Advanced searches left 3/3

Valproic Acid - Wiley Online Library

Summarized by Plex Scholar
Last Updated: 06 September 2022

* If you want to update the article please login/register

Changes in uridine 5′‐diphospho‐glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid

Abstract Valproic acid is well-known as a histone deacetylase inhibitor. HDAC inhibitors have been shown to raise basal and aryl hydrocarbon receptor ligand, enhancing basal and aryl hydrocarbon receptor ligandu2010responsive gene expression, according to a u2010-responsive gene expression. Following VPA treatment of 72 h in Cacou20102 cells, UGT1A6 mRNA was up 7. 9 percent, up 7. 9 percent by 7. 9 fold. In addition, UGT1A6 mRNA was raised by other HDAC inhibitors, indicating that HDAC inhibition led to the UGT1A6 mRNA induction. Following the VPA therapy, AhR and Nrf2 proteins in Caco's nucleus of Cacou20102 cells' nucleus were increased by 1. 5 billion and 1. 7 percent, respectively.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/bdd.2328

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions