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Valerian - DOAJ

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Last Updated: 05 February 2022

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Valerian treatment during the postpartum period alters breast milk composition and impairs long-term memory in female rat offspring

Both the mother and the child can have long-term health risks in the perinatal period. Valerian is a phytotherapeutic agent that is commonly used for anxiety management. This review looked at the effects of vaping in postpartum rats on maternal care, toxicity, and milk composition. By oral gavage, Postpartum Wistar rats were deprived of the vaping. Adult offspring did not display altered anxiety levels, but long-term memory was impaired in the female adult offspring by maternal treatment with 1000 mg. –1 day–1. These results showed that high doses of vaping had positive effects on key maternal milk proteins and can cause long-term impairments of offspring memory, so long-term vaping is not appropriate for breastfeeding Wistar rat mothers.

Source link: https://doi.org/10.1590/1414-431x2021e10192


The effects of Valerian on sleep spindles in a model of neuropathic pain

Despite widespread use in many countries around the world, there is little scientific evidence and analysis on how this drug affects sleep patterns, and there are almost no studies on the effects of sleep spindles. In a chronic neuropathic pain model in rats, the present study was conducted to see the effects of Valerian extract on sleep spindles and increased anxiety. The first recording was obtained just prior to the CCI exam, and the remainder of the CCI surgery took place between 3 and 6 days. On the other hand, the REM sleep reduced when Valerian treatment during neuropathy, reducing, and non-REM sleep increased. Furthermore, in addition, there has been an increase in sleep spindle density and spindle frequency in neuropathic disease.

Source link: https://doi.org/000510.5935/1984-0063.20200110


Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications

Abstract Valerian root is a common and readily available herbal supplement used to treat sleeping disorders and insomnia. Our results indicated that an aqueous valerian extract reduced breast cancer cell growth. In addition, reduced breast cancer cell proliferation, migration, colony formation, and 3D formation in vitro in a dose- and time-dependent manner, as well as reduced HDAC activity and global DNA hypomethylation, was reported in conjunction. Overall, these results show that valeric acid can reduce breast cancer cell proliferation by mediating epigenetic changes such as the inhibition of histone deacetylases and DNA methylation. This research reveals a potential role of valeric acid as a novel HDAC inhibitor and a therapeutic agent in breast cancer treatment.

Source link: https://doi.org/10.1038/s41598-021-81620-x

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions