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Type 2 Diabetes - Springer Nature

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Last Updated: 09 June 2022

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Short chain fatty acids for the risk of diabetic nephropathy in type 2 diabetes patients

"Aims This research was designed to investigate the link between short chain fatty acids and diabetic nephropathy in type 2 diabetes patients. Methods We extracted the clinical and omics data of 100 T2D patients and 100 DN patients from a tertiary hospital from April 2018 to April 2019. In T2D, a restricted cubic splines was used to determine full-range fatty acids with DN. Query Logistic regression was used to determine odds ratio and confidence interval. The risk of DN was significantly elevated in serum due to the additive interaction of high propionate and high isobutyrate. High propionate and high isobutyrate also acted alone and synergistically to raise the risk of DN in T2D. The effect of high propionate copresence on DN risk was amplified by the presence of hypertension.

Source link: https://doi.org/10.1007/s00592-022-01870-7


Illness perception, medication adherence and glycemic control among primary health-care patients with type 2 diabetes mellitus at Port Said City, Egypt

"Aims" Despite the availability of a large number of antidiabetic drugs, many patients with type 2 diabetes mellitus do not have controlled glucose levels. This study was designed to assess illness prevalence, medication use, and glycemic control among primary care attendees with T2DM. In Port Said, Egypt, a random sample of 265 Egyptian T2DM patients was recruited from primary health-care facilities. The Brief Illness Perception Questionnaire was used to measure diabetes prevalence, while the 8-item Morisky Medication Adherence Scale was used to investigate medication use. There was a significant difference in MMAS-8 scores between two groups of the patients' disease duration, family history of T2DM, and glycemic control. Adding to that, there was a significant difference in HbA1c score found among different populations of patients in terms of disease duration, medications, complications, and family history of T2DM.

Source link: https://doi.org/10.1007/s13340-021-00567-6


Factors associated with atrial fibrillation in Japanese patients with type 2 diabetes mellitus: a cross-sectional study

"Aims Atrial fibrillation causes cardiovascular disease and mortality in diabetic patients. " Diabetes is a risk factor for AF, but the risk factors for AF among patients with type 2 diabetes, especially among Asian patients, are still unclear. We established the prevalence of AF in Japanese patients with T2D and outlined the AF-related causes. Patients with T2D were also included. We analyzed medical data from patients with and without AF. T2D-related AF was 5. 9%, but it increased in men than in women, and it became more prevalent in men than in women. As albuminuria or proteinuria progressed, the incidence of epidemic became greater as albuminuria or proteinuria increased, as the eGFR decreased. However, multiple logistic regression studies showed that there were no significant associations between AF and the presence of albuminuria or proteinuria. Conclusions In Japanese patients with T2D, older age, male sex, and reduced eGFR were all associated with AF.

Source link: https://doi.org/10.1007/s13340-021-00563-w


Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes

"The aim of this research was to identify the metabolite profiles related to plant-based diets and to determine the correlations between the identified metabolite profiles and the risk of type 2 diabetes. " Identities Within three prospective cohorts, we measured plasma metabolites from 10,684 individuals using the Plant-based Diet Index, a Healthy Plant-based Diet Index, and the Unhealthy Plant-based Diet Index. Using multivariable Cox proportional hazards regression, we investigated the prospective correlations between metabolite profiles and incident type 2 diabetes. Metabolites that could be used to support the connection between plant-based diets and type 2 diabetes risk was expanded. The metabolite profile score for uPDI and hPDI indicated an inverse relationship with incident type 2 diabetes, according to Metabolite profile results, although the metabolite profile score for uPDI was not linked to the risk. ".

Source link: https://doi.org/10.1007/s00125-022-05692-8


Incidence of interventions for diabetic retinopathy and serious lower-limb complications and its related factors in patients with type 2 diabetes using a real-world large claims database

"Aims To investigate the prevalence of diabetic retinopathy and severe leg disorders, as well as other disorders related to each intervention's incidence based on real-world claims from Japan. Patients with type 2 diabetes aged 20 to u201374 years on antidiabetic drugs were divided into two groups: u201cpatients with recently introduced antidiabetic drugs u201d and u201cpatients with continuing antidiabetic therapy were divided into two groups: u201cpatients with newly initiated antidiabetic drugs were divided into two groups: u201cpatients and u201d patients receiving continuing antihypogogue therapy We also divided Group 1 into the former and later periods, as well as investigating temporal shifts. While the incidence of retinopathy hardly changed during the study period, the incidence of lower-limb amputations decreased by 40%, with less statistical significance. Conclusions We investigated the incidences of the first retinopathy interventions and lower-limb amputations, as well as their secular trends in diabetic patients with diabetes, dividing by whether the antidiabetic drug was new or not. ".

Source link: https://doi.org/10.1007/s13340-021-00566-7


Association of gut microbiota with glycaemic traits and incident type 2 diabetes, and modulation by habitual diet: a population-based longitudinal cohort study in Chinese adults

"Little is known about the glycaemic control of gut microbiota throughout its life. " In a geographically diverse population, we sought to identify gut microbiota positively related to glycaemic traits and type 2 diabetes, and we investigated the cross-sectional correlation of diet or lifestyle causes with the identified gut microbiota. Methods The China Health and Nutrition Survey is a population-based longitudinal cohort that includes 15 provinces/megacities throughout China. To determine the connection between the HMI and incident type 2 diabetes, we developed a healthy microbiome index and Poisson regression. The outcomes were published after a follow-up of three years, and 123 type 2 diabetes cases were reported. We identified 25 gut microbial genera positively or inversely associated with glycaemic characteristics. Multiple gut microbiota genotyping and type 2 diabetes in a geographically diverse population were positively related to glycaemic signs and type 2 diabetes, as well as type 2 diabetes, which also highlighted the possibility of gut microbiota-based diagnosis or therapy for type 2 diabetes.

Source link: https://doi.org/10.1007/s00125-022-05687-5


Convergent Molecular Pathways in Type 2 Diabetes Mellitus and Parkinson’s Disease: Insights into Mechanisms and Pathological Consequences

"Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemic conditions. " Patients with T2DM also have a higher risk of experiencing Parkinson's disease, according to recent years. However, the molecular mechanisms underlying T2DM's interplay with PD pathogenesis remain uncertain, but the exact molecular mechanisms underlying the interplay between T2DM and PD pathogenesis remain unclear. However, new epidemiological reports have discovered that many common molecular pathways that play an important role in normal cell metabolism are independently implicated in T2DM and PD's development and etiopathogenesis. We summarize the research that has revealed the connection between T2DM and PD in this article.

Source link: https://doi.org/10.1007/s12035-022-02867-7


Glycemic control and its associated factors in type 2 diabetes patients at Felege Hiwot and Debre Markos Referral Hospitals

"Poor glycemic control is a significant cause of diabetic complications among type 2 diabetes mellitus patients and is a key public health issue. " In Felege-Hiwot and Debre Markos Referral Hospitals, this study sought to determine the glycemic control status and its associated factors among type 2 diabetes patients. Patients whose average fasting blood glucose reading for three consecutive visits was between 70 and 130 mg/dL were given Good glycemic control. T2DM patients who live in a rural area, older age, positive proteinuria, higher blood pressure, higher serum creatinine levels, longer visit duration, longer time T2DM since diagnosis, and persistent hypertension were all predictors of poorer glycemic control success for T2DM patients. ".

Source link: https://doi.org/10.1038/s41598-022-13673-5


The roles of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in development of diabetic nephropathy in patients with type 2 diabetes mellitus

"Background" is a film that traces MTHFR and MGP gene variations in DN development. "MTHFR C677T gene variant in the control group was found significantly different from the Hardy-Weinberg distribution p" [in the case.

Source link: https://doi.org/10.1007/s40200-022-01061-9


Associations of exposure to lead and cadmium with risk of all-cause and cardiovascular disease mortality among patients with type 2 diabetes

"The aim of this paper is to investigate lead and cadmium use in adult with type 2 diabetes in adults with all-cause and cardiovascular disease mortality. " According to both, the geometric mean concentrations of blood lead and cadmium were 19. 6 u03bcg/L and 0. 39 bcg/L. According to statistics, there were 3218 all-cause deaths for blood lead and 1237 all-cause deaths for blood cadmium during 72,279 and 37,017 person-years of sequel. Participants in the lowest tertiles of blood lead and cadmium had a death rate of 2. 09 for all-cause mortality in the joint study, compared to participants in the lowest tertiles of blood lead and cadmium. Patients with T2D who were exposed to lead and cadmium alone or in combination were significantly associated with a higher risk of death. These results show that limiting lead and cadmium exposure may help prevent premature death in diabetics.

Source link: https://doi.org/10.1007/s11356-022-21273-z

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions