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"Abstract Background Carbohydrate-restricted diets and intermittent fasting have been quickly gaining attention among the general population and patients of cardiometabolic disorders, such as overweight or obesity, diabetes, and hypertension. Methods A meta-analysis and systematic literature review of 66 articles on 50 randomized controlled clinical trials of carbohydrate-restricted diets and ten articles on eight RCTs of IF were published. A moderately-low carbohydrate or low carbohydrate diet may be considered a dietary strategy for weight loss in adults with overweight or obesity. MLCD can be used as a diet for improving glycemic control and lowering body mass in adults with type 2 diabetes. In comparison, a very low carbohydrate diet and IF are highly advised against in diabetics with diabetes. No recommendations have been made for VLCD and IF in adults with excess or obesity, and carbohydrate-restricted diets and IF in patients with hypertension, respectively, are available.
Source link: https://doi.org/10.1186/s40885-022-00207-4
"Abstract Heart disease with reduced ejection fraction is increasingly treated with drugs for type 2 diabetes mellitus. " The FIGHT trial randomized 300 participants with HFrEF and a new HF hospitalization to liraglutide versus placebo to determine mortality, HF rehospitalization, and a 6-month change in NT-ProBNP. Despite the fact that no clinical value of liraglutide existed, the trial population was greatly enhanced for people with T2DM. Changes in NT-proBNP and 6MWD, however, are correlated with shifts in functional outcomes beyond adjustment: factor 1, factor 4, factor 5, and factor 8 correlated with change in NT-proBNP and 6MWD, which were correlated with changes in functional outcomes beyond adjustment: change in NT-proBNP and 6MWD, respectively with change in T2DM status; factor 1, factor 4, factor 5, factor 5 correlated with changes in NT-proBNP and 6MWD NT-proBNP and 6MWD, factor 4 correlated with changes in correlated with changes in correlated with changes in correlated with changes in correlated with T2 correlated with changes in correlated with change in NT-proBNP and 6MWD correlated with T2 correlated with changes in NT-proBNP and 6MWD; however, factor 8 correlated with changes in 6MWDNP and 6MWD3 NT-proBNP and 6MWD We found metabolites of BCAA, urea cycle, and fatty acid metabolism as biomarkers of HFrEF outcomes, with reported differences in HFrEF patients with T2DM" in HFrEF patients.
Source link: https://doi.org/10.1038/s41598-022-12973-0
"The fatty liver index was used to determine the presence or absence of fatty liver disease in a MAFLD diagnosis. For MAFLD + MetS, the hazard ratio for CAD/CVD was 1. 33 /1. 41 for MAFLD only, 1. 78 /1. 36 for MetS only, and 2. 10 /1. 73 for MAFLD + MetS. For those with type 2 diabetes, the HR for MAFLD was 1. 29, for MetS only 1. 34, and for MAFLD + MetS 1. 22. Conclusions Distinguishing between MetS and/or MAFLD in the presence or absence of type 2 diabetes, as well as other sex, can help in accurately identifying patients at high risk of cardiovascular disease. ".
Source link: https://doi.org/10.1186/s12933-022-01518-4
"Abstract Objective Type 2 diabetes mellitus is often accompanied by undiagnosed dyslipidemia. " In coronary heart disease patients, research on the correlation of unconventional lipid markers with prediabetes and T2DM simultaneously is limited. Methods The study, which included 28,476 patients with CHD, included 28476 patients with CHD. Multiple logistic regression was used to compare the correlation of TG/HDL-C and other non-traditional lipid measurements with pre-DM and T2DM. T3 was found to have the highest relationship with both pre-DM and T2DM when dividing TG/HDL-C into tertiles, using T1 as a benchmark. TG/HDL-C's T2DM and pre-DM were also present in various sex, age, smoke, and drinking statuses. Conclusions Elevated non-traditional lipid measurements were strongly linked to pre-DM and T2DM in CHD patients, particularly TG/HDL-C. High TG/HDL-C was the risk factor with a strong correlation with pre-DM and T2DM. ".
Source link: https://doi.org/10.1186/s12933-022-01531-7
"Methods In the Jackson Heart Study, we did a cluster analysis of clinical, biochemical, and echocardiographic characteristics from 529 Blacks with diabetes. Results Cluster analysis sorted diabetics with diabetes into three specific clusters based on clusters. Compared to Cluster 1, the 3rd cluster in Cluster 1 had an elevated risk of cardiovascular disease, while Cluster 2 had a similar risk of outcome. Conclusions Among Blacks with diabetes, cluster analysis revealed three distinct echocardiographic and biomarker phenotypes, with cluster 3 showing worse results and underscoring the prognostic value of sub-myocardial dysfunction. ".
Source link: https://doi.org/10.1186/s12933-022-01501-z
"However, the additive effects of T2DM on left ventricular function in NIDCM remain unclear. " According to NIDCM participants, we wanted to investigate the effect of comorbid T2DM on LV deformation. Measurements were performed on LV geometry, function, and LV global strains, including peak strain, peak systolic strain rate, and peak diastolic strain rate in the radial, circumferential, and longitudinal directions. Using multivariable linear regression tests, the determinants of reduced LV myocardial strain for all NIDCM patients and NIDCM patients were determined. Comparisons versus normal controls Both NIDCM and NIDCM patients had elevated LV end-diastolic and end-systolic volume index and reduced LV ejection fraction, as compared to normal controls. LV global radial PS and longitudinal PS, PSSR-L, and PDSR-L were all worse in NIDCM patients with poor glycemic control than those with good glycemic control, according to a Subgroup report. HbA1c, a characteristic of reduced LV myocardial strain among NIDCM patients with T2DM, was found to be correlated with reduced LV myocardial strain.
Source link: https://doi.org/10.1186/s12933-022-01533-5
"This self-controlled case series research intends to determine whether metformin use and SGLT2i-associated erythrocytosis may have an effect on cardiovascular health. " Methods T2D patients with metformin and/or SGLT2i prescriptions between 2015 and 2020 were identified among the Hong Kong population. The patient-time window was divided into four mutually exclusive windows: without SGLT2i use; pre-SGLT2i period; without metformin use; and exposure to the drug combination; and patient-time divided into four time window: u2018baseline period; without metformin use; u2018baseline period; and early exposure to the drug combination. Another SCCS model was used to determine the correlation between erythrocytosis and cardiovascular events related to SGLT2i exposure. SGLT2i experience with erythrocytosis; SGLT2i exposure without erythrocytosis; and the absence of SGLT2i exposure without erythrocytosis were among the four mutually exclusive risk periods highlighted in this report. Compared to metformin's use without SGLT2i, SGLT2i's inception was correlated with reduced risks of composite CVD, CHD, and HHFu2014regardless of the presence despite a lack of information. HHF-inhibitors who had erythrocytosis were at a reduced risk of HHF than those who did not. ".
Source link: https://doi.org/10.1186/s12933-022-01520-w
"Abstract Background Older adults with type 2 diabetes are at a greater risk of experiencing common geriatric syndromes and have a lower quality of life. " It's difficult to decide whether physical fitness can be influenced by increased air pollution in Pennsylvania, particularly in developing countries with a high air pollution problem. We wanted to investigate the joint effects of PA and long-term exposure to air pollution in senior adults from China. Conclusions The PA health benefits for the prevention of type 2 diabetes in older adults outweighed the risks of air pollution except in extreme air pollution situations, and it was suggested that if the air quality of residence is poor, the PA levels should not exceed 40 MET-h/d. ".
Source link: https://doi.org/10.1186/s12877-022-03139-8
"Abstract Aims" is a COVID-19 pandemic that has challenged health care and its ability to provide essential health services while responding to COVID-19. This report explores the pandemicu2019s impact on health care use among patients with type 2 diabetes in Finland's North Karelia region. Methods This retrospective cohort study used electronic health records of 11,458 type 2 diabetes patients, including all primary and specialised care contacts in 2019 and 2020. We reviewed diabetes and dental healthcare contacts among primary care nurses, physicians, and dentists, as well as all emergency visits in specialized care. Emergency visits dropped drastically at the start of the lockdown period, but a u201crebound trend was observed, so after the lockdown, the number of emergency visits in 2020 exceeded the previous year's record. ".
Source link: https://doi.org/10.1186/s12913-022-08105-z
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