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This study seeks to determine if bay leaf extract has a therapeutic effect in lowering uric acid levels in male white rats and determine what dose of bay leaf extract is most beneficial in lowering uric acid levels in male white rats.
Source link: https://doi.org/10.47918/jhts.v2i3.276
Uric acid is believed to be one of the most common antioxidants in human biological fluids. The aim of this research was to determine the efflux of uric acid from the intestinal intestine after intestinal I/R. After intestinal I/R, serosal to mucosal flux for uric acid was increased, and mannitol's was also increased. Bcrp homodimer's decrease in the quantity of Bcrp homodimer, which was crossed by an S-S bond, led to decreased uric acid transport mediated by Bcrp. In addition, BCRP S-S bond formation activity in Caco-2 cells was reduced by rotenone. Following intestinal I/R, serosal to mucosal flux for uric acid is greatly increased via the transcellular route mediated by Bcrp, but it is reduced after intestinal I/R. Bcrp's decreasing uric acid flux mediated by Bcrp is attributed to the absence of Bcrp S-S bond formation. Bcrp S-S bond formation inhibition can be due to mitochondrial dysfunction.
Source link: https://doi.org/10.18433/j3w896
Abstract Men have higher circulating uric acid levels than women. As a result of a dramatic rise in uric acid in adolescent boys, a sex difference in uric acid was established during adolescence. The rise in estradiol in girls over time was accompanied by a relatively stable level of uric acid during adolescence. After complete adjustment, both three fractions of estradiol were positively associated with uric acid in adolescent boys and girls. After complete adjustment, all three fractions of testosterone were positively associated with serum uric acid, and sex hormone-binding globulin was inversely linked to uric acid in adolescent boys. Estradiol is not inversely linked to circulating uric acid in adolescents, and the emergence of a sex difference in circulating uric acid in adolescent boys has been linked to elevated testosterone and lower sex hormone-binding globulin.
Source link: https://doi.org/10.1038/s41598-021-96959-4
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