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Treatment of Cancer - Europe PMC

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Last Updated: 18 April 2022

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Epigenetic drugs induce the potency of classic chemotherapy, suppress post-treatment re-growth of breast cancer, but preserve the wound healing ability of stem cells.

Our review explores: The cytotoxicity of classic paclitaxel chemotherapy on triple negative breast cancer alone and in combination with epigenetic agents. The effects of paclitaxel in combination with and without epigenetic therapy on the post-treatment survival and wound healing of adipose stem cells are unclear. Also, the combination of paclitaxel and epigenetic therapy may result in cancer toxicity that is safe to TNBC cells after the drugs' removal with little effect on ASCs wound healing ability. Epigenetic drugs in comparison to traditional chemotherapy are cytotoxic to TNBC cells and reduces post-treatment recovery of TNBC while maintaining ASC wound healing ability.

Source link: https://europepmc.org/article/MED/35389825


Nano-liposomal zein hydrolysate for improved apoptotic activity and therapeutic index in lung cancer treatment.

Lung cancer is one of the most common cancers in the world with a high mortality rate. Zein is a protein compound whose protein isolate is ineffective and whose protein hydrolysis produces biological activity. The effects of zein hydrolysate and nano-liposomal ZH were investigated on the human A549 cell line in this research. In conclusion, liposomes enhanced ZH's performance and drastically reduced the IC 50 value of ZH. These findings revealed the experimental evidence that N-ZH with good anticancer activity can be used as a therapeutic agent and treatment for lung cancer prevention in future clinical trials.

Source link: https://europepmc.org/article/MED/35363101


Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment.

Lung cancer is the most common cause of cancer death worldwide, and chemotherapy for non-small cell lung cancer remains a challenge in clinic, particularly for non-small cell lung cancer. Biotin conjugation significantly enhanced the carrier's internalization by 1. 2-fold when compared to other non-targeted mixed micelles, according to cellular uptake results. Que-MMICs could cause greater cytotoxicity than Que-MICs and free Que to A549 cells, which effectively promoted apoptosis and reduced cell cycle, according to In vitro results, which efficiently induced cytotoxicity and interrupted cell cycle. Also, Que-MMICs demonstrated satisfactory tumor targeting capability and antitumor efficacy, possibly due to a combination of increased permeability and retention as well as a robust targeting feature.

Source link: https://europepmc.org/article/MED/35343862


Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment.

Patients with prostate cancer bone metastasis are currently no longer symptomatic, but it was deemed invasive to identify the appropriate treatment protocols. The relationship between cancer cells and bone microenvironment plays a significant role in prostate cancer bone metastasis, particularly the Sonic hedgehog protein signaling in the bone microenvironment. The SHH promotes osteoblast maturation and osteoblast formation, but osteoblast secretes RANKL aids in osteogenesis. This research, published in the United Kingdom, shows that bone-targeting calcium phosphate lipid hybrid nanoparticles loaded with docetaxel and SHH siRNA for PCa bone metastasis treatment. This DDS, which is based on NPs, provides an excellent method for treating PCa bone metastasis.

Source link: https://europepmc.org/article/MED/35285760


Metal nanoparticles as a promising technology in targeted cancer treatment.

Cancer research is on the rise. Metal nanoparticles' use as alternative chemotherapeutic drugs is on the rise in cancer research. Metal NPs are versatile in a variety of industries. For cancer therapy, the possibility of several types of metal NPs for tumor targeting will be discussed. Metal NPs for solid tumors will be reviewed in vivo. Also reviewed will be the risk factors involved in the clinical use of metal NPs.

Source link: https://europepmc.org/article/MED/35209786


Loading of "cocktail siRNAs" into extracellular vesicles via TAT-DRBD peptide for the treatment of castration-resistant prostate cancer.

DRBD, a 3TD fusion protein, was co-expressed with a TAT peptide co-expressed with DRBD. The increase of integrated yellow fluorescence in the engineered EVs demonstrated by TIRFM and the decline in zeta potential absolute values, assuaging co-localization of siRNA with EVs, which indicated that siRNA was successfully delivered into WPMY-1 EVs. According to a qRT-PCR review, the mRNA content of FLOH1, NKX3, and DHRS7 had dramatically reduced when cells were treated with engineered EVs packed with siRNAs mixtures relative to the level of untreated cells. The results of western and flow cytometry results show that engineered EVs' siRNA mixture delivery can effectively downregulate AR expression and induce LNCaP-AI cell apoptosis. The uptake of the EVs and the significantly downregulated expression of three genes suggested that TAT might be effective siRNA carriers by keeping the cargo's functions intact.

Source link: https://europepmc.org/article/MED/35171081


Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid carriers.

Purpose Colorectal cancer is the third most common cancer diagnosis, and this report aimed to create a conatumab-designed, irinotecan prodrug, and quercetin co-loaded delivery system for combined and targeted colorectal cancer therapy. On CRC cells and mice xenograft, In vitro and in vivo antitumor effectiveness of NLC was assessed. C I-p/Q NLC uptake in HT-29 cells was over 70%, according to the report. In hypoxic environments, a reactive oxygen species sensitive irinotecan prodrug formulation demonstrated enhanced drug release ability. Conclusion The conatumab-decorated, ROS sensitive prodrug containing a nano-system provides a promising platform for CRC therapy, according to the author.

Source link: https://europepmc.org/article/MED/35049388


Does the type of biopsy used for diagnosis impact subsequent treatment selection in prostate cancer patients?

Purpose: Multiparametric magnetic resonance imaging targeted biopsy has emerged as an improvement to systemic prostate biopsy with increased diagnostic accuracy. The aim of this research was to see if biopsy modality had an effect on prostate cancer treatment. Methods We conducted a retrospective review of patients with newly diagnosed non-metastatic PCa at our hospital. On multivariate analysis, biopsy type did not influence the decision to pursue treatment, but not predict the decision to seek medical attention. On multinomial regression results, biopsy type did not influence AS selection over RP or RT over RP over RP. Conclusions Biopsy techniques did not have any effect on patients with new PCa diagnosis.

Source link: https://europepmc.org/article/MED/34983290


Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer.

In comparison to Celastrol, the Cel-CSO contained a ten percent solubility with excellent aqueous solubility. Cel-CSO significantly reduced tumor formation, stimulated apoptosis, and effectively stopped tumor formation in human pancreatic cancer cells by ceasing tumor growth. Cel-CSO's anticancer therapy, improved the circulation time of Celastrol, and reduced the risk of subacute toxicity, demonstrating that CSO can be a promising Celastrol delivery system for pancreatic cancer therapy.

Source link: https://europepmc.org/article/MED/34964425


Mechanism of Elian granules in the treatment of precancerous lesions of gastric cancer in rats through the MAPK signalling pathway based on network pharmacology.

Context Elian Granules has been used in the treatment of precancerous lesions of gastric cancer, with good results. Objects: Objectives: The underlying mechanisms of Elian granules in treating PLGC by the mitogen-activated protein kinase signaling pathway based on network pharmacology are investigated. Specific Pathogen Free male Sprague Dawley rats were randomly divided into several species, model, and Elian granule groups. For 24 weeks, both the model and Elian granule groups were administered standard saline and Elian granule intragastric solution intragastric administration. Western blotting revealed the protein expression of p-JNK and p-38. The Elian granule group's expression of p-JNK and p-38 proteins was significantly higher than the model group. Elian granules may play a vital role in the treatment of rat PLGC by up-regulating the expression of p-JNK and p-38 proteins in the MAPK signaling pathway, providing a scientific basis for clinical use.

Source link: https://europepmc.org/article/MED/34962453

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions