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Valproic Acid - Crossref

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Last Updated: 06 October 2022

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Valproic acid as a radiosensitiser in glioma: A systematic review and meta-analysis

Abstract Background Histone deacetylase inhibitors, such as valproic acid, have the ability to increase radiotherapy safety and minimize treatment adverse events via epigenetic modification and radiosensitization of neoplastic cells. Methods A systematic review looked through electronic searches of MEDLINE, Embase, The Cochrane Library, and the International Clinical Trials Registry Platform to find studies examining the effectiveness and AEs of HDACi therapy in solid organ malignancy patients undergoing RT. Results In RT-treated solid organ malignancy patients, ten studies investigating the efficacy and/or AEs of HDACi met inclusion criteria. HDACi valproic acid in high-grade glioma patients, of which nine studies assessed OS and five studies looked at AEs, among which nine studies evaluated OS and five studies examined AEs. Conclusion This research shows that glioma patients undergoing RT may have prolonged life as a result of the HDACi VPA administration. In addition, more research into the use of HDACi radioadjuvant therapy in non-glioma solid organ malignancies is warranted.

Source link: https://doi.org/10.1093/nop/npac078


Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues

Abstract Valproic acid is a commonly used antiepileptic drug and a well-known pediatric hepatotoxic agent. To this end, the potential of the zebrafish embryo to distinguish between valproic acid and 14 analogues was investigated by exposing zebrafish embryos for 120 h post fertilization in the fish embryo acute toxicity test, as well as analyzing liver histology to determine the correlation between liver function and each compound's molecular structure. The morpho-activity relationship derived was similar to human HepG2 cells, but also to animal and rat data, according to histological review of zebrafish liver did not identify steatosis as the most common adverse effect in human and mice. In short, there is evidence that zebrafish embryos could be a tool to bridge the gap between subcellular, cell-based methods, and vertebrate models.

Source link: https://doi.org/10.1007/s00204-022-03340-z


The influence of continuous prenatal exposure to valproic acid on physical, nociceptive, emotional and psychomotor responses during adolescence in mice: Dose-related effects within sexes

The use of valproic acid during pregnancy has been shown to raise the risk of birth defects and autism spectrum disorder in children. As a rodent model of adolescence, the present study investigated the effects of continuous intrauterine exposure to a wide variety of VPA on the physical and behavioral responses in peripubertal mice as a rodent model of adolescence.

Source link: https://doi.org/10.3389/fnbeh.2022.982811


Use of Valproic Acid for the Management of Delirium and Agitation in the Intensive Care Unit

Objective: Compare the use of other antipsychotics to the use of valproic acid for delirium and agitation in the intensive care unit. Patients were eligible if they had a Richmond Agitation-Sedation Scale u22652 and Confusion Assessment Method for the ICU positive. Results: One hundred eight patients were enrolled, 49 patients in the VPA group, 49 patients in the VPA group, and 59 patients in the control group were included. Conclusions: Our results show that VPA is associated with similar delirium and agitation-free days compared to other non-VPA drugs, with some adverse effects.

Source link: https://doi.org/10.1177/08971900221128636


Pharmacological modulation of cell functional activity with valproic acid and erythropoietin

Valproic acid is a carboxylic acid with a branched chain that is used as an antiepileptic agent. In vitro, it has been shown that valproic acid reduces the intracellular level of oxygen active forms. The cell cycle arrest, differentiation induction, and tumor cell growth inhibition are all ways that can contribute to tumor formation. Conclusion : The effect of VA and EPO on cells can be used in cell technologies.

Source link: https://doi.org/10.3897/rrpharmacology.5.34710


Impairment in social interaction and hippocampal long-term potentiation at perforant pathway-dentate gyrus synapses in a prenatal valproic acid-induced rat model of autism

Abstract (abstract) It has been well established that prenatal valproic acid exposure in rats leads to autism-like behaviours and social inadequates. However, there are concerns over the effect of in utero valproic acid exposure on long-term potentiation. This paper looked at the relationship between infant pathway-dentate gyrus synapses in male offspring of a rat model of autism caused by prenatal exposure to valproic acid. In control rats, the birth weight in valproic acid-exposed rats was significantly lower than in control rats. Long-term potentiation was hampered by valproic acid exposure, which hindered dentate gyrus synapses' ability to induce long-term potentiation. It is widely believed that the hippocampus plays a key role in learning and memory, as well as social interaction and social memory. Hence, hippocampal synaptic plasticity deficiencies may be responsible, at least in part, for the social interaction in valproic acid-exposed rats.

Source link: https://doi.org/10.1093/braincomms/fcac221


Valproic Acid as Adjuvant Treatment for Convulsive Status Epilepticus: a Randomised Clinical Trial

Patients with de novo established GCSE were analyzed to see if valproic acid as complementary therapy to the stepwise approach improves the outcomes of patients with de novo established GCSE. Methods This was a multicentre, double-blind, placebo controlled trial in 244 adults admitted to intensive care units for GCSE in 16 French hospitals between 2013 and 2018. Intervention patients received a 30 mg/kg VPA loading dose, followed by a 1mg/h 12h infusion, while the placebo group received an identical intravenous delivery of 0. 9% saline as a bolus and continuing infusion. Patients were discharged from hospital by day 15. The primary outcome was a proportion of patients discharged from hospital by the day 15. patients hospitalized on day 15 [VPA, 77 versus placebo, 72 versus placebo, 72 percent confidence interval; p = 0. 58] There was no between-group difference for patients hospitalized at day 15 [Japan's adjusted relative risk 1. 04; 95% confidence interval; p = 0. 58]. Conclusions VPA's updated adult GCSE treatment is well accepted, but it did not increase the number of patients hospitalized by day 15.

Source link: https://doi.org/10.21203/rs.3.rs-2070140/v1


Valproic acid restricts mast cell activation by Listeria monocytogenes

The L. m. infection's cellular pathways are well documented, so it is possible to determine whether they are vulnerable to targeting and modulation by various drugs. In vivo, new evidence indicates that valproic acid reduces the immune response that favors L. M pathogenesis. Herein, we investigated the immunomodulatory effect of VPA on L. m. -mediated MC activation. MC activation during L. m. infection depends on Toll-Like Receptor 2 involvement, but no VPA treatment appeared to have an effect on MC TLR2 cell surface expression. VPA reduced the initiation of critical events on MC signaling cascades, including the rise in intracellular Ca 2+ and phosphorylation of p38, ERK1/2, and -p65 subunits of NF-u03baB, as shown by the increase on intracellular Ca 2+ and phosphorylation of p38, ERK1/2, and -p65 subunits, NF-u03baB's Following L. m. infection, our results show that VPA has an effect on key cell signaling pathways that regulate MC activation. These results show that VPA can influence the functional activity of various immune cells that control L. m disease.

Source link: https://doi.org/10.1038/s41598-022-20054-5


Enhanced antitumor activity of combined methotrexate and histone deacetylase inhibitor valproic acid on mammary cancer in vitro and in vivo

In vitro and in vivo, the present research sought to determine the inhibitory role of VPA on mammary cancer cells' viability and its enhancing effect with methotrexate. When VPA was combined with MTX in vivo, it dramatically hampered Ehrlich ascites carcinoma and solid Ehrlich tumor mouse models, as well as tumor inhibition. All these results suggest that the combination of MTX and VPA may have clinical and adjuvant therapeutic use in mammary cancer treatment.

Source link: https://doi.org/10.1139/cjpp-2021-0799

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions