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Treatment Trial - DOAJ

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Last Updated: 06 July 2022

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The quality of life in neoadjuvant versus adjuvant therapy of esophageal cancer treatment trial (QUINTETT): Randomized parallel clinical superiority trial

Abstract Background We investigated the quality of life in patients undergoing trimodality therapy for resectable stage Ir2010III esophageal cancer in patients. Methods Anesthesia A total of 96 patients was randomized to standard neoadjuvant cisplatin and 5u2010fluorouracil chemotherapy plus radiotherapy, surgical resection or adjuvant cisplatin, 5u2010fluorouracil, and epiplatin chemotherapy with concurrent extended volume radiotherapy following surgical resection. Conclusions The functional evaluation of cancer therapy:u2010esophageal total scores between arms at 1 year and 41% versus 41% versus 41%, respectively, indicated an increase of u226515 points relative to pre-u2010treatment, with no significant difference between arms. Compared to only 14% in the adjuvant arm, half of patients was able to complete the prescribed neoadjuvant arm chemotherapy without modification, compared to only 14% in the adjuvant arm. However, whether it is administered before or after surgery, trimodality therapy is challenging for patients with resectable esophageal cancer.

Source link: https://doi.org/10.1111/1759-7714.14433


Club Cell Secretory Protein–Derived Acute Respiratory Distress Syndrome Phenotypes Predict 90-Day Mortality: A Reanalysis of the Fluids and Catheter Treatment Trial

The cell secretory protein in Club cells is a protein that may be useful as a lung-specific biomarker for acute respiratory distress syndrome. In our subgroup of FACTT patients, the aim of this study was to characterize CC16 in plasma from patients enrolled in the Fluid and Catheter Treatment Trial to determine the prognostic value for patient outcomes. Plasma samples from 68 FACTT patients and 20 healthy controls were obtained from plasma samples from 68 FACTT subjects and 20 healthy controls. With an optimal cutoff value of 45 ng/mL, AUROC's analysis of CC16 showed an area under the ROC curve of 0. 78 for prediction of mortality with an optimal cutoff value of 45 ng/mL. Patients in the low CC16 cohort had lower mortality and a similar VFD. With a cut point of 45 ng/mL, the CC16 developed an acceptable AUROC for patient mortality prediction with a cut point of 45 ng/mL. Patients with elevated CC16 on day 1 had poorer outcomes compared to those with low CC16, indicating a prognostic role for this lung-specific biomarker.

Source link: https://doi.org/10.1097/CCE.0000000000000711


Adapting Peer Researcher Facilitated Strategies to Recruit People Receiving Mental Health Services to a Tobacco Treatment Trial

IntroductionIt's one of the most difficult aspects of conducting intervention trials among people with severe mental illness and those who smoke cigarettes is recruitment. The aim of this research was to: describe adaptive peer researcher-facilitated recruitment methods; investigate the effectiveness of these policies; investigate whether recruitment tactics were targeted to particular subgroups of participants; and determine the costs and resources required for implementing these strategies. Now, we provide experience-based lessons in a Peer Researcher Commentary. MethodsPeople were included in the RCT if they smoked at least 10 cigarettes a day and were receiving psychological health services from the project's two partnering mental health services in Victoria, Australia, who were receiving health services. Anywhere in Victoria, we began online recruitment in the final four months of the study, broadening it to people who smoked and needed medical assistance or treatment for mental health, alcohol, or other drug problems. The differences between recruiting tactics on key participant characteristics were determined. Participants recruited face to face were significantly more likely to be living in partially or fully supported independent living, reflecting our initial focus on supporting independent living. The most cost-effective and costly option for recruiting into a nicotine treatment trial was difficult and costly, according to the least. DiscussionPeer researcher, who facilitated recruitment into a tobacco treatment trial was difficult and costly.

Source link: https://doi.org/10.3389/fpsyt.2022.869169


P161 ROLES OF ANGIOPOIETINS 1 AND 2 ON ARTERIAL FUNCTION DURING A TREATMENT TRIAL IN PEOPLE WITH OR AT RISK OF DIABETES

We hypothesised that elevated circulating Ang1 and lower Ang2 could be responsible for increased arterial stiffness and trial shifts during the trial, independent of blood pressure. Vascular results were aortic pulse wave velocity, cardiac-ankle pulse wave speed, and aortic pulse wave rate, according to multiple regression models for baseline BP and u0394BP over six months. Baseline Ang1 was positively affected by increased baseline Ang2:1 ratio with aPWV, independent of BP, BMI, and DM status, so baseline r = 0. 3 for u0394aPWV over the trial. Ang1's baseline Ang1 predicted lower aoPWV by 6 months but not by the time. Angiopoietins were linked to baseline aPWV, independent of BP, and to u0394aPWV during the trial, which was also independent of BP change, but not connected to CAVI or BP.

Source link: https://doi.org/10.1016/j.artres.2017.10.182


Passive mobilisation of the shoulder in subacute stroke patients with persistent arm paresis: A randomised multiple treatment trial

Objects: A randomised multiple treatment trial was conducted to compare the effects of various mobilisation strategies on shoulder PROM. Method: Eleven people with upper limb paresis in the subacute phase were diagnosed with three separate mobilisation strategies, including combined soft-tissue mobilization in the scapular plane, scapular mobilization without glenohumeral movement, and angular mobilisation in the frontal plane, as described in the following video. Patients in the subacute phase of stroke with persistent arm paresis resulted in an elevated passive shoulder external rotation as a result of continuous arm paresis. Averaging gain of 6. 82 percent for shoulder external rotation was found, but passive external rotation decreased after the two other methods. These preliminary findings suggest that combined soft-tissue mobilization techniques could raise the PROM for external shoulder rotation in subacute stroke patients with persistent arm paresis. Clinical implications: A specific mobilisation technique may have positive results on shoulder PROM.

Source link: https://doi.org/10.4102/sajp.v78i1.1589


Duty, desire or indifference? A qualitative study of patient decisions about recruitment to an epilepsy treatment trial

Abstract Background Epilepsy is a common medical disorder in which drugs are the mainstay of treatment, and prescription trials are common. The findings may also have broader applicability; knowing why patients may or may not enroll in epilepsy drug trials is therefore of utmost importance, particularly at a time of rapid drug manufacturing and testing; and, the results can also have broader applicability. This report explored the role of patient involvement in the decision-making process surrounding the recruitment of an RCT that compared different antiepileptic drug therapies for the treatment of new-onset seizures and epilepsy. Methods In-depth interviews with 23 patients recruited from four research centers in-depth. Informants either viewed the trial as highly useful or unlikely to be harmful, and so declined to participate; or as potentially harmful or unlikely to be helpful, with no option being allowed to participate.

Source link: https://doi.org/10.1186/1745-6215-7-32


Comparison of multistate Markov modeling with contemporary outcomes in a reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial.

For the primary analysis in acute stroke therapy trials, ordinal measures of functional outcome have been dichotomized. In addition, a multistate Markov model that used an estimate of the unobservable baseline result from principal component analysis was used to re-analyze the National Institute of Neurological Diseases and Stroke's tissue plasminogen activator study, which showed a consistently high incidence of tissue plasminogen activator use in the analysis of the primary outcome 90 days post-stroke. Multistate Markov modeling allows for a more targeted assessment of treatment outcome and tracks the transition of modified Rankin Scale states over time, which may provide more clinical insight into the treatment effect. In describing treatment effect in acute stroke therapy trials, multistate Markov models are both feasible and desirable.

Source link: https://doi.org/10.1371/journal.pone.0187050


An open treatment trial of duloxetine in elderly patients with dysthymic disorder

Objective: We investigated the safety and side effects of the selective serotonin and norepinephrine reuptake inhibitor antidepressant duloxetine in older adults with dysthymic disorder. The main findings were compared from baseline to 12 weeks in Hamilton's 24-item Hamilton Depression Rating Scale scores and Treatment Emergent Symptom Scale ratings, respectively. Hamilton Depression Rating Scale u2264 6. u2265 percent decline in Hamilton Depression Rating Scale scores with a Clinical Global Impression of much improved or worse, and remission is required for final Hamilton Depression Rating Scale u2264 6. The mean final dose was 51 mg and correlated strongly with decline in Hamilton's Depression Rating Scale, according to the Hamilton Depression Rating Scale's decrease; Hamilton's Depression Rating Scale decline was highly associated with the decline in Treatment Emergent Symptoms Scale. Prior to duloxetine therapy, there were normal gastrointestinal side effects, but with duloxetine, they were more noticeable rather than worsened. In older patients with dysthymic disorder, a systematic placebo-controlled trial of duloxetine may be necessary.

Source link: https://doi.org/10.1177/2050312114533536


Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV‐Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial

Methods and Results We looked at cardiovascular risk factors in the START trial, a randomized analysis of immediate versus delayed ART initiation among HIV-positive individuals with CD4+ cell counts > 500 cells/mm3. Patients in the immediate ART group had elevated total cholesterol, low-u2010density lipoprotein cholesterol, and increased use of lipid lowering therapy compared to patients in the deferral group. With immediate ART, a 0. 1 decrease in total cholesterol to a high-u2010density lipoprotein ratio was seen. Conclusions Among HIV-1 billions of total cholesterol and low-u2010density lipoprotein cholesterol rises, as well as declines in blood pressure medications have contributed to rises in total cholesterol and low-u2010density lipoprotein cholesterol. "These competing findings show that early ART's net effect on traditional cardiovascular disease risk factors may be statistically insignificant in the short term. ".

Source link: https://doi.org/10.1161/JAHA.116.004987


Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial – BCPP/Ya Tsie trial

Methods: In the 30-community Ya Tsie trial in Botswana, we sought to establish the causes of HIV transmission in universal test-and-treat studies, gender, age, and randomized-HIV-input HIV-infected trials. From 5114 trial participants in 30 trial groups, we sequenced HIV viral whole genomes. Transmissions from control groups from control cultures were more prevalent than the reverse post-baseline than those from the reverse post-baseline than at a baseline, benefiting from treatment-as-prevention. Conclusions: Our results show that population mobility patterns are essential to HIV transmission dynamics and the effectiveness of HIV prevention efforts.

Source link: https://doi.org/10.7554/eLife.72657

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions