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Traumatic Brain Injury - Springer Nature

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Last Updated: 18 May 2022

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Racial and Ethnic Disparities Associated with Traumatic Brain Injury Across the Continuum of Care: a Narrative Review and Directions for Future Research

Background The cause of traumatic brain injury care is a growing body of evidence on racial and ethnic inequalities. Result Our editorial analysis of 39 journals revealed numerous ways in which racial and ethnic inequalities were present throughout the TBI continuum of care, including acute care and diagnosis, post-TBI recovery and adjustment, and long-term outcomes. Conclusions: Understanding racial and ethnic group differences is the first step in ensuring equitable treatment for all people with TBI, including raising concerns among physicians and facilitating the design of targeted interventions for racial and ethnic minority groups.

Source link: https://doi.org/10.1007/s40615-021-01017-4


Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis

Patients with isolated TBI in the early hours of injury were tested in patients with implanted TBI in the prospective multinational Collaborative Brain Injury Research, Traumatic Brain Injury Study. Patients with strictly isolated TBI were selected and stratified for coagulopathy by a national standardized ratio that has been widely used over time to establish trauma-related coagulopathy in general trauma populations.

Source link: https://doi.org/10.1007/s12028-021-01400-3


Tailored Therapeutic Doses of Dexmedetomidine in Evolving Neuroinflammation after Traumatic Brain Injury

Background is required for the development of new therapeutic approaches. Understanding the secondary injury mechanisms of traumatic brain injury is crucial for developing new therapeutic approaches. Neuroinflammation plays a crucial role in secondary brain injury after TBI. The discovery of NLRP3 inflammasome mediators is the product of a mystery, and, in addition, later in the reaction, microglial activation and migration of the peripheral immune cells into the injured brain are observed. Methods of Brain Injury Brain injury was caused by a weight-drop model. The mice were killed on the first or the third day after TBI and histopathologic and immunofluorescent findings of brain tissue were determined. Multiple comparisons were done by using the Kruskal–Wallis test, and the Mann–Whitney U -test was used to compare two groups. Both terms, low doses of Dex inhibited NLRP3 and interleukin-1 in both directions. In addition, in the late phase after TBI, high doses of Dex cause a dramatic decrease in the migration and motility of microglial cells and T cells. Interestingly, the immune cells were only influenced by high-dose Dex in the late stage of TBI, but it also improved neurologic outcomes in the same period. Different doses of Dex attenuate neuroinflammation in the mice's head trauma model by suppressing specific aspects of the neuroinflammatory process in a different timeframe that aids in neurologic recovery. These findings show that Dex may be a safe option for sedation and analgesia in patients with TBI.

Source link: https://doi.org/10.1007/s12028-021-01381-3


Modeling Brain–Heart Crosstalk Information in Patients with Traumatic Brain Injury

Background: Traumatic brain injury is a highly variable and complex pathology that requires the integration of several physiological parameters to facilitate optimal diagnosis and clinical care of patients. Data collected from intracranial pressure monitoring can be combined with findings from heart rate monitoring to determine the interplay between brain and heart. Methods We created a new measure of brain–heart interplay in our previous research, as well as two additional brain–heart crosstalks indicators [mutual information and average edge overlap] generated from a complicated network model of the brain–heart system. As part of the Collaborative European Neurotrauma Effectiveness Research in TBI high-resolution work package, we investigated the relationship of these novel indicators with respect to mortality in a multicenter TBI cohort. TBI patients were included in this study in a total of 226 patients. The Kruskal-Wallis test, which measures of survivors and nonsurvivors of brain–heart crosstalks measurements of survivors and nonsurvivors, revealed statistically significant differences between the two groups. To properly cope with the age confounding factor, the prediction models were created by dividing the original cohort into four age groups. The presence of an inverse correlation between brain-heart crosstalks and mortality was also confirmed. Conclusions The existence of a negative correlation between mortality and brain–heart crosstalks results shows that a healthy brain–cardiovascular interaction plays a role in TBI.

Source link: https://doi.org/10.1007/s12028-021-01353-7


Non-Linear Device Head Coupling and Temporal Delays in Large Animal Acceleration Models of Traumatic Brain Injury

Head kinematics analysis after an external blow is an essential component of traumatic brain injury research. Rather than performing direct measurement, the majority of recent large animal studies have suggested an analogous relationship between the device delivering the impulsive load and subsequent head kinematics. In an acceleration TBI model, the current research investigated factors that influence device/head coupling kinematics. According to Experiment 1, there has been a 50% decrease in peak angular velocity for swine head relative to the device, with a doubling in temporal duration.

Source link: https://doi.org/10.1007/s10439-022-02953-w


Correlation of Cerebral and Subcutaneous Glycerol in Severe Traumatic Brain Injury and Association with Tissue Damage

Background This paper is a subset of a prospective double-blinded randomized trial investigating the role of prostacyclin in severe traumatic brain injury. Patients with sTBI aged 15 to 70 years were given a Glasgow Coma Scale Score, 8 of whom were included. Brain tissue damage was also assessed by using the Rotterdam classification of brain computed tomography scans and the biochemical biomarkers S-100B and NSE. Patients with a positive correlation of glycerol_brain/sc had marginally higher brain glycerol levels compared to those with no correlation. Conclusions We've found that peripheral glycerol can flow into the brain.

Source link: https://doi.org/10.1007/s12028-021-01412-z


Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences?

Background In the traumatic brain injury case, large between-center variations in diagnosis and outcome for patients managed in the intensive care unit have been shown. This research is designed to see if European neurotrauma centers can be clustered based on their treatment preference in various areas of TBI care in the ICU. Heat maps were used to determine whether hospitals could be organized to find particular hospitals that are adhere to particular treatment plans. Conclusions Although there were similarities between treatment plans within domains were found, the inability to cluster hospitals showed that a narrow treatment choice within a domain is not a substitute for other treatment options within or outside the domain. These findings show that investigating the effects of specific TBI interventions on outcomes can be based on between-center variation, rather than being significantly confounded by other therapies. Trial registration We do not announce the findings of a health-care intervention.

Source link: https://doi.org/10.1007/s12028-021-01386-y


Palliative Care Consultations in Patients with Severe Traumatic Brain Injury: Who Receives Palliative Care Consultations and What Does that Mean for Utilization?

Palliative care has the potential to enhance goal-conservant care in the case of traumatic brain injury. Secondary goals were to investigate PCE usage over time and compare health care resources between patients with or without PCEs. Results From 2001 to 2015, the proportion of palliative care use in patients with sTBI increased by 46. 6 percent, 22. 3% Black, and 25% Hispanic patients with sTBI had a palliative care consultation in 2015. Patients receiving a PCE resulted in a lower rate of PEG tube placement; however, White patients had a greater reduction of PEG tube placement than Black patients. Patients in palliative care had lower total hospital expenses than others in general hospitalization.

Source link: https://doi.org/10.1007/s12028-021-01366-2


Lower cortical volume is associated with poor sleep quality after traumatic brain injury

Traumatic brain injury has been attributed to poor sleep, according to studies. Using the Pittsburgh Sleep Quality Index, subjective sleep quality was assessed. The association of PSQI and cortical volume in grey matter and white matter voxels was used to create statistical maps of the relationship between PSQI and cortical volume in gray matter and white matter voxels, according to Voxel Based Morphometry. Higher PSQI total scores were directly related to reduced gray matter volume in the cerebellum, according to the cerebellum. Poor sleep quality after TBI is clearly linked to reduced cerebellar volume, according to our results, with trending patterns in regions associated with inhibitory function.

Source link: https://doi.org/10.1007/s11682-021-00615-4


Participant factors that contribute to magnetic resonance imaging motion artifacts in children with mild traumatic brain injury or orthopedic injury

This report examined qualitative and quantitative approaches to motion artifacts detection and correction, as well as whether motion artifacts detection and correction can be related to injury prevention, age, or sex in children with mild traumatic brain injury or orthopedic injury in comparison to typical developing children. Children aged 8 to 16 years with mild traumatic brain injury or orthopedic injury were recruited from the emergency service and undertook an MRI scan less than two weeks post-injury. Both T1- and diffusion-weighted photos had significant correlations with motion artifacts. Children with mild traumatic brain or orthopedic injury suffered significantly more motion-corrupted diffusion-weighted volumes than typical growing children, but minor traumatic brain injury and orthopedic injury groups did not differ from each other. Results have ramifications for structural MRI studies and show the importance of considering motion artifacts in studies of pediatric mild traumatic brain injury.

Source link: https://doi.org/10.1007/s11682-021-00582-w

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions