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Treatment Trial - Zenodo

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Last Updated: 06 July 2022

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Examining what factors mediate treatment effect in chronic low back pain: A mediation analysis of a Cognitive Functional Therapy clinical trial

Cognitive Functional Therapy is a physiotherapist-led intervention for people with non-specific low back pain that involves biopsychosocial pain education, graded movement exposure, and lifestyle counseling. Methods An international randomized controlled trial, including 206 participants with CFP in Ireland, supports CFT’s success for reducing disability but not pain, but not pain, compared to a group exercise and education intervention. Certain psychological and lifestyle causes were used to determine whether CFT's effect on disability and pain relief are mediated by certain psychological and lifestyle causes. Functional disability and pain intensity were measured at 12 months, according to the results, which were both functional disability and pain intensity. Findings This causal mediation study shows that the majority of benefit of CFT for disability is due to increased pain self-confidence. Conclusion Conclusion: CFT did not succeed the majority of the hypothesized mediators, and these mediators were not familiar with disability or pain, and they were not associated with either disability or pain.

Source link: https://zenodo.org/record/6760133


Amoxicillin plus Clavulanic Acid Vs Amoxicillin in the Treatment of Community Acquired Pneumonia in Children: A Double-Blind, Randomized, Controlled Trial

Since 2014, WHO recommendations for the care of Community Acquired Pneumonia have been updated, amoxicillin is the first choice for oral antibiotic therapy in domiciliary care of children. A study was conducted to determine the cure rate of oral amoxicillin plus clavulanic acid in children with CAP. Oral amoxicillin or amoxycillin plus clavulanic acid was used by patients for 5 d and then for 2 mo, 5 th d, and 2 mo. Compared to the amoxicillin group, the cure rate of CAP in the amoxicillin plus clavulanic acid group was noticeably higher.

Source link: https://zenodo.org/record/6626610


A randomised controlled trial to evaluate a medication monitoring system for TB treatment

Perpetuacute's OBJECTIVE: To evaluate the success of a medication event reminder tracking system and treatment adherence in patients with drug-susceptible pulmonary TB patients. There was no significant difference in the adherence results; however, the percentage of patients who missed at least one dose and patients with more than 10% of total doses missed were lower in the intervention group; however, patients with more than 10% of total doses missed were not significant. CONCLUSION: The use of MERM in the second phase of therapy produced a significant rise in the treatment success rate in patients with drug-susceptible pulmonary TB.

Source link: https://zenodo.org/record/6473374


High-dose ivermectin for early treatment of COVID-19 (COVER study): a randomised, double-blind, multicentre, phase II, dose-finding, proof-of-concept clinical trial

In vitro, high doses of ivermectin showed antiviral activity against SARS-CoV-2. The purpose of this investigation was to investigate the safety and effectiveness of high-dose ivermectin in lowering viral load in people with early SARS-CoV-2 disease. placebo; single-dose ivermectin 600 bcg/kg plus placebo for five days; and single-dose ivermectin 1200 u03bc/kg/kg/kg for five days; and single-dose ivermectin 1200 u03bc/kg/kg/kg/kg/kg/kg for 5 days were divided by a randomised block procedure to one of the following arms: placebo; On Day 7, the primary outcomes were serious adverse drug reactions and a rise in viral load. 32 participants were randomised to arm A, 29 to arm B, 32 to arm C, which was suspended on October 10th, 2021, with a dramatic decline in cases from 31 July 2020 to May 2021. Arm C, 2. 5 in arm B, and 2. 0 in arm A, with no significant differences between the two teams. Mean log 10 viral load reduction was 2. 9 in arm C, 2. 5 in arm B, and 2. 0 in arm B and 2. 0 in arm A, with no significant differences compared.

Source link: https://zenodo.org/record/6343896


Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities The I-TECH Randomized Clinical Trial

Objective Objectives of Studying the effectiveness of ivermectin in preventing the development of acute disease in high-risk patients with COVID-19. Participants of the Ivermectin Treatment Efficacy in COVID-19 High-Risk Patients study in Malaysia between May 31 and October 25, 2021, was an open-label randomized clinical trial conducted at 20 public hospitals and a COVID-19 quarantine center in Malaysia between May 31 and 2021. Outcomes and Measures The percentage of patients who progressed to severe disease was the proportion of patients who died from acute disease, which was defined as the hypoxic stage requiring additional oxygen to maintain pulse oximetry oxygen saturation of 95% or higher. Conclusions and Relevance In this randomized clinical trial of high-risk patients with mild to moderate COVID-19, ivermectin therapy during early illness did not prevent progression to severe disease in the patients. The study findings do not support the use of ivermectin in patients with COVID-19.

Source link: https://zenodo.org/record/6151791


Comparison of the Separate and Combined Effects of Physiotherapy Treatment and Corticosteroid Injection on the Range of Motion and Pain in Nontraumatic Rotator Cuff Tear: A Randomized Controlled Trial

We wanted to compare the effects of physiotherapy and corticosteroid injections on the performance, pain, and range of motion in patients with complete rotator cuff tears separated and simultaneously. The first group underwent 12 sessions of physiotherapy twice a week for six weeks; the second group received 80 mg of methylprednisolone and 1 ml of lidocaine 2%; and the third group received 80 mg of methylprednisolone and 1 ml of lidocaine 2%; and the third group received 80 mg of methylprednisolone and 1 ml of lidocaine 2%; and the third group received 60 physiotherapy session physiotherapy twice physiotherapy twice physiotherapy; the first group; the first group received 80 mg of lido physiotherapy; and 1 physiotherapy, 21 days; and 1 2%; and 1 2%; and 1 2%; and 1 2%; and 1 2%; and 1 2%; and 1 2%; and 1 2% in two days physiotherapy; and 1 2%; and 1 2% in two 2%; and 1 2%; and 1 2%; and 1 2%; and 1 2%; and 1 2%; and 1 2%; and 1 2%; and 4. 78, 52. 37, 77. 61, and 56. 4 million respectively; 5. 61, respectively; 5. 68, respectively; 51. 78, 52. 37, 56. 7, and physiotherapy + steroid groups; 5. 76, 5. 60; and 50. 78; respectively. The combination of physiotherapy and steroid therapy was more effective in lowering VAS and DASH scores than either physiotherapy or steroid injection alone.

Source link: https://zenodo.org/record/6048821


A new approach to assessing blinding for transcranial direct current stimulation treatment in patients with fibromyalgia. A randomized clinical trial

The most commonly used statistical tools for estimating blinding effectiveness are blinding indexes in Jamesu2019 and Bangu2019. Participants and therapist after experimental fibromyalgia after transcranial direct current stimulation. After the last session, both the therapist and patients were given a questionnaire to record which treatment had been administered, which was completed. Patients had 0. 83 for the patients and 0. 55 for the therapist, and the therapist had 0. 55. For the active and sham transcranial direct current stimulation groups, respectively, Bangu2019s BI for subjects was between -0. 08 and -0. 8. According to a therapist's BI, the therapist's active and sham transcranial direct current stimulation groups had 0. 21 and 0. 13 respectively. In this research, the therapist and patients with fibromyalgia have shown acceptable blinding of both the therapist and subjects with fibromyalgia.

Source link: https://zenodo.org/record/5495511


Efficacy and safety of the combination nifuratel-nystatin and clindamycin-clotrimazole, in the treatment of bacterial vaginosis. Randomized controlled clinical trial

The aim of this research is to determine the efficacy and safety of the combination nifuratel-nystatin and clindamycinclotrimazole in the treatment of bacterial vaginosis. According to the Amsel clinical standards and the Nugent score, randomized controlled clinical trials in 147 single women, non-pregnant and sexually ill, with a diagnosis of BV between 2016 and 2018, between 2016 and 2018. 73 people were randomized into two groups: nifuratel - nystatin and "B" - all three groups were divided into two groups: "A" 73 participants: nifuratel - nystatin and "B"; both groups were divided into two groups: "A" 73 women were divided into two groups: nystatin and "B"; nifuratel - nystatin and ny ovules The clinical cure rate with the nifuratelnystatin combination was 93. 1 percent, and that of clindamycin-clotrimazole 97. 2 percent was 92. 9 percent. The nifuratel-nystatin combination had an 87. 67% cure rate, but not clindamycin-clotrimazole 93. 2 percent, a 97 percent. "A" group recurrence was 12. 32% to 6. 7 percent in group "B" group ""B" compared to 7. 5% in group "B" 0".

Source link: https://zenodo.org/record/5075462


Protocol for a process evaluation of a cluster randomised controlled trial to improve psychosocial treatment of patients with psychotic spectrum disorders: the IMPULSE trial

This paper describes the process of a process evaluation of a cluster randomised controlled trial designed to determine the cost-effectiveness, and introduction of a digital mental health intervention, DIALOG+, in five Southeast European countries. a to investigate patients’ and clinicians' adherence; b to assess intervention fidelity; and c to investigate patients’ and clinicians’ a retrospective i. e. The United Kingdom Medical Research Council's guidance on process evaluations of complex interventions. This work is part of a larger study on the implementation of an affordable and cost-effective treatment for patients with psychotic disorders in low and middle-income countries in Southeast Europe; IMPULSE. Process evaluation findings will be used to interpret the trial findings, as well as assessing the impact of context on outcomes.

Source link: https://zenodo.org/record/4899502


Review of Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial

The two experimental groups were closely related, but the treatment group's O2 saturation was greater than that for the normal care group. How can these assertions by the main claim further to the COVID-19 pandemic? Much of the literature has focused on later stages of COVID-19 disease progression, but there are few studies on immunogenics for treating mild COVID-19 [2,3]. However, this report found that there are a decrease in urgent care, ED, or hospital visits, as well as a shorter recovery time from COVID-19. Budesonide is also a well-tolerated, ubiquitous, and cheap drug that could relieve symptoms and reduce patient escalation among COVID-19 patients if taken over a median of 7 days. It's also worth noting in the early stages of the COVID-19 disease course, but there's apprehension that giving steroids early in treatment could delay the immune system from properly responding. A randomised controlled trial conducted in Inhaled budesonide in the treatment of early COVID-19 disease. doi:10. 1101/2021. 21251134 [2] The WHO Rapid Evidence Appraisal for COVID-19 Therapies Working Group, published online January 1, 2021:2021. 04. 21141134. doi:10. 1101/2021. 02. 01. 21251134 [2] The WHO Rapid Evidence Appraisal for COVID-19 Therapies Working Group was published online on January 1, 2021. 02. 04. 21141134. doi:10. 1101/2021. 02. 01. 2024. 1131134. doi: A Meta-analysis of Systemic Corticosteroids and Mortality in Among Critically Ill Patients With COVID-19: A Meta-analysis. Covid-19 - Preliminary Report. Dexamethasone in Hospitalized Patients with Covid-19 -U2014 Preliminary Report.

Source link: https://zenodo.org/record/4663312

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions