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Traumatic Brain Injury - PubMed

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Last Updated: 18 May 2022

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circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury.

Circular RNAs are abundant in the brain and contribute to central nervous system diseases, but specific roles of circRNAs in human traumatic brain injury have yet to be established. Further research revealed that circHtra1 acts as a miR-3960 sponge and raises the expression of GRB10, which is involved in TBI infiltration after TBI. Since brain insults restricted the circulation of circHtra1, decreased the expression of ADAR1 after brain insults upregulated the human race. Our findings show that circHtra1 contributes neuronal damage by sponging miR-3960 and regulating GRB10 and apoptosis during brain insults. In addition, A-to-I editing could help control circRNA expression profiles after TBI, and circHtra1 is a potential therapeutic target.

Source link: https://doi.org/10.1155/2022/3522492


Electrophysiological correlates of thalamocortical function in acute severe traumatic brain injury.

Tools for determining recovery after acute critical brain injury can be aided in monitoring. The ABCD framework divides resting-state EEG into categories based on factors of thalamocortical network function that are linked to success in post-cardiac arrest coma. In this longitudinal cohort analysis, we applied the ABCD framework to 20 patients with acute traumatic brain injury requiring intensive care and 16 healthy controls. In the proportion of different channel-level ABCD classifications, 95% of patients displayed 'D' signals on at least one channel, but within-session temporal variation and spatial heterogeneity in the proportion of different channel-level ABCD classifications emerged. Patients with and without command-following in the subacute-to-chronic phase of recovery, according to p. . 01.

Source link: https://doi.org/10.1016/j.cortex.2022.04.007


Use of Hyperoncotic Human Albumin Solution in Severe Traumatic Brain Injury Revisited-A Narrative Review and Meta-Analysis.

Patients with a severe traumatic brain injury have hypoalbuminemia and necessitate fluid resuscitation. Low serum albumin levels in non-brain injured intensive care units and in perioperative patients are eliminated by fluid resuscitation with human albumin. The infusion of hypooncotic HAS in patients with TBI was associated with adverse outcomes in patients with TBI. Further investigation is needed into the Lund model of TBI therapy's side effects, as well as the safety and effectiveness of hyperoncotic HAS. 24 people died vs. 59 out of 155 control patients among 165 patients treated with hyperoncotic HAS, according to the Lund model. Patients with TBI are at a high risk of bias for fluid administration with hyperoncotic HAS. Prospective randomized controlled trials are required, which may lead to changes in clinical guidelines for fluid management in patients with TBI.

Source link: https://doi.org/10.3390/jcm11092662


Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset.

Age is a risk factor for a slew of adverse outcomes following traumatic brain injury, with some reports indicating that age is also a cause of excess disability. More than 20 years post injury, we investigated the extent to which age moderates the effects of injury severity on functional trajectories over 15 years. The results from 11,442 participants from the 2020 National Institute of Disability and Independent Living Rehabiation Research Traumatic Brain Injury Model Systems National Dataset were analyzed using linear mixed effects models. Those with mild TBI had the highest incidence. Age should also be a significant point in TBI research.

Source link: https://doi.org/10.3390/jcm11092477


A Calixarene Assembly Strategy of Combined Anti-Neuroinflammation and Drug Delivery Functions for Traumatic Brain Injury Therapy.

Excessive inflammation response promotes brain injury and delays the recovery of neural function in nervous system disorders. In vitro and in vivo, we reviewed a series of calixarenes and found that among them, the self-assembling architecture of amphiphilic sulfonatocalix[8] rene had the most potent ability to prevent neuroinflammation. In addition, we discovered that SC8A12C assemblies penetrated into the brain parenchyma and eliminated the inflammatory factor storm, thus restoring neurobiological function in a mouse model of traumatic brain injury.

Source link: https://doi.org/10.3390/molecules27092967


Nano-PSO Administration Attenuates Cognitive and Neuronal Deficits Resulting from Traumatic Brain Injury.

Traumatic Brain Injury (TBI) is one of the most common causes of neurological damage in young populations. In mice models of AD and genetic Creutzfeldt Jacob disease, a Pomegranate seed oil [Nano-PSO] formulation has been shown to target the brain and later reduce memory loss and neuronal death. We find that administering Nano-PSO to mice before or after TBI application has minimized cognitive and behavioral decline, which is shown in this article. SIRT1 and SYP protein postinjury were both elevated as a result of Nano-PSO intake.

Source link: https://doi.org/10.3390/molecules27092725


Caregiver Characteristics of Adults with Acute Traumatic Brain Injury in the United States and Latin America.

Objectives: To determine the characteristics of caregivers of adults with acute traumatic brain injury in the United States and Latin America. In the United States, English-speaking caregivers of adults with TBI are included in Cohort 1: Adults with TBI are among adults with TBI in English-speaking caregivers of adults with TBI. Cohort 2: Adults with TBI in Mexico or Colombia with Spanish-speaking caregivers. Differences between U. S. and Latin American caregivers were: age; occupation status; violent-related etiology; and the occurrence of depressive disorders. TBI caregivers in the United States were older and employed full-time or retired more often than those in Latin America. Conclusions: TBI caregivers in the United States were older and retired full-time or retired more often than those in Latin America.

Source link: https://doi.org/10.3390/ijerph19095717


Effects of Traumatic Brain Injury on the Gut Microbiota Composition and Serum Amino Acid Profile in Rats.

Traumatic brain injury has a major effect on the body: it affects the brain and the peripheral nervous system, as well as shifts homeostasis in several types of tissue. An acute brain injury compromises the "brain-gut microbiome axis," a well-balanced network of the brain, gastrointestinal tract, and gut microbiome, which has a variable effect: injury to the brain changes the microbiome's microbiome; the altered microbiome changes TBI severity, neuroplasticity, and metabolic pathways through a variety of bacterial species; and metabolic pathways by various bacterial metabolites. There were no significant associations between TBI severity and the pre-existing gut microbiota composition or blood metabolites.

Source link: https://doi.org/10.3390/cells11091409


Immunomodulatory protein from ganoderma microsporum protects against oxidative damages and cognitive impairments after traumatic brain injury.

Immunomodulatory protein from Ganoderma microsporum inhibits oxidative stress in lung cancer cells A549 and promotes cancer cell death by intracellular autophagy, according to studies. Thus, this review investigated whether GMI could be used to prevent or treat TBI by its anti-inflammatory and antioxidative properties. In a vivo model of TBI, we used glutamate-induced excitotoxicity as in vitro model and penetrating brain injury. GMI inhibits intracellular reactive oxygen species formation and reduces neuronal death in cortical neurons against glutamate excitotoxicity, according to the authors. In neurite injury case assay, GMI promotes neurite regeneration, and GMI promotes neurite regeneration, the regenerated neurite's length was much longer than that of the control group. It's the first study to apply GMI to brain-injured diseases, and it confirms that GMI reduces oxidative stress caused by TBI and improves cognitive function.

Source link: https://doi.org/10.1016/j.mcn.2022.103735


Transcriptional Profiling in a Novel Swine Model of Traumatic Brain Injury.

Transcriptomic studies of traumatic brain injury can reveal a wealth of information about post-injury processes. However, a large animal model of TBI has a greater resemblance to human TBI in terms of anatomical structure, mechanics of injury, genetics, and, perhaps, molecular response. After TBI, we investigated gene expression differences between injured and uninjured sides of pig cerebral cortex after TBI, in light of the benefits of a large animal TBI model. Given the acute inflammation following TBI and the critical role that immune response plays in neuroplasticity and recovery, we predicted that transcriptional changes involving immune function will be upregulated. Pericletusional cortex tissues from the injured side of the injured side and contralateral cortical tissue were collected at 24 h after TBI. At an acute time point after TBI in pigs, this research reported some of the key transcriptional changes in the perceptive and contralateral tissue at an acute time point.

Source link: https://doi.org/10.1089/neur.2021.0051

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions