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Uthral tighture is attributed to scar tissue fibrosis, but the exact cause of the disease is uncertain. CircRNA microarray was used to determine circRNA expression profiles between human urethral scar tissue and normal urethral tissue. There were 296 differentially expressed genes between urethral scar tissue and normal urethral tissue, according to the results of circRNA microarray. To determine the circRNA-miRNA network, the first nine differentially expressed circRNA were selected. In vitro, Uthral scar fibroblasts were isolated from human urethral scar tissue and cultured in vitro. The proliferation of urethral scar cells has decreased dramatically following silencing around 0047339, and Collagen I and u03b1-smooth muscle actin limiting were also reduced. Circa 0047339 could raise the expression of TSP-1 by competitively binding miR-4691-5p as a competing endogenous RNA. Our results showed that circ_0047339 could promote urethral scar fibroblast proliferation and fibrosis via the miR-4691-5p/TSP-1 axis, thus encouraging the production of urethral stricture.
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