patients treated with MT using TDSA in our hospital were retrospectively reviewed. MT-TDSA is a method that completely engages the clot with double stent-retrievers and retrievs the clot with double stent retrieval from an intermediate catheter. Resluts are a patient with refractory SH-CVST were treated with MT-TDSA between January 2016 and January 2020. Resluts is a television showpiece The earliest patients with refractory SH-CVST were treated with MT-TDSA between January 2016 and January 2020.
Source link: https://europepmc.org/article/MED/36058490
Background Multiple studies have sought to identify predictors of poor clinical outcomes in cerebral venous thrombosis. Fewer studies aim to identify predictors of poor response to anticoagulation therapy in CVT. Objective We sought to determine the predictors of poor clinical response to therapeutic anticoagulation in patients with acute CVT. The PRACT-CVT score was determined by bivariate and multivariate studies, which indicated risk of acute CVT in anticoagulated patients, and we used the identified variables to produce the PRACT-CVT score. Patients with acute CVT age > 65 or ten years old, with focal motor dysfunction after admission, experiencing acute neurotoxication during hospitalization, experiencing brain bleeding/ischemia on initial neuroimaging, involvement of the superior sagittal sinus, or presence of both transverse sinuses had poor reactions to anticoagulation. Clinicians may use the PRACT-CVT score to predict poor response to anticoagulation for acute CVT.
Source link: https://europepmc.org/article/MED/36058024
Introduction Coronavirus disease 2019 is a common cause of acute thrombosis. We present a case report about a patient with cerebral venous sinus thrombosis related to COVID-19, as well as a literature review of CVSTs related to COVID-19 cases. Case report A 38-year-old woman was admitted with severe headaches and acutely altered mental condition a week after being diagnosed with COVID-19. We found 43 patients with CVST associated with COVID-19 infection in 43 patients. CVST diagnosis was 15. 6 to 13. 7 days after the onset of COVID-19 signs, according to the reporter. Conclusion In this COVID pandemic, CVST should be in the differential diagnosis when patients present with acute neurological signs. Early diagnosis and prompt treatment are often important to these patients' outcomes, and the mortality risk of CVST related to COVID-19 can be high.
Source link: https://europepmc.org/article/MED/34855659
Although hyperactivation of the immune system is a common precursor to the emergence of thrombotic events in both vascular systems, the main molecular control points remain unclear. We discovered the transcription factor Kru00fcppel-like factor 2 as a key regulator of neutrophil activation using antiphospholipid antibody syndrome as a model for arterial and venous thrombosis. Neutophils clustered P-selectin glycoprotein ligand 1 by cortical actin renovation, thus raising adhesion risk at sites of thrombosis. In APS and KLF2 knockout models, targeting activated neutrophils attenuated neutrophil-mediated thrombosis, demonstrating the importance and feasibility of targeting activated neutrophils to avoid pathological thrombosis. Our findings establish a role for activated neutrophils in both arterial and venous thrombosis, as well as identify key molecular events that may be useful for immunothrombosis targets against a variety of causes of immunoglobophilic disease.
Source link: https://europepmc.org/article/MED/36044595
Snakebite is a life-threatening and often-neglected public health risk that is largely affecting rural populations in the tropics/subtropics. However, cerebrovascular abnormalities have rarely described cerebral venous sinus thrombosis. Following Russell's viper bite, we present a previously healthy middle-aged Indian woman who suffered cerebral venous sinus thrombosis in the onset of disseminated bleeding diathesis.
Source link: https://europepmc.org/article/MED/36041514
Background: The Dural Arteriovenous Fistulas secondary to cerebral venous sinus thrombosis are extremely unusual. Results Five patients with DAVFs following CVST were included in the study. Ten patients were male and 6 patients were female, while six patients were female. Mean time from diagnosis of CVST to DAVF confirmation was 97 days. The most common symptoms of DAVF following CVST were headache and visual disturbance seen in 7 patients respectively. In seven patients, Board type II and III, respectively, in four patients, respectively, Angiography of DAVFs revealed Board type I in seven patients, Board type II and III in four patients. In seven, Cognard IIa and IV patients, IIb and III in one patient, respectively, the Cognard I was noted in Cognard IIa and IV. In six patients, the main feeding arteries of DAVFs most commonly arise from the branches of the external carotid artery. During follow-up, fourteen patients were treated with endovascular embolization, and none of the patients had persistent deficits.
Source link: https://europepmc.org/article/PPR/PPR536854
Both hormonal contraceptive agents and hormone replacement therapy for menopause and gender transition are seen in the risk of Thrombosis. Results Thrombosis risk with estrogen-containing drugs rises as the systemic dose of estrogen rises. While progesterone-only-containing drugs are not linked to thrombosis in combined oral contraceptives, when mixed with estrogen in combined oral contraceptives, the risk can be affected by the formulation of progesterone. Anticoagulation is anticoagulant against future thrombosis in patients who experience thrombosis due to hormonal therapy. This is perhaps the most effective way to treat hormone therapy for people with thrombotic disorders such as COVID-19. Conclusions: Clinicians must consider a variety of risk factors, including hormonal type, dose, route, personal and family history of thrombosis, and other prothrombotic risk factors in order to make informed, personalized decisions regarding venous thrombosis risk.
Source link: https://europepmc.org/article/MED/36032216
based on recent findings of the Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis randomized clinical trial, endovascular treatment for cerebral vein thrombosis has not been shown to be more effective than anticoagulation. In CVT, the aim is to compare the results of EVT vs. medical management. Methods We compared EVT vs. medical treatment in a retrospective multinational cohort of consecutive patients with CVT from 4 countries and 27 centers, using propensity score matching and inverse probability treatment weighting, and meta-analyzed the results with the TO-ACT trial. With IPTW, a rise 90-day rise in modified Rankin Scale and mortality, but there were no other significant differences between secondary outcomes with PSM or IPTW. A meta-analysis of primary and secondary outcomes from anticoagulation therapy in cerebral venous thrombosis showed no significant correlation with EVT in primary or secondary outcomes.
Source link: https://europepmc.org/article/MED/36001776
Aims An efficient cerebral venous sinus thrombosis model is vital for investigating its pathophysiology. Methods An 138 male Sprague-Dawley rats were randomly divided into semi-ligation and non-semi-ligation groups, according to a logical number. In the semi-ligation group, cardiovascular dysfunction, short-term and long-term neurological impairment, were more severe, than in the non-ligation group, thrombus weight, venous infarction volumes, and microglia activation were more apparent. Conclusions and Conclusions Semi-ligation, ferric chloride, and thrombin can result in a robust CVST model with multiple venous sinus involvement that is useful for short and long-term neurological and cognitive dysfunction analysis.
Source link: https://europepmc.org/article/MED/36000206
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