Advanced searches left 3/3

Vasculitis - PubMed

Summarized by Plex Scholar
Last Updated: 27 August 2022

* If you want to update the article please login/register

Molecular mechanisms of endothelial dysfunction in Kawasaki-disease-associated vasculitis.

Kawasaki disease is an acute, inflammation-mediated vasculitis disorder that is primarily affecting children under the age of five, and it is classified as the most common coronary artery disease in children. In KD patients, a series of studies has established vascular endothelial cell damage and dysfunction. Endothelial cells' contribution to KD formation and endothelial cells' treatment were systematically described in this review.

Source link: https://doi.org/10.3389/fcvm.2022.981010


Propylthiouracil-Induced Skin Vasculitis.

The authors detail an occurrence of a 61-year-old woman on PTU for one year who was referred to Internal Medicine for a three-month development of painless non-blanching purple patches, non-pruriginous, involving the chest and legs. For the use of small and medium-sized vessels, the autoimmunity revealed ANCA antibody positivity, with a skin biopsy compatible with leukocytoclastic vasculitis/necrotizing vasculitis.

Source link: https://doi.org/10.7759/cureus.27073


Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis.

Consequently, we investigated arterial stiffness and endothelial function in patients with AAV in long-term disease remission and in healthy volunteers in a series of double-blind, randomized case-control forearm plethysmography, and crossover systemic interventional studies. For the comparison, the only result of the case-control research was the difference in endothelium-dependent vasodilation between health and AAV, and the difference in pulse wave velocity between treatment with placebo and selective endothelin-A receptor antagonism. Patients with AAV had 30 percent less endothelium-dependent vaping and 50% reduced acute release of endothelial active tissue plasminogen activator, both of which were relevant in the case-control study. In AAV, both selective endothelin-A/B receptor blockade and dual endothelin-A/B receptor blockade reduced PWV and raised tPA levels in comparison to placebo. Patients with AAV long-term remission have elevated cardiovascular risk, and endothelin-1 plays a role in this.

Source link: https://doi.org/10.1016/j.kint.2022.07.026


Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.

Patients suffering from anti-neutrophil cytoplasmic antibodies -associated vasculitis, as shown by increased cGAMP and increased IFN-I signatures. We created a mouse model for pulmonary AAV that mimics severe disease in patients in order to determine disease mechanisms and potential therapeutic targets. Although recruited monocyte-derived macrophages were the most important disease agents by generating most IFN-u03b2, resident alveolar macrophages contributed to tissue destruction by removing red blood cells and limiting infiltration of IFN-u03b2-producing macrophages. Our research reveals the value of STING/IFN-I axis in encouraging pulmonary AAV formation and identifies cell and molecular targets to improve disease outcomes.

Source link: https://doi.org/10.1084/jem.20220759


Systemic Activation of Neutrophils by Immune Complexes Is Critical to IgA Vasculitis.

polymorphonuclear neutrophil (mediated) injury is often traced to perivascular deposition of IgA1 immune complexes in IgA vasculitis. In IgV patients and controls, serum IgA-IC levels and IgA-IC binding to PMNs were determined. During acute IgA-IC eruptions, we discovered elevated serum levels of IgA-ICs and increased IgA-IC binding to circulating PMNs. This IgA-IC linkable PMNs caused lowering of the threshold for NETosis, resulting in a significant increase in NETs released from PMNs triggered in vitro and PMNs from flares relative to surface IgA-negative PMNs. In tissue sections of IgAV patients, we simulated NETs in close proximity to endothelial cells and IgA-coated PMNs. We were stunned by these in vitro results. During active IgAV primes PMNs and vessel damage, Binding of IgA-ICs raises the risk of ship collision by increased attachment of PMNs to the endothelium and raised NETosis.

Source link: https://doi.org/10.4049/jimmunol.2100924


Livedo Racemosa in Lymphocytic Vasculitis.

This was consistent with the diagnosis of lymphocytic arteritis, a medium vessel vasculitis with no systemic involvement, and generally without systemic involvement. This is linked to livedo reticularis by the presence of larger broken rings that do not change with rising. Liveo racemosa is always pathological, unlike livedo reticularis, which may be physiological. Skin biopsy should take place at the center of the ring in order to determine the feeding artery.

Source link: https://doi.org/10.1093/qjmed/hcac198


Dapsone for Refractory Gastrointestinal Symptoms in Children With Immunoglobulin A Vasculitis.

In this retrospective observational study, we report results in 7 children with IgAV who were treated with dapsone for abdominal pain resistant to CS. In all seven patients, who were tapered off CS without relapse, Dapsone quickly relieved abdominal pain, and then were tapered off CS without relapse. Mild methemoglobinemia and hemolysis appeared to be manageable with planned monitoring and dose adjustment; a single patient who stopped dapsone complained of exhaustion and hypoglobinemia related to methemoglobinemia. In children with IgAV-related gastrointestinal distress, Dapsone may be regarded as a therapeutic alternative for gastrointestinal symptoms refractory to CS.

Source link: https://doi.org/10.1542/peds.2021-055884

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions