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Urethral Stricture - DOAJ

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Last Updated: 23 November 2022

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Differential expression of miRNAs involved in biological processes responsible for inflammation and immune response in lichen sclerosus urethral stricture disease.

We wanted to investigate microRNA expression profiles in tissue samples from men undergoing urethroplasty in order to better understand the pathophysiology of lichen sclerosus urethral stricture disease. For RNA testing, a panel of areas diagnostic for LS or non-LS strictures was selected for RNA analysis. In a first screening report, 13 LS urethral strictures and 13 non-LS strictures were outlined by miRNA RT-qPCR arrays for 752 unique miRNA. 15 of these miRNAs individually demonstrated an area under the curve > 0. 90 for distinguishing between LS and non-LS strictures. MiR-155-5p specifically was found in LS vs. non-LS strictures, a 11-fold increase was found. Conclusions This is the first study to determine miRNA expression profiles in LS and non-LS USD. We discovered several miRNAs that are differentially expressed in USD generated by LS vs other etiologies, which may be useful as biomarkers of LS USD.

Source link: https://doi.org/10.1371/journal.pone.0261505


Testosterone, Urethral Vascularity, and Urethral Stricture Disease: A Review

In several organs, Testosterone is known to mediate vainogenesis by vascular endothelial growth factor and hypoxia inducible factor-u03b1 pathways. Androgen supplementation can aid in the case of testosterone deficiency, androgen supplementation can help with urethral vascularity. In addition, there seems to be a significant prevalence of testosterone deficiency in men with urethral strictures. Despite numerous advancements in our knowledge of testosterone's connection with the urethra over the past few years, more remains to be learned about the hormones of testosterone etiology, urethra stricture etiology, and whether testosterone deficiency and supplementation could influence urethral reconstruction outcomes.

Source link: https://doi.org/10.31083/j.jomh1807159


Analysis of expansion within a pressure inflated section of an urethral stricture model

However, experiments to determine the in-vivo behaviour of urethra with strictures are not fully investigated. In simulations that necessitate appropriate modeling of the human male urethra with strictures, the sensor's capabilities will be determined. An ideal actuator with sensor elements causing a pressure on the inner wall of this urethra was simulated. Three circumference measurement zones within the sensor height were introduced. The extension of tissue can vary depending on the sensor-actuator's location. The finite length of the actuator as well as the influence of tissue properties around the measurement zones were among the potential explanations for this variation. This is critical data for the interpretation of sensor results that would have been missing by the new technology. Simulations, according to this, are a fast and cost-effective way to validate new sensors prior to real experiments.

Source link: https://doi.org/10.1515/cdbme-2021-2147

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions