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Despite significant advancements in diagnostic and therapeutic technologies, lung cancer remains the leading cause of cancer-related mortality worldwide. About 85% of lung cancer cases are due to non-small cell lung cancer. However, the effects of antipsychotics on NSCLC must be investigated further. We investigated the effects of trifluoperazine, a commonly used antipsychotic drug, and its synthetic analogs on A549 human lung cancer cells. TFP-related genes and pathways that can be directly related to improved survival rates in lung cancer patients. The expression of genes associated with A549 cells' apoptosis and survival of A549 cells was reduced by 3dc treatment. In all experiments, including in vivo studies of metastatic lung cancer formation, 3dc had more potent anticancer effects than TFP. In addition, this review highlights a synthetic TFP analog that may be a promising lung cancer treatment.
Source link: https://doi.org/10.3390/biomedicines10051046
Gastric erosion is a multifactorial etiological disorder. The aim of this study was to determine the therapeutic effects of trifluoperazine on gastric lesion caused by cold-water stress and ethanol in rats. Animals were anesthetized 1 h after ethanol gavage or 4 h immersion in cold water. Both models resulted in a significant rise in MDA level and a decrease in SOD and CAT activity. In both cases, pre-treatment with TFP in doses of 10 and 20 mg/kg significantly raised the activity of SOD and CAT enzymes, as well as reduced the amount of MDA. Because of its antioxidant properties and inhibition of toxic oxidant release in the stomach tissues, TFP demonstrated gastric mucosal protection against oxidative damage caused by ethanol and cold-water stress. In rats, the therapeutic value of trifluoperazine against ethanol and cold water stress-induced gastric lesions is unknown.
Source link: https://doi.org/10.30476/tips.2021.92622.1112
A new, simple, fast, specific, and stable platform for simultaneous quantification of trihexyphenyl hydrochloride, trifluoperazine hydrochloride, and chlorpromazine hydrochloride from mixed tablet formulation has been developed and validated. A controlled degradation experiment shows that capability is established by forced degradation testing. 'u03bcg/mL, 12. 5-367. 5 g/mL respectively, and Chlorpromazine hydrochloride, trihexyl hydrochloride, trifluoperazine hydrochloride, and Chlorpromazine hydrochloride quantification from 5 to 15 bcg/mL, 12. 5- 37. 5 u03bcg/mL respectively.
Source link: https://doi.org/10.1155/2010/529386
The primary treatment for metastatic bladder urothelial carcinoma is Cisplatin-based chemotherapy. Bcl-xL knockdown by siRNA resensitized cisplatin-resistant cells to the cytotoxic effect of cisplatin. TFP potentiated cytotoxicity in T24/R cells by co-treatment with TFP. TFP alleviated cisplatin resistance to T24/R, resulting in concurrent suppression of Bcl-xL. paraphrase mice, according to In vivo studies, TFP alone effectively killed the T24/R xenograft in nude mice. On the T24/R xenograft, the anti-tumor effect of cisplatin enhanced with TFP co-treatment on the TFP xenograft. With simultaneous Bcl-xL downregulation, we found that TFP effectively blocked cisplatin-resistant UCs and circumvented cisplatin resistance in our results.
Source link: https://doi.org/10.3390/ijms20133218
Hence far, TFP's role in MM has not been clarified. Cellular apoptosis was reduced when compared to TFP and rapamycin, a potent autophagy promoter, in comparison to TFP alone. TFP also reduced nuclear protein 1 expression, which we also discovered. Cells stably overexpressing NUPR1 showed a higher viability than cells treated with nonspecific control in the presence of TFP. Following NUPR1 overexpression, autophagy inhibition and apoptosis induction caused by TFP were both reversed in MM cells.
Source link: https://doi.org/10.1002/2211-5463.12960
Abstract Background: Abstract Background In patients with glioblastoma, resistance to adjuvant radiotherapy is a major cause of treatment failure. Autophagy inhibitors have been shown to improve radiotherapy for specific solid tumors. In vitro and in vivo, we investigated the radiosensitivity effects of the antipsychotic drug trifluoperazine on GBM. To determine the efficacy of TFP therapy, Methods U251 and U87 GBM cell lines, as well as GBM cells from a primary human biopsy were used in vitro and in vivo. TFP cells treated with TFP had an IC50 value of 16, 15 and 15. 5 u03bcM, respectively. We can tell that down-regulation of cathepsin L could explain TFP's radiosensitivity, which could explain TFP's radiosensitivity. Conclusions This report provides a strong support for further clinical trials into the combination therapy of TFP and radiation to treat GBM patients.
Source link: https://doi.org/10.1186/s13046-017-0588-z
In its first-order derivative spectrum, a chromogenic reaction of TFPH and potassium persulfate at low pH leads to an orange-red radical cation with maximum absorption at 502 nm. With a 4 M H2SO4 solution, the TFPH radical cation solution was created by reacting 0. 5 mL of the solution with K2S2O8 and diluting to 100 mL. The proposed assay is less costly and requires just 20 min for the construction of a robust ABTS radical cation system in comparison to ABTS' assay, in which almost 12-16 h are needed for preparation of a stable ABTS radical cation solution. The present assay has the advantage over ABTS in that it can be used to determine the antioxidant activity of the samples, which are typically found at a pH of less than 1.
Trifluoperazine, a high-potency antipsychotic drug, can either combat or promote suicidal cell death or apoptosis. Erythrocytes may develop eryptosis, which is characterized by phosphatidylserine exposure at the cell surface and cell shrinkage, similar to apoptosis. We investigated whether TFP treatment of erythrocytes promoted phosphatidylserine exposure, cell death, and calcium influx, whether it affects S-nitrosylation or not, and whether these effects are restricted by NO. TFP exposure in human erythrocytes to TFP greatly raised the percentage of annexin-V-binding cells, [Ca2+]i, and decreased S-nitrosylation. TFP's effect on annexin-V-binding was not harmed by removal of extracellular Ca2+ alone, but it was significantly hampered by pre-treatment with sodium nitroprusside, which was greatly enhanced by the removal of extracellular Ca2+. Ca2+ ionophore ionomycin triggered annexin-V-binding and cell shrinkage in a 3 hour treatment, but cell shrinkage were fully reversed after the removal of extracellular Ca2+. TFP promotes eryptosis and reduces protein S-nitrosylation, which can be reduced by nitroprusside.
Source link: https://doi.org/10.1159/000479838
A new version of an indirect atomic absorption spectrometric method was developed for the determination of low amounts of trifluoperazine hydrochloride in pure and pharmaceutical dosage forms with good consistency and precision. AAS's determination is largely determined by AAS, depending on the emergence of metal complex between the drug and palladium to produce orange-yellowish product extractable in organic solvent prior to its aspiration into an air-acetylene flame. Both direct calibration and standard additions techniques were used to determine TFPH in the drug stelazine, and the estimated value was 4. 88 and 4. 87 mg per unite, respectively, to the claimed value of 5 mg per unite.
Source link: https://doi.org/10.1155/2010/153861
Method A is a numerical derivative of ratio spectra, which can be used to measure TPZ at 213 and 228 nm, and DEG at 213 and 227 nm, ISO at 213 and 220 nm. Both Methods B, 355 and 339 nm for TPZ, ISO, and DEG, respectively, determine the mean centered ratio spectra for TPZ, ISO, and DEG.
Source link: https://doi.org/10.1016/j.jscs.2012.10.003
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