Advanced searches left 3/3

Traumatic Brain Injury - Crossref

Summarized by Plex Scholar
Last Updated: 18 May 2022

* If you want to update the article please login/register

Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway

Abstract: Traumatic brain injury is the most common cause of death and permanent disability globally. Human umbilical cord mesenchymal stem cells can be helpful in neurological recovery after TBI, according to increasing evidence. However, the risk of tumorigenicity, psychological uncertainty, ethical concerns, and the possibility of tumorigenicity have all limited the clinical use of HUCMSCs transplantation in TBI. Many studies have found that exosomes from HUCMSCs may be a promising alternative to transplantation of HUCMSCs. After TBI, we found that exosomes derived from HUCMSCs significantly enhanced sensorimotor function and spatial learning in rats.

Source link: https://doi.org/10.1515/biol-2022-0022


Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive function

Background information: Persistent neuroinflammation and mitochondrial dysfunction in brain energy metabolism is typical in acute brain injury cases. Here we concentrated our review on the use of EE in regulating injury-induced neuroinflammation and energy metabolism in the prefrontal cortex and hippocampus due to a lack of success of most TBI interventions and the documented benefits of environmental enrichment in improving brain plasticity. Adult male Wistar rats were included in the study and randomly selected to receive either: mild TBI using the medical injury model or sham surgery, or sham surgery. After mTBI, decreased the pro-inflammatory cytokines IL-1 and TNF-, as well as elevated levels of the anti-inflammatory cytokine IL-10; reduced mTBI-induced cognitive impairment; and attenuated mTBI-induced decline in pAMPK/AMPK ratio and uMtCK ratios and uMtCK ratios and uMtCK ratio and uMtCK ratios; and TNF-those Conclusions Our results showed that EE could influence the persistent: neuroinflammatory response seen after mTBI, as well as persistent changes in brain energy homeostasis.

Source link: https://doi.org/10.1186/2051-5960-1-57


A Bayesian MultiLayer Record Linkage Procedure to Analyze PostAcute Care Recovery of Patients with Traumatic Brain Injury

Summary: Understanding the links between injury severity and post-acute care recovery for patients with traumatic brain injury is vital to improving care. In the absence of unique identifiers, record linking techniques identify patient data sets that match the same patient across data sets. Patients are a natural grouping scheme for patients, because only records that have been treated by the same provider can identify the same patient. To determine the relationship between TBI patients' injury severity and post-acute care recovery, we use this method to blend a trauma registry with Medicare claims.

Source link: https://doi.org/10.1093/biostatistics/kxac016


Evidence of traumatic brain injury in headbutting bovids

Abstract based on trauma related brain injury and death that is still poorly understood. Traumatic brain injury is a leading cause of neurologic impairment and death that is not fully understood. We investigated the risk of brain injury after headbutting in two combative bovid species by looking at neuromorphology and neuropathology by immunohistochemistry and stereological quantification. High-resolution MRI and processed histologically for signs of TBI in muskoxen and bighorn sheep. Phosphorylated tau protein, a TBI biomarker present in cerebrospinal fluid and in neurodegenerative lesions, was used to determine future cellular consequences of chronic or acute TBI. In the bighorn sheep, Tau-immunoreactive lesions were unusual. In addition, microglia and astrocytes showed no clustering around tau-immunoreactive cells in either species. Our preliminary findings show that muskoxen and other headbutting bovids suffer from persistent or acute brain injury, and that the males' thicker skulls can shield them to a certain degree.

Source link: https://doi.org/10.1007/s00401-022-02427-2


Otorhinolaryngological manifestations in Traumatic brain injury in a tertiary care center of western Nepal

Introduction: Otorhinolaryngological injuries in head injury are something that are extremely common, but yet are often ignored, missed, and even forgotten at times. In cases of head injury in a tertiary care center in western Nepal, we investigated the epidemiological, epidemiological findings, clinical reports, and management of these related injuries in cases of head injuries. Conclusions: Soft Tissue lacerations were the most common findings in all head injuries; nose and face lacerations, nose and face lacerations, and facial bone fractures were the typical findings. Patients with mild head injury, 23 cases with moderate head injury, and 17 cases with significant head injury in patients with ENT findings were among those referring to ENT findings. There was no statistically significant difference between the head injuries with and without ENT manifestations or respectively, according to them.

Source link: https://doi.org/10.3126/jbsfn.v2i2.45116


Nutritional Support for Pediatric Severe Traumatic Brain Injury

Diete can help with optimal recovery in critically ill children with severe traumatic brain injury. Nutritional therapy in the pediatric intensive care unit is also on the forefront of ongoing studies. Children with sTBI experience dynamic physiologic derangements in the acute post-injury period that may alter metabolic demand, resulting in nutritional requirements that may differ from those in other critically ill patients. Currently, there are relatively few studies examining diet habits in PICU patients, as well as those that focus on pediatric sTBI patients. According to available reports, modern neurocritical care regimens may well reduce the expected hypermetabolic state following sTBI, and that early enteral intake may be associated with reduced morbidity and mortality. We will summarize available evidence on diet therapy for children with sTBI and identify research gaps in the future.

Source link: https://doi.org/10.3389/fped.2022.904654


Correlation of Cerebral and Subcutaneous Glycerol in Severe Traumatic Brain Injury and Association with Tissue Damage

The aim of the present study was to determine whether there was a correlation between brain and subcutaneous glycerol levels and whether the ratio of interstitial glycerol in the brain and subcutaneous tissue was related to tissue damage in the brain, as determined by using the Rotterdam score, S-100B, neuron-specific enolase, the Acute Physiology and Chronic Health Evaluation Score, and trauma type. Patients with sTBI aged 15 to 70 years were assessed using a Glasgow Coma Scale Score ( 8 were included). Brain tissue damage was also assessed by using the Rotterdam classification of brain computed tomography scans and the biochemical biomarkers S-100B and NSE. Patients with a positive correlation of glycerol brain/sc had marginally elevated brain glycerol levels relative to those with no correlation.

Source link: https://doi.org/10.1007/s12028-021-01412-z


Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis

Patients with isolated TBI in the early hours of injury were tested in patients with acute coagulation assays, which was embedded in the ongoing multinational Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury. Patients with INR 1. 2 had a high risk of chronic intracranial hemorrhage, increased mortality, and unfavorable outcomes, compared to patients with INR 1. 2.

Source link: https://doi.org/10.1007/s12028-021-01400-3


Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences?

Abstract Background In the aftermath of a catastrophic brain injury, large between-center differences in diagnosis and outcomes for patients treated in the intensive care unit have been shown. The aim of this research is to determine if European neurotrauma centers can be clustered based on their treatment preference in different areas of TBI care in the ICU. Methods of care centers participating in the Collaborative European Neurotrauma Effectiveness Research in TBI's study were used to determine correlations within and between the predefined domains: intracranial pressure monitoring, coagulation and transfusion, epiphylactic antibiotics, and more general ICU treatment guidelines. Conclusions Although correlations between treatment policies within domains were established, the failure to cluster hospitals shows that a narrow treatment option within a domain is not a proxy for other treatment choices within or outside the domain.

Source link: https://doi.org/10.1007/s12028-021-01386-y

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions