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Background: : Urogenine fibroid or leiomyomas are the most common benign uterine tumors, and can be seen in up to 40% of women in reproductive age. Objective : Objective [UAE]: A well-known alternative to surgical and medical therapy for symptomatic fibroids is a uterine artery embolization [UAE] is an accepted alternative to surgical and medical intervention for symptomatic fibroids with reference to fibroid volume reduction as determined by ultrasound. Embolization of bilateral uterine arteries was carried out with gelfoam and Polyvinylachalcohol spheres at 1,3,6 and 12 months, according to a publication by ultrasound. Results: In 26,molar pregnancy in 2,retained products in 2, adenomyosis and arteriovenous malformation in one patient revealed fibroids in 26,molar pregnancy in 26, million patients during preoperative ultrasounds. The mean decrease in fibroids preoperative volume was statistically significant at 1,3,6 and 8 months. Of the 26 patients with fibroids pre-treatment mean fibroid volume was 253cm.
Source link: https://doi.org/10.36106/paripex/3707490
Objectives: The aim of this investigation was to determine if a long versus short time between preoperative uterine artery embolization and subsequent myomectomy has an effect on perioperative blood loss and complication rate in cases of elevated multi-fibroid uterus. Participants and Methods: PUAE was administered 24 hrs before the operation in 21 patients between January 2011 and March 2016, or 19 days before the surgery in 23 patients from March 2016 to May 2018. In none of the PUAE patients, conversion to hysterectomy was not required, but it was absolutely necessary in one of the control patients. In group 1's comparison, there was a significant reduced risk of high blood loss in group 1 and a smaller but not significantly lower risk of group 2 without an embolization preoperatively. Also, a significant reduced risk of postoperative blood transfusion for groups 1 and 2 was seen relative to group 3 in comparison to group 3. In group 2 compared to group 3, the risk of postoperative complication risk was lower than in group 3. A decrease in the control group's symptoms was found in the context of the postoperative questionnaire, affecting ten of 11 patients in group 1, 12 of 12 patients in group 2, and 31 of 36 patients from the control group reported an improvement of their complaints. Compared to no intervention before myoma enucleation, a significant decrease in high blood loss, the need for postoperative blood transfusion, and postoperative complications in patients with severe fibroid disease have been reduced following PUAE.
Source link: https://doi.org/10.1159/000521914
This study was intended to establish a 100% sensitivity testing uterine sarcoma using MRI and serum LDH levels. All sarcomas were found in the sample with high T2WI and either high T1WI, fuzzy margin, or high LDH values, according to the MRI images and LDH values of 1801 cases of uterine sarcoma and uterine fibroid. Among the 36 sarcoma cases, the group with positive T2WI, T1WI, margin, and serum LDH levels had a poor prognosis.
Source link: https://doi.org/10.21203/rs.3.rs-1085919/v1
Cadmium is one of the most common environmental heavy metal contaminants, and is classified as an endocrine disruptor and carcinogen. There is a correlation between blood Cd levels and fibroid tumor size in women with uterine fibroids. Fibroid cells were exposed to ten million CdCl2 for six months, and a fast-growing Cd-Resistant Leiomyoma culture, referred to as CR-LM6, was discovered in this research. We conducted time lapse imaging using a Zeiss confocal microscope and analysed results by Imaris and RStudio to determine the morphological and mechanodynamic characteristics of uterine fibroid cells cultured with prolonged Cd exposure. According to updated quantitative review, prolonged Cd exposure has significantly improved cell migration characteristics, such as increased track length and reduced track straightness. According to NanoString's report and Ingenuity Pathway Analysis, the direction of gene expression changes as a result of increased cell movement and invasion as a result of Cd exposure.
Source link: https://doi.org/10.3390/biomedicines10040917
The surgical approach in an intraoperative finding of previously undiagnosed tumor lesions must be changed, since it will adversely influence surgical results. Gastrointestinal stromal tumors are the most common tumors of the gastrointestinal tract that arise from the mesenchymal anlage. The article discusses a clinical case of a patient with multiple uterine fibroids and in whom a substantial GIST of the sigmoid colon was discovered intraoperatively that had been previously mistook for one of the subserous nodes of uterine fibroids.
Source link: https://doi.org/10.17816/pavlovj71656
Uterine fibroid is the most common pelvic tumor in women during their reproductive years. A 43-year-old woman with abnormal vaginal bleeding and dysmenorrhea was identified as the candidate for myomectomy. In this case, dry cupping therapy can be more effective and safe in reducing fibroid-related signs like dysmenorrhea and excess bleeding, as well as the size of fibroid. However, further clinical research is required to establish the effectiveness and safety of dry cupping therapy for the treatment of uterine fibroids.
Source link: https://doi.org/10.18502/tim.v5i2.3629
Background: Uterine fibroids is the most common cancer in women's reproductive age group. uterine fibroids have been found to be more prevalent in patients with hypertension, another condition with a predilection for the black race. The study compares angiotensin II serum levels in women with uterine fibroids and women without uterine fibroids. The study was a prospective case-controlled research involving ninety consecutive women with a confirmed diagnosis of uterine fibroids and ninety consecutive women with a normal uterus with no medical evidence matching for age, parity, and body mass index. Conclusions: The mean serum level of angiotensin II in women with uterine fibroids was much higher than that in women with no uterine fibroids, according to p 0. 001. According to p= 0. 01, women with uterine fibroids were about six times more likely to have hypertension than women without fibroids.
Source link: https://doi.org/10.47363/jgrrr/2022(4)149
During the bleeding and fibroid outbreak, 90 people from the consultant outpatient clinic for menorrhagia and fibroid were scheduled in two groups, the first group was given 3. 2 mg goserelin acetate subcutaneously monthly for three months, and the second group received 3. 2 mg noerelin acetate subcutaneously monthly, with cyclically if no bleeding for three months. In the nothoriotone group, the haemoglobin level was 9. 28 gm/100ml 2. 44 pre-treatment and 11. 2 gm/100ml 2. 46, respectively. If surgery is postponed for medical or other reasons, Goserelin demonstrated improved patient response and reduced in the tumor size in patients with menorrhagia and uterine fibroids.
Source link: https://doi.org/10.31351/vol19iss2pp54-58
The authors recommend that women carrying a large uterine fibroid be well-observed during the postpartum period to determine an imminent uterine fibroid vaginal prolapse early, to prevent fibroid vaginal prolapse early, obstructive disorders, and postpartum hemorrhage as well.
Source link: https://doi.org/10.31254/jmr.2016.2203
Purpose: To investigate the in vivo anti-tumor effect of piperlongine in a mouse model of leiomyoma xenograft and in leiomyoma cell lines. Methods: Using MTT assay, the anti-proliferative effect of PL on ELT-3 cells was established. In vitro experiments were carried out using human and rat leiomyoma cells. In vivo experiments, immunodeficient mice were subcutaneously administered with varying amounts of estrogen or progesterone, and xenografted with explanting human leiomyomyoma cells. Piperlongumine PL exhibited a significant and dose-dependent increase in caspase-3 function, apoptosis, and cell proliferation inhibition, as shown by p 0. 01. In addition, Western blot results showed that PL reduced the phosphorylation of the Akt signaling pathway. p 0. 02. According to immuno-histochemical tests, PL reduced the expression of proliferation marker in xenografted tumor tissues, p 0. 02.
Source link: https://doi.org/10.4314/tjpr.v20i7.16
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