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Uterine fibroid - DOAJ

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Last Updated: 07 May 2022

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Ginsenoside Rb1 inhibits proliferation and promotes apoptosis by regulating HMGB1 in uterine fibroid cells

The inhibitory and apoptosis rate of uterine fibroid cells treated with Rb1 was significantly up-regulated, compared to untreated fibroid cells, while the expression level of HMGB1 was significantly down-regulated. Overexpression of HMGB1 in uterine fibroid cells reversed the inhibitory effect on proliferation and the promotion of apoptosis of Rb1 in uterine fibroid cells. paraphrased cells proliferation could be inhibited by Ginsenoside Rb1 and promote apoptosis.

Source link: https://doi.org/10.1080/21691401.2019.1643732


Prolonged Cadmium Exposure Alters Migration Dynamics and Increases Heterogeneity of Human Uterine Fibroid Cells—Insights from Time Lapse Analysis

Cadmium is one of the most common environmental heavy metal contaminants, and is classified as an endocrine disruptor and carcinogen. Blood Cd levels are related to fibroid tumor size in women with uterine fibroids. We performed time lapse imaging using a Zeiss confocal microscope and analyzed results by Imaris and RStudio to determine the morphological and mechanodynamic characteristics of uterine fibroid cells exposed to prolonged Cd exposure. According to a quantitative review, prolonged Cd exposure significantly modified cell migration behaviour, including increased track length and reduced track straightness. The heterogeneity in nuclear size has also greatly increased the heterogeneity in nuclear size, which has been significantly enhanced. DNA profiling by NanoString analysis and Ingenuity Pathway Analysis & Ingenuity Pathway Analysis both found that gene expression changes as a result of Cd exposure enhanced cell migration and invasion.

Source link: https://doi.org/10.3390/biomedicines10040917


Application of cone-beam computed tomography angiography in a uterine fibroid embolization procedure: A case report

Incomplete infarction of the fibroid due to intermittent vascular supply to the fibroid, which was not identified by the operator, one of the principal causes of failure in uterine fibroid embolization procedures is incomplete infarction of the fibroid. The right ovarian artery was discovered to have a variant vascular supply to the fibroid, which was revealed to be originating from the right ovarian artery.

Source link: https://doi.org/10.1016/j.radcr.2017.09.027


Study on the correlation of MLCK and FAP expression with uterine fibroid cell proliferation and invasion

The aim: To investigate the relationship between myosin light chain kinase and fibroblast activation protein expression with uterine fibroid cell proliferation and invasion. mRNA and FAP protein expression in uterine fibroids samples were significantly higher than those in normal uterine muscle samples, and Survivin, Livin, Bcl-2, Snail, N-cadherin, and MMP2 protein expression in uterine fibroids samples with elevated MLCK and FAP were significantly higher than those in normal uterine muscle tissue samples; Results: MLCK and FAP mRNA expression in uterine fibroids samples were significantly higher than those in mRNA expression in mRNA expression in mRNA samples were significantly higher than those in mRNA samples mRNA samples; mRNA mRNA, Bcl-2, N-cadherin, N-cadhe mRNA mRNA, N-cadhe mRNA samples with elevated mRNA expression in mRNA samples with elevated mRNA.

Source link: https://doaj.org/article/d63b9323454246a080cae5042fd5baa9


Broad ligament uterine fibroid: Management with Davinci robotic myomectomy

It's well known that myomectomy of a large broad ligament fibroid is a challenge to the surgeon, especially because of persistent bleeding and ureteric injury, as well as later complications such as pelvic hematoma and pneumonia. Case description: A 40-year-old nulliparous white female was diagnosed with dysmenorrhea, menorrhagia, pelvi-abdominal mass, and primary infertility in a 40-year-old white female. According to a Doppler flow report, the greater fibroid is broad ligament in nature with minimal vascularity between the broad ligament fibroid and the uterus. An intramural subserous fibroid was first removed, followed by a large broad ligament fibroid, and the anterior leaf of the broad ligament was sutured. Conclusion: This case was designed to show that robotic assisted laparoscopic myomectomy is safe and effective in patients with a large broad ligament fibroid who want to preserve their reproductive ability.

Source link: https://doi.org/10.1016/j.mefs.2015.03.003


Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo

With in vitro and in vitro techniques, we wanted to explore the effects of RSV on UF. Tumors were implanted in mouse xenograft models by subcutaneous injection of Eker rat-derived uterine leiomyoma cells transfected with luciferase in five-week-old female nude mice, with luciferase. Primary human leiomyoma cells were also used in vitro experiments. RSV significantly reduced the percentage of cells showing expression of proliferating cell nuclear antigen and -smooth muscle actin in vivo and reduced the number of cells displaying the expression of proliferating cell nuclear antigen and -smooth muscle actin, which is notably reduced in vivo tumor formation. In addition, lowering the amounts of -catenin protein, RSV reduced leiomyoma cell viability, reduced leiomyoma cell viability, reduced leiomyoma cell viability, and reduced the mRNA levels of collagen type 1 and -SMA. Our results demonstrated the inhibitory effects of RSV on the ELT-3-LUC xenograft model and indicated that RSV reduced ECM-related protein expression in primary human leiomyoma cells, indicating its potential as an anti-fibrotic therapy for UF.

Source link: https://doi.org/10.3390/antiox8040099


The outcome of magnetic resonance-guided high-intensity ultrasound for clinically symptomatic submucosal uterine fibroid performed accidentally in very early pregnancy: a case report

This is a review of unintended use of MR-HIFU therapy of uterine fibroids in a woman in early pregnancy that should be treated as the first mention of such an occurrence. To reduce UF-related symptoms, a 37-year-old nullipara with confirmed UFs, excessive uterine bleeding, and dysmenorrhea, was ideally suited for MR-HIFU therapy. Basing on early pregnancy ultrasound it was estimated that at the time of MR-HIFU surgery, the patient was about ten days after the birth. After the therapy and pregnancy, symptoms of UFs have significantly decreased. Despite the fact that the pregnancy being exposed to MR-HIFU treatment had escalated, the uncomplicated course, the present case shows that counseling/management in women of reproductive age should be standardized to minimize potential risks of such unrecommended procedures for the fetus. According to current guidelines, MR-HIFU procedures to treat UFs should never be carried out without a negative pregnancy test.

Source link: https://doi.org/10.1080/02656736.2019.1660002


Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study

For this cross-sectional research, 154 premenopausal women were tested to see if low serum Vit D3 levels correlate with elevated risk of UFs. Methods. Within the case group, a statistically significant inverse correlation was also observed between serum 25-vit D levels and total UF volume. Subjects with higher fibroid volumes had lower serum Vit D levels and vice versa. A statistically significant inverse correlation between serum 25-vit D levels and total fibroid volume in black subjects was found in a statistically significant inverse relationship. In white subjects, an inverse correlation was also present, but it was not statistically significant. Conclusion: Lower serum Vit D levels were also related to UF burden in various ethnic groups, but not to a point of significance. Vitamin D deficiency, race/ethnicity, risk factor, premenopausal women, is a possible risk factor for UFs. Key words: vitamin D deficiency, epigonogenesis, risk factor, and pregnancy hormones are all typical risk factors for UFs.

Source link: https://doaj.org/article/be16ad444f2649eab23432cfd1804a08


Superior hypogastric nerve block (SHNB) for pain control after uterine fibroid embolization (UFE): technique and troubleshooting

Abstract Background After Uterine Fibroid Embolization, superior hypogastric nerve Block was shown to be an effective pain management tool, reducing the need for opiates and allowing same-day discharge after UFE. Initially embolization was blocked, but the Superior hypogastric nerve Block was the part of the abdominopelvic sympathetic nervous system that provides a targeted approach to pelvic organs and a target for an anterior approach Superior Hypogastric nerve Block After embolization. Patient positioning for the block, image guidance, and needle positioning, as well as the choice and method of anesthetic injection are all part of a step by step technological approach to SHNB. Superior Hypogastric nerve Block can be a valuable tool in the Interventional armamentarium to ensure that UFE patients with fibroids have a happier experience while still facilitating same-day discharge, as well as facilitating same-day discharge.

Source link: https://doi.org/10.1186/s42155-020-00141-2


Validation of a menstrual pictogram and a daily bleeding diary for assessment of uterine fibroid treatment efficacy in clinical studies

When test reliability was defined by the AH method and Patient Global Impression of Severity scores, acceptable intraclass correlation coefficients were used to ensure stability. Strong and moderate-to-strong correlations with menstrual blood loss as measured by the AH method showed clear and moderate to high correlations. Increasing disease severity, as shown by the AH method and PGI-S. SAP-c v3 and UF-DBD, as well as good cooperation with the AH method, showed a reduced rate of missing patient data relative to the AH method and PGI-S. Conclusions This research backs up the use of the MP SAP-c v3 and UF-DBD to measure clinical sensitivity endpoints in UF phase III studies, which were largely based on the AH method.

Source link: https://doi.org/10.1186/s41687-020-00263-0

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions