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Uterine Cancer - Crossref

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Last Updated: 07 June 2022

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Screening for uterine cancer.

"Historically, endometrial cancer is expected to appear at an early age without disseminated disease. " Endometrial cancer in certain populations appears at a late stage and has a mortality risk similar or even higher than that of ovarian cancer. In the current era of the disease, it is now time to revisit the debate on endometrial cancer screening in the modern age. Methods: We analyzed the most common risk factors associated with endometrial cancer in order to create a risk assessment nomogram using nationally available datasets. We bootstrapped our risk calculations to exclude results from the most recent year's most recent year and used those cases as our validation set to determine the likelihood of endometrial cancer in those patients with known disease. The results: The correlation with the candidate variables was as expected for each learning data set. About 6x and 15:1, respectively, were the incidence rate ratios of cancer in the presence of known risk factors already present in the population EMR. Conclusions: Our nomogram was able to accurately predict the presence of cancer in patients from both national databases and the local safety net hospital community. With these encouraging retrospective findings, we'll continue to use our risk assessment technique in the clinical setting to forecast asymptomatic endometrial disease in at-risk patients, choosing those for further clinical study, including triage, ordering ultrasound, or even conducting endometrial sampling using shared decision making. ".

Source link: https://doi.org/10.1200/jco.2022.40.16_suppl.e18578


Cancer-associated fibroblasts in uterine corpus endometrial carcinoma.

"e17618 BACKGROUND: In Uterine Corpus Endometrial Carcinoma, the exact role of cancer-associated fibroblasts and their invasive characteristics are unclear. CAFs are a vital component of the tumor microenvironment and promote tumorigenesis and cancer aggressiveness. With u201chighu201d, u201d, and u201d, the data of CAF scores in each cohort were divided into quarters, we sorted the population by upper quartile and lower quartile, as well as u201d, and u201d, we'd rank. At least two methods were applied to the consensual low CAF group, with samples labeled with u201clowu201d by at least two methods. The GSEA findings showed substantial gene expression differences between the high and low CAF groups, showing significant gene expression differences between the high and low CAF groups. Gene sets were significantly enhanced at nominal p value 0. 01 in the low group, while 869 gene sets were significantly enriched at nominal p value 0. 01 in the high group, with nominal p value significantly elevated at nominal p value 0. 01 in the low group. CAFs were found to be linked to an immune-suppressive microenvironment, according to our report.

Source link: https://doi.org/10.1200/jco.2022.40.16_suppl.e17618


Interaction of race and socioeconomic status as risk modulators of treatment delay and cancer-specific mortality in uterine cancer.

"5595 Background: The bulk of studies into uterine cancer study include both high and low-grade histologies, but do not include a large population of patients. In several studies, race is viewed as a biological construct, but it may be more effective thought of as a predictor of socioeconomic injustice and deprivation. Women with uterine cancer may have a significant role in the disease course. We included non-Hispanic Black and White women diagnosed with uterine cancer between 2010 and 2018. To determine the risk of uterine cancer specific mortality and to assess statistical correlation between race and Yost score, competing risk analysis was used to determine risk of uterine cancer-specific mortality and to assess statistical correlations between race and Yost score. In comparison to NHW and NHB women in the lowest Yost quintiles, Race and Yost score combined to raise the risk of cancer-specific mortality in NHB women in the lowest Yost quintiles relative to NHW and NHB women in the highest quintiles. The relationship between race and Yost result remained only among women with low grade cancers. As Yost's score decreased, time from diagnosis to surgery soared. Women in the lowest Yost quintile had a decreased risk of getting surgery within six weeks of diagnosis. In women with high grade cancers, there was no correlation between race, Yost score, and delays in time to surgery. Conclusions: The race and Yost score, an area-based measure of socioeconomic deprivation, has been correlated with an elevated risk of cancer-specific mortality among women with low grade cancer. The association of race and socioeconomic deprivation may explain persistent uterine cancer survival, especially in low grade disease, where prompt curative surgery is the most feasible option.

Source link: https://doi.org/10.1200/jco.2022.40.16_suppl.5595


Early cervical cancer and recurrence after minimally invasive surgery without uterine manipulator

"Abstract Objective: Global cervical cancer is the fourth most common cancer, and it is also the fourth leading cause of death among women after breast cancer, colorectal cancer, and lung cancer. The aim of this research is to investigate the long-term oncological efficiency of laparoscopic therapy without the use of a uterine manipulator for patients with early-stage cervical cancer patients. According to the FIGO classification, nineteen patients had an early-stage cervical cancer, including two cases of cervical cancer stage IA2, ten cases of cervical cancer stage IB1, and seven cases of cervical cancer stage IB2 were among the thirty-one patients enrolled. Conclusion: After five years of follow-up, recurrence rates in patients treated with minimally invasive surgery are about 10%, but the use of uterine manipulators is not related to a higher rate of recurrence rates.

Source link: https://doi.org/10.21203/rs.3.rs-1633686/v1


Identification of Exon-Deleted Progesterone Receptor mRNAs in Human Uterine Endometrial Cancers

In all samples reviewed, the exon 4-deleted, exon 6-deleted, exon 6,4-deleted, and exon 3,4-deleted PR variant mRNAs were not detected, particularly in poorly differentiated adenocarcinoma, as compared to well-differentiated and moderately distinct adenocarcinomas. As endometrial cancer cells differentiate, endometrial cancer cells undergo dedifferentiation, these translated variant proteins may contain functional diversity and may alter the progestational response of wild-type PR, as well as lose the expression of some PR variant mRNAs.

Source link: https://doi.org/10.1159/000012080


Increased Serum Concentrations of Soluble Vascular Cell Adhesion Molecule-1 in Uterine Cervical Cancer

"The aim of this investigation was to determine the serum concentration of soluble vascular cell adhesion molecule-1 in women with squamous cell carcinoma of the cervix. " According to the researchers, the patients with cervical cancer in stages 0–u2013IV, and those with recurrent tumors were 1,353. 0 ng/ml, respectively.

Source link: https://doi.org/10.1159/000009982


Changing Incidence of Uterine Cancer in Rural Egypt: Possible Impact of Nutritional and Epidemiologic Transitions

"PURPOSE Uterine cancer is a top-ranking women's cancer worldwide, with widespread prevalence variations across countries and urban areas. " Hormonal exposures and access to health care in rural and urban areas around the world vary between rural and urban areas. Egypt has an overall low incidence of uterine cancer, but urban and urban lifestyles have varies. Is there an increase in the incidence of uterine cancer in rural and urban areas of middle-income countries such as Egypt? The aim of this research was to investigate the differences in uterine cancer's clinical and socioeconomic characteristics from 1999 to 2010 in rural and urban Gharbiah provinces, Egypt. METHODS data for all 660 patients with uterine cancer enrolled in the Gharbiah Population-based Cancer Registry were abstracted. In urban areas, the age standardized IR was 2. 5 times higher than in rural areas. The IR in urban areas was 2. 46 times higher than in rural areas, according to the rate ratio. CONCLUSION This report revealed that the disease IR in rural areas has increased in the last decade in the last decade but that it is still low compared to the prevalence in urban areas in Egypt, which did not show a significant rise in incidence. The prevalence of uterine cancer in urban areas in Gharbiah is almost identical to global averages. Future studies will investigate the etiologic reasons contributing to rural unemployment rises and quantify the change in rural case finding," the researcher says.

Source link: https://doi.org/10.1200/jgo.18.00255


Association Between Power Morcellation and Mortality in Women With Unexpected Uterine Cancer Undergoing Hysterectomy or Myomectomy

"In this research, we investigated whether continuous power morcellation at the time of hysterectomy or myomectomy is related to increased mortality risk in women with occult uterine cancer. " METHODS In New York, we found 843 women with occult endometrial carcinoma and 334 women with occult uterine sarcoma who underwent a hysterectomy or myomectomy for presumed benign signs from October 1, 2003 to December 31, 2013. RESULTS LSH/LM, a symptom of disease-specific mortality in women with occult uterine sarcoma, was a greater risk of disease-specific mortality than TAH. LSH/LM, a subset of leiomyosarcoma, was a factor in disease-specific mortality in comparison to supracervical abdominal hysterectomy and TAH. CONCLUSION "Uncontained power morcellation has been correlated with elevated mortality risk in women with occult uterine sarcoma, particularly in those with occult leiomyosarcoma. ".

Source link: https://doi.org/10.1200/jco.19.00562


Hysterectomy-Corrected Uterine Corpus Cancer Incidence Trends and Differences in Relative Survival Reveal Racial Disparities and Rising Rates of Nonendometrioid Cancers

"PURPOSE Uterine corpus cancer incidence rates are expected to increase, according to a statistic often attributed to the obesity epidemic. METHODS We calculated the hysterectomy risk from the Behavioral Risk Factor Surveillance System, which was estimated by the METHODS. RESULTS Hysterectomy-corrected incidence rates of uterine corpus cancer were similar among non-Hispanic whites and blacks, as well as lower among Hispanics and Pacific Islanders. In non-Hispanic whites, Endometrioid carcinoma incidences were among the highest in non-Hispanic whites, although nonendometrioid carcinoma and sarcoma rates were the highest in non-Hispanic blacks. The incidence of uterine corpus cancer risk in non-Hispanic whites, Hispanics, and Asians/Pacific Islanders from 2000 to 2015 soared among non-Hispanic whites, Hispanics, and Asians/Pacific Islanders from 2003 to 2015. Overall incidence rates among non-Hispanic blacks in 2007 exceeded those of non-Hispanic whites. Endometrioid carcinoma rates in non-Hispanic blacks, Hispanics, and Asians/Pacific Islanders increased among non-Hispanic whites, Hispanics, and Asians/Pacific Islanders, but non-Hispanic whites remained stable among non-Hispanic whites; however, non-Hispanic whites' non-Hispanic whites increased strongly among non-Hispanic whites; however, non-Hispanic whites, s, among non-Hispanic whites chym's, Hispanic blacks, and Asians, Pacific Islanders, &Pacific islanders, and Pacific Islanders, and Pacific Islanders, and Asians, and Pacific Islanders, and Pacific Islanders, Asian/Pacific whites; however, Pacific Islanders; however, non-Hispanic whites; nevertheless, non-Hispanic whites; endoid carcinoma risks & however, non-Hispanic whites; non-Hispanic whites; nevertheless, non-Hispacial whites, non-Hispanic whites;.

Source link: https://doi.org/10.1200/jco.19.00151


Chemoradiation in Stage IIIB Cancer of the Uterine Cervix: A Review of the Zimbabwean Experience

"PURPOSE PURPOSE Cervical cancer remains the most common cause of cancer morbidity and mortality among Zimbabwean women. " Many patients are diagnosed with stage IIIB disease. PATIENTS AND METHODS We performed a retrospective review of data from hospital records for patients with stage IIIB disease who were treated over a two-year course at Parirenyatwa Group of Hospitals. At 3 months post-CCRT, one patient did not complete therapy, and 68. 5% had complete clinical tumor response. In those patients who were young, HIV uninfected, with less extensive disease, CD4+ of 500 cells/mm 3 or more, underwent four or more cycles of chemotherapy, received brachytherapy, and had no treatment breaks were found. CONCLUSION The research found that the use of CCRT to diagnose stage IIIB cervical cancer in Zimbabwe is low. Well-selected patients tolerate the therapy and have good early clinical tumor responses as expected. ".

Source link: https://doi.org/10.1200/jgo.19.00412

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions