Advanced searches left 3/3

Type 2 Diabetes - Astrophysics Data System

Summarized by Plex Scholar
Last Updated: 09 May 2022

* If you want to update the article please login/register

Role of Glucokinase Enzyme in the Treatment of Type 2 Diabetes

Diabetes mellitus is a disease that affects people around the world, and the rate at which the number of diabetes patients rises places medical professionals under a lot of pressure to treat it effectively. GK is a key component of glucose homoeostasis regulation, thanks in the presence of GK in pancreatic and hepatic cells. It acts as both a "glucose sensor" and a "glucose gate keeper" in the pancreas and liver's cells. Small, rapidly acting GK-infused GK give a different alternative for restoring/improving glycemic homeostasis in T2DM patients.

Source link: https://ui.adsabs.harvard.edu/abs/2022ECSTr.107.9065S/abstract


The bidirectional interaction between climate change and type 2 diabetes burden

Today, type 2 diabetes and climate change are the most pressing topics worldwide, with type 2 diabetes and climate change. Interestingly, T2D directly or indirectly influences climate change and vice versa, while global change contributes to the increased risk and mortality of various non-communicable diseases, including T2D. This report seeks to synthete and provide the full picture related to interactions between climate change and T2D burden, which is still being a relatively new area in the Indonesian healthcare industry. Multiple predisposing causes for diabetes's rapid rise are also acting as a risk vector that promotes climate change. While extreme temperature raises the susceptibility of diabetic patients to life-threatening conditions such as dehydration and heatstroke, diabetic subjects are vulnerable to life-threatening conditions such as dehydration and heatstroke. Climate change and T2D burden, which should be a top priority for the government's attention in achieving the Sustainable Development Goal, particularly for NCD with type 2 diabetes, is bidirectional.

Source link: https://ui.adsabs.harvard.edu/abs/2022E&ES.1016a2054D/abstract


B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

B cells from obese mice have a proinflammatory cytokine profile when compared to lean mice B cells. Obese B cell cytokines, inflammatory B- and T-cell cytokines, adipose tissue inflammation, and insulin resistance have reduced systemic inflammation, inflammatory B- and T-cell cytokines, adipose tissue inflammation, and insulin resistance in obese B cell null mice, according to published in vivo studies, compared to obese WT mice. In IR, this rise contrasts with the dramatically reduced number of Tregs in obese compared to lean WT mice, who may be critical regulators of T-cell functions that have previously been shown to play significant roles in IR. We report that T-cell cultures from T2D subjects promote proinflammatory T-cell function in obesity/T2D via contact-dependent mechanisms. B cells are thought to be key mediators of inflammation in T2D due to their ability to promote proinflammatory T-cell function and concealment of a proinflammatory cytokine profile, according to these results.

Source link: https://ui.adsabs.harvard.edu/abs/2013PNAS..110.5133D/abstract


Machine learning prediction of non-attendance to postpartum glucose screening and subsequent risk of type 2 diabetes following gestational diabetes

Following gestational diabetes mellitus pregnancy, the aim of this research was to determine the reasons associated with the non-attendance of immediate postpartum glucose test using a machine learning algorithm. Methods: At the George Eliot Hospital NHS Trust, United Kingdom, a retrospective cohort study of all GDM women for postpartum glucose test results between January 2016 and December 2019, which was a retrospective cohort study. A total of 233 women underwent a subsequent glucose test at least once within the first two years of birth, with 24% suffering dysglycaemia. According to women who underwent a postpartum glucose test, those who did not attend had a higher risk of type 2 diabetes than those who did not attend. Women who did not attend postpartum screening do not appear to have an elevated risk of type 2 diabetes and increased conversion to type 2 diabetes by two years post-delivery. Using simple antenatal causes, a machine learning algorithm can determine women who are unlikely to attend a postpartum glucose test.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1764648P/abstract


Obesity among type 2 diabetes mellitus at Sidama Region, Southern Ethiopia

The current investigation, therefore, is designed to identify obesity and its associated risk among patients of type 2 diabetes mellitus in the Sidama region, Ethiopia. Method The prevalence of obesity and its associated risk among patients with type 2 diabetes at Hawassa University Comprehensive Specialized Hospital and Yirgalem General Hospital was determined by a quantitative cross-sectional survey design from October 16, 2018 to December 21, 2018. Every study participant was given a 4ml blood sample that was analyzed for a lipid profiling test, which was then analyzed for lipid profile test. Conclusion The majority of the study participants were male and 68% of the participants were aged > 45 years old. The overall prevalence of overweight and obesity among the study participants was 36. 3% and 18. 8% respectively. Obesity in type 2 DM patients is primarily due to Sex and TG. Conclusion Overweight and obesity were prevalent among type two diabetic patients, as described.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1766716B/abstract


Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3

Noncoding SNPs linked to type 2 diabetes and obesity in linkage disequilibrium blocks encompassing HHEX-IDE and FTO, according to Sladek R, et al. In transgenic mice and zebrafish, human highly conserved noncoding elements in LD, which may lead to expression in endoderm or pancreas. Both HHEX and SOX4 have been implicated in pancreas formation and insulin secretion control, but IRX3 had no prior involvement with pancreatic function or development.

Source link: https://ui.adsabs.harvard.edu/abs/2010PNAS..107..775R/abstract


An Online Stochastic Optimization Approach for Insulin Intensification in Type 2 Diabetes with Attention to Pseudo-Hypoglycemia

Hypoglycemia can be present in the subjects with insulin therapy for type 2 diabetes patients, depending on how quickly their blood glucose levels are reduced. By using an online stochastic optimization tool for a specific cost function, the proposed policy refines the parameters of a proposed control measure. Using simulations of three separate models, the insulin calculation strategy is demonstrated and compared to current insulin calculation algorithms.

Source link: https://ui.adsabs.harvard.edu/abs/2022arXiv220411380A/abstract


Cardiovascular risk in newly diagnosed type 2 diabetes patients in India

Type 2 diabetes mellitus worldwide continues to rise, in particular in India, in India. More cardiovascular event-free life years will be achieved by early T2DM diagnosis and appropriate monitoring. However, information regarding the cardiovascular profile of newly diagnosed T2DM patients is still limited. The aim of this research was to determine the prevalence of cardiovascular disease risk among newly diagnosed T2DM patients in India. Based on LAI criteria, the newly diagnosed T2DM-diagnosed patients in India 2,007 were classified as "High risk" and 3,073 were classified as "Very high risk" and 3,073 were classified as "High risk" and "Very high risk" based on LAI criteria. In addition, 4,192 patients appeared to have at least one cholesterol abnormality, and, if the new LAI guidelines are followed, 96. 5% had lipid levels above target. According to a QRISK3 report, Indian diabetic diabetics had an average CVD risk of 15. 3 percent compared to 12. 3%. Conclusions: T2DM patients that have recently treated are at a high risk of ASCVD.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1763619U/abstract


Association between use of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptidase 4 inhibitors with kidney outcomes in patients with type 2 diabetes: A systematic review and network meta-analysis

This review was conducted in the United States to compare the effectiveness of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptide 4 inhibitors in kidney transplants in patients with type 2 diabetes using network meta-analysis. Participants with type 2 diabetes were included in randomized clinical trials involving type 2 diabetes, GLP-1 agonists, and DPP-4 inhibitors, for which SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors were compared with placebo or no treatment, respectively. However, GLP-1 receptor agonists were most likely to be the most effective of the three drugs in reducing composite renal events. SGLT-2 inhibitors were associated with reduced risk of AKI events compared to the control groups, GLP-1 receptor agonists, and with DPP-4 inhibitors. Conclusions (in this network meta-analysis) Although none of the three new antidiabetic drug classes reduced the composite renal events in people with type 2 diabetes, GLP-1 receptor agonists may have been more beneficial.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1767025Y/abstract


Identification of the shared gene signatures and pathways between sarcopenia and type 2 diabetes mellitus

Background Sarcopenia is characterized by the age-associated loss of bone mass and strength that persists as an aging population and plays a significant role in senior disability. Methods We developed a transcriptomic analysis of skeletal muscle biopsy samples in sarcopenia patients and proliferating myoblasts and discriminating myotubes from people with T2DM. When sarcopenia and T2DM were both found, 15 common genes correlated with sarcopenia and T2DM were discovered simultaneously, and 3 genes of them were designated as hub genes. In addition, the TF-gene interactions network and TF-miRNA core regulator network also mentioned that part of TF and miRNA, as a key regulator in sarcopenia and T2DM at the same time. Conclusion This research found that sarcopenia and T2DM may have common pathogenesis and exposed new biological targets and strategies for early diagnosis and effective treatment of sarcopenia and T2DM.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1765221H/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions