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Trimethoprim - Europe PMC

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Last Updated: 18 November 2022

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Sudden Conjunctivitis, Lymphopenia, and Rash Combined With Hemodynamic Changes (SCoRCH) After Trimethoprim-Sulfamethoxazole Use: A Case Series Study of a Hypersensitivity Reaction.

After being treated with TMP-SMX at a large university hospital system from January 2013 to March 2022, a retrospective case series research of 7 patients who experienced a consistent rash, hemodynamic changes, and end-organ dysfunction. Exposures Treatment with TMP-SMX within 2 weeks of the reaction was announced. Generalized sunburn-like erythema without scale, conctivitis, and mild facial and acral edema were the most common mucocutaneous findings. Patients with prior exposure ranged from 4 to 11 days after drug initiation, with three patients having previous exposure to TMP-SMX and experiencing symptoms in 1 day or less. Both patients had lymphopenia and signs of end-organ disease, with either kidney or liver involvement. In the case of recent TMP-SMX use, this retrospective case series shows that SCoRCH should be considered in the differential diagnosis of patients with acute generalized sunburn-like erythema, conctivitis, systemic signs, and hemodynamic changes.

Source link: https://europepmc.org/article/MED/36350597


Multisensory Systems Based on Perfluorosulfonic Acid Membranes Modified with Functionalized CNTs for Determination of Sulfamethoxazole and Trimethoprim in Pharmaceuticals.

Sulfamethoxazole and trimethoprim are two synthetic bacteriostatic agents. The influence of the CNT concentration and the chemical properties of their surface, as well as preliminary ultrasonic treatment of the polymer and CNT solution prior to the casting of hybrid membranes was shown. An array of multi-sensitive sensors based on the membranes of 1. 0 wt% of CNTs with sulfonic acid or trimethoxysilanol groups enabled us to perform simultaneous determination of sulfamethoprim and trimethoprim in aqueous solutions with a concentration ranging from 1. 0 - 10 -3 M. U00d7 10-7 and 1. 3 10-7 -7, U00d7 10-7 and Trimethoprim's detection limits were within 3. 5 u00d7 10-7 and 1. 3 -7;u00d7 10-7 7 -7 u041c. Comparing to the manufacturer's reported values, the relative errors of sulfamethoxazole and trimethoprim determination in the combination drug were between 4% and 5%, respectively.

Source link: https://europepmc.org/article/MED/36363646


Severe hyponatremia due to trimethoprim-sulfamethoxazole-induced SIADH.

Hyponatremia, a serum sodium level of 135 mEq/L, is the most common electrolyte abnormality in 5% to 35% of hospitalized patients. Trimethoprim-sulfamethoxazole and spironolactone use combined with trimethoprim-sulfamethoxazole and spironolactone can cause serious drug interactions that can elevate the risk of hyponatremia, hyperkalemia, and overall mortality. We report the case of an elderly female with severe hyponatremia exacerbated by trimethoprim-sulfamethoxazole-sulfamethoxazole superimposed on a persistent yet mild hyponatremia.

Source link: https://europepmc.org/article/MED/36313270


Investigation on the Usefulness of Sulfamethoxazole Trimethoprim Combination Small Tablets in Pediatric Pharmacotherapy: A Single Center Observational Study Using a Questionnaire.

Sulfamethoxazole trimethoprim combinations are used to reduce infection in immunocompromized patients. Traditional ST combination tablets are large and granules are not recommended in pediatric patients due to their harsh and bitter taste in the mouth. A research into the usability of sTab in pediatric patients was undertaken before a new formulation of smaller tablets was approved. All children who started using the ST combination in our hospital between August 2021 and August 2022 were eligible. After switching to sTab, the number of tablets per dose was 1 tablet and was 4 tablets. In five cases for cTab, negative in seven and negative in 10, positive in 8, neutral in 7, and negative in 12 cases for granules, respectively. The switch to sTab increased acceptability and reduced the burden of administration, reducing the burden of monitoring, implying that sTab is a user-friendly formulation in pediatric drugs.

Source link: https://europepmc.org/article/MED/36291534


Glucose Incorporated Graphite Matrix for Electroanalysis of Trimethoprim.

TMP is often used alongside sulfonamides to treat bacterial infections in humans and animals, and it is also used to treat bacterial infections in humans and animals. Electrochemical properties were determined using a 0. 5 mM TMP solution at optimal pH 3. 4. TMP's electro-oxidation of TMP was investigated at a variety of 0. 05 to 0. 55 V/s, with the effect of scan rate on the electro-oxidation of TMP. Proton transfer during oxidation was detected by a variety of pH and scan rate variations. For the electrochemical oxidation of TMP, a known and effective electrode interaction and reaction mechanism was suggested. The tablet, as well as the differential pulse voltammetry technique, showed that the chosen method and manufactured electrode were effective in the concentration range from 9. 0 -7 to 1. 0 (4) M. , as shown by a quantitative analysis.

Source link: https://europepmc.org/article/MED/36291048

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions