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Valproic Acid - Springer Nature

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Last Updated: 06 August 2022

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Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues

Valproic acid is a commonly used antiepileptic drug and a well-known pediatric hepatotoxic agent. The potential of the zebrafish embryo to distinguish between valproic acid and 14 analogues was investigated by offering zebrafish embryos for 120 h post fertilization in the extended version of the fish embryo acute toxic toxicity test, and analyzing liver histology to determine the relationship between liver function and each species's molecular structure. Although histological analysis of zebrafish liver revealed steatosis as the most common adverse response present in human and mice, the resulting structureu2013activity relationship was comparable not only to human HepG2 cells but also to available in vivo mouse and rat data. Thus, there is evidence that zebrafish embryos may be able to bridge the gap between subcellular, cell-based systems and vertebrate models.

Source link: https://doi.org/10.1007/s00204-022-03340-z


Histamine H3 receptor antagonist, ciproxifan, alleviates cognition and synaptic plasticity alterations in a valproic acid-induced animal model of autism

Rationale Autism Spectrum Disorder is a neurodevelopmental disorder characterized by a lack of social interaction and cognitive skills. In the CA1 region of the hippocampus in autistic rats, the aim of the present research was to investigate the effects of the H3R antagonist, ciproxifan, on cognition loss, spatial learning memory, and synaptic plasticity. The effects of the H3R antagonist, ciproxifan, on learning and memory in VPA-exposed rat pups and saline-exposed rat pups using Morris water maze and social interaction tasks were investigated. VPA-exposed rat pups had significantly lower sociability and social memory performance than the saline rats, according to the study. In the VPP-exposed rat pups' MWM task, learning and memory deficits were evident. Our results revealed that CPX 3 mg/kg improved VPA-induced cognitive impairments and FAM 20 mg/kg attenuated cognitive impairments, as well as electrophysiological properties.

Source link: https://doi.org/10.1007/s00213-022-06155-z


Prenatal exposure to valproic acid alters Reelin, NGF expressing neuron architecture and impairs social interaction in their autistic-like phenotype male offspring

During breastfeeding, maternal exposure to the anti-epileptic drug Valproic acid raises the risk of autism spectrum disorders. In this study, we investigated whether prenatal exposure to VPA could influence gene expression, synaptic morphology of nerve growth factor, and Reelin expressing neurons in male offspring's cortex. Rat fetuses were exposed to VPA on 12. 5 gestational days to distinguish in animal models. According to a subsequent analysis, immunohistochemistry revealed that exposure to VPA altered the cytoarchitecture and reduced the dendritic arborization of Reelin, NGF-expressing neurons in cortex.

Source link: https://doi.org/10.1007/s00221-022-06386-8

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions