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Valproic Acid - DOAJ

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Last Updated: 06 October 2022

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Comparative effectiveness of valproic acid in different serum concentrations for maintenance treatment of bipolar disorder: A retrospective cohort study using target trial emulation framework

Summary: Background: There is a lack of agreement on the optimum serum valproic acid concentration for rehabilitation therapy in bipolar disorder. We wanted to investigate the correlation between serum VPA levels and the risk of mood episode recurrence. A meta-analysis involving two research and our cohort found a significantly reduced risk of mood episode recurrence in the 50–u201374 u03bcg/ml group, but not so less so in the 75-u201399 bc/ml group or the 50 u201374 u03bcg/ml group, which did not differ significantly from the one in the 50-u201374 u03bcg/ml group or the u03bc a tu03bcl group a bcl/ml in the rection recg/ml group'u03bcg/ml group or the bcg/ml group ou3bc/ml group or the 50 u03bc/ml group'su03bc/ml group of the 50/ml group or the 50 74 u03bc/ml group or the 50/ml group u03bcg/ml group or the 50 bc/m Interpretation: VPA between 50 and older studies shows that this cohort and previous studies indicate that VPA between 50-u201374-u03bcg/ml may be a more effective way to avoid acute mood episodes in patients with BD undergoing maintenance therapy in patients with BD compared to VPA 50 bcg/ml.

Source link: https://doi.org/10.1016/j.eclinm.2022.101678


The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes

The use of valproic acid during pregnancy has been shown to raise the risk of birth defects and autism spectrum disorder in offspring, according to the scientific studies. As a rodent model of adolescence, the present study investigated the effects of continuous intrauterine exposure to a wide range of VPA on the physical and behavioral response in peripubertal mice as a rodent model of adolescence.

Source link: https://doi.org/10.3389/fnbeh.2022.982811


Valproic acid-associated pancytopenia: A dose-dependent adverse effect

Pancytopenia is a life-threatening disease that is rarely associated with valproic acid. We present a case of an adult female with epilepsy who had been seizure-free for the past three years. She was using a VPA 500 mg bid at the time. The dose of VPA tid had been increased to 500 mg tid. The complete blood cell count was normal one-month later. New episodes of convulsion have appeared after one-year, according to the patient. Valproic acid was also discontinued. Carbamazepine 200 mg tid was first introduced.

Source link: https://doi.org/10.37897/RJN.2019.3.9


Valproic acid restricts mast cell activation by Listeria monocytogenes

The mechanisms of L. m. infection-induced MC activation are well understood, so it is possible to determine whether they are susceptible to attacking and modulation by different drugs. In vivo, new evidence shows that valproic acid inhibits the immune response favoring L. m pathogenesis. We investigated the immunomodulatory effects of VPA on L. m-mediated MC activation herein. We found that VPA inhibited MC degranulation and cytokine release, which was induced by L. m. MC activation during L. m infection depends on Toll-Like Receptor 2 involvement, but no VPA treatment had an effect on MC TLR2 cell surface expression. In addition, VPA was able to reduce MC activation by the classic TLR2 ligands, peptidoglycan, and lipopeptide Pam3CSK4. Following L. m infection, we found that VPA has a role in key cell signaling events that regulate MC activation. These findings show that VPA can modulate the functional activity of various immune cells that participate in the management of L. M disease.

Source link: https://doi.org/10.1038/s41598-022-20054-5


Pharmacokinetic mechanisms underlying clinical cases of valproic acid autoinduction: A review

Although enzyme induction by valproic acid has been documented in several case studies, clinical reports of VPA autoinduction are rare. This review examines findings from published case reports of VPA autoinduction to elucidate plausible mechanisms underlying VPA autoinduction in order to increase clinicians' understanding of VPA autoinduction and management. The following search terms were discovered in a literature analysis: revealed 14 records. The following bibliographic keywords: revealed 14 records. However, only three studies reported clinical cases of VPA autoinduction, with one research paper examining the role of u03b2-oxidation in VPA autoinduction without having a clinical case report. VPA autoinduction in case 1 was predominantly formulation-based, cases 2u20134 were dose-related, and case 5 involved protein displacement reactions with co-prescribed ibuprofen, as shown in Table 1; however, it was not uncommon. However, physicians should consider requesting free fraction along with the total VPA count to diagnose and treat VPA autoinduction, particularly in clinically fragile patients.

Source link: https://doi.org/10.1016/j.jadr.2022.100426


Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile

Valproic acid, a well-established anticonvulsant drug, has been licensed serendipitously and approved for use of epilepsy, migraine, bipolar disorder, and neuropathic pain. Apart from this, VPA has potential therapeutic uses in other central nervous system disorders and in a variety of cancer states. The pharmacology and molecular targets of VPA are briefly discussed in this article. The article follows further discusses the chemical changes in VPA, including amide-derivatives, acid and cyclic analogues, urea derivatives, and pro-drugs, comparing their pharmacological appearance to that of the parent molecule. The new challenges for the clinical use of these derivatives are also addressed.

Source link: https://doi.org/10.3390/molecules27010104


Neuroprotective Effect of Valproic Acid on Salicylate-Induced Tinnitus

In humans and animals, a temporary hearing loss can be accompanied by high-dose salicylate, and the appearance of a high-pitched tinnitus. High doses of salicylate elevate N-methyl-d -aspartate receptor levels, resulting in a rise in Ca 2+ influx and the induction of excitotoxicity. Valproic acid is widely used for the treatment of bipolar disorder, epilepsy, and migraine headaches, and is known to limit NMDA receptor function. In vitro and in vivo, we investigated the beneficial effects of VPA in a salicylate-induced tinnitus model. The expression of NMDA receptor subunit NR2B, phosphorylated cAMP response element-binding protein that is not present in U2014, was determined by various biochemical methods. These results, together, show that the beneficial effects of VPA in a salicylate-induced temporary hearing loss and tinnitus model.

Source link: https://doi.org/10.3390/ijms23010023


The Effect of Ceftriaxone in Valproic Acid-Induced Mouse Model ofAutism

Methods: We wanted to investigate the effects of different doses of ceftriaxone in the postnatal period in male mice exposed to valproic acid at 12. 5 days of pregnancy. Methods: We divided them into 12 groups in our study. On days 54 and 55, all groups were tested on the three chamber sociability and social interaction questionnaire as well as the Rota rod test. Our findings indicate that ceftriaxone did not have no therapeutic effect on autism-induced autism's chronic onset of autism.

Source link: https://doi.org/10.34172/apb.2022.086

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions