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Purpose: Objectives: To review the evidence for changes in choroidal thickness and choroidal vascularity index in people with thyroid eye disease, as determined by severity, as determined by optical coherence tomography. Result Nineteen studies were included in the publication that contained data from 1067 eyes in 798 patients with TED. Patients with TED had elevated CVI and increased choroidal thickness, particularly in the subfoveal region, according to the majority of studies. Conclusions This systematic review found a connection between elevated CVI/choroidal thickness and TED, pointing to a possibility for OCT-measured CVI/choroidal thickness as an objective clinical measure.
Source link: https://europepmc.org/article/MED/36437586
Teprotumab, a monoclonal antibody that blocks the insulin-like growth factor 1 receptor, is the first disease-modifying therapy approved in the United States for the treatment of thyroid eye disease. Intrvenous teprotumumab greatly improved proptosis response rate and a variety of other TED outcomes, including overall response rate, Clinical Activity Score, diplopia, and disease-specific quality of life in adults with active, moderate-to-severe TED. Teprotumab may also be helpful in a more diverse TED population, according to a real-world experience.
Source link: https://europepmc.org/article/MED/36418673
Objectives: To report the results of strabismus surgery in thyroid eye disease using intraoperative bow-knot adjustable sutures under topical anaesthesia and calculate prediction models for surgical correction and postoperative drift depending on surgical dose response. As a fair result, subjective diplopia corrected with prisms within acceptable motor alignment was considered a fair result. Mean preoperative horizontal and vertical deviations were 26. 9 PD and 11. 8 PD, respectively. Mean horizontal drift was 3. 2 PD, whereas mean vertical drift was 3. 4 PD. For each medial rectus recession and 3. 75 PD/mm for unilateral inferior rectus recession, a linear regression developed a dose-response of 2. 37 PD/mm. Conclusions Muscle resorption with intraoperative adjustable sutures is highly effective for the treatment of thyroid eye disease strabismus. The first postoperative target of choice should be Undercorrection proportional to the planned surgical dose.
Source link: https://europepmc.org/article/MED/36402196
Background: Thyroid eye disease is an extrathyroidal manifestation of Graves-u2019 disease and is associated with dry eye disease. This is the first systematic review and meta-analysis to determine the role of magnetic resonance imaging lacrimal gland parameters in TED diagnosis, activity grading, and therapeutic responses prediction. The main outcome measures include seven structural MRI parameters and three functional MRI parameters. LG's spatial and functional parameters could be used to diagnose TED; LGH, MCA, and DWI-ADC for differentiating active from inactive TED; and DTI parameters and LGH for assisting in grading and therapeutic responses prediction respectively; Conclusions: MRI LG lab parameters can detect active TED and distinguish TED from controls. The most useful indicator for TED diagnosis and activity grading is MCA. Diagnostic superiority has been demonstrated by inconclusive findings that show whether structural or functional LG parameters have diagnostic validity. Future studies are highly recommended to determine the use of MRI LG parameters in TED.
Source link: https://europepmc.org/article/PPR/PPR572678
Purpose: Objective Objectives: To determine the connection between thyroid eye disease and glaucoma, the link between thyroid eye disease and glaucoma can be determined. In a 1:4 ratio, those with TED-related diseases were identified and compared with 2020 Census-matched controls without a diagnosis of TED in a 1:4 ratio. The authors used Pearson's u03c72 experiments to collect demographics by TED status, logistic regression to produce odds ratios and 95% confidence intervals to determine the association between TED and glaucoma, using those without TED as the reference group. Overall, 114 of TED cases had a diagnosis of glaucoma, compared to 94 of non-TED controls. On bivariate logistic regression models, those diagnosed with TED were significantly more likely to be diagnosed with glaucoma than with controls. Individuals with TED were significantly more likely to be diagnosed with glaucoma than those without retining. Clinicians treating patients with TED should be aware of this increased risk and arrange glaucoma testing as appropriate.
Source link: https://europepmc.org/article/MED/36394556
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