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Thyroid Eye Disease - DOAJ

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Last Updated: 05 January 2023

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Traumatic Orbital Floor Fracture Causing Therapeutic Orbital Decompression in Thyroid Eye Disease

A CT scan in the emergency room revealed a left orbital floor fracture and decompression of the left orbit. Although nonsurgical orbital decompression has been implicated in several cases, spontaneous ethmoid bone remodeling or fracture has been the most cited mechanism, in rare cases of true spontaneous orbital floor fracture, with rarer instances of true spontaneous orbital floor fracture. In addition, there are only two reported cases of traumatic orbital floor fractures with subsequent orbital decompression in the context of thyroid eye disease.

Source link: https://doi.org/10.1159/000528423


Adjunctive Middle Turbinectomy for Endoscopic Medial Orbital Wall – Thyroid Eye Disease Decompression

Introduction Middle turbinate resection is often done during endoscopic sinus and skull base surgery. Objective : The aim of this research was to determine the additional orbital soft tissue volume increase during endoscopic medial wall decompression with adjunctive MTR. Methods A retrospective review of patients who underwent endoscopic medial wall decompression with MTR was conducted. In the ethmoid bed, the imaging software AW was used to display pre- and postoperative orbital computed tomography images to map the preoperative position of the middle turbinate and the postoperative orbital soft tissue. After medial wall decompression, the decompression of orbital soft tissue was found in this patient cohort and adjunctive middle turbinate resection for endoscopic medial orbital wall decompression added u223c 0. 83 cc of volume for orbital soft tissue. Middle turbinate resection is a valuable adjunct to the orbital surgeon's armamentarium to improve the results of a selective patient's medial orbital decompression.

Source link: https://doi.org/10.1055/s-0041-1740156


The correlation of the neutrophil–lymphocyte ratio to clinical and imaging parameters in patients with thyroid eye disease

Graves:u2019 disease is the most common extrathyroid condition of Graves'u2019 disease. From MR images, the mean signa l intensity ratio, average extraocular muscle diameter, and proptosis of the study eye were determined. Patients with NLR 22. 0 were older, had a higher CAS, average SIR, average EOM diameter, and proptosis, and had a lower serum thyrotrop hin receptor antibody level than patients with NLR 2. 0. At a median follow-up of 25 months, a high NLR at baseline revealed that a high NLR at baseline was correlated with a poor clinical result of TED. In conclusion, NLR was correlated with CAS and MR imaging findings, and it was associated with a poor clini cal result of TED at a follow-up in patients with TED.

Source link: https://doi.org/https://doi.org/10.1530/EC-22-0260


Construction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis

Abstract Background: Thyroid eye disease is the most common orbital pathology affecting up to 50% of patients with Graves'u2019 disease. Results The GSE105149 and GSE58331 datasets were downloaded from the Gene Expression Omnibus database and merged for the purpose of determining TED-associated modules by weighted gene coexpression network analysis and local maximal quasi-clique merger analysis. The MCODE plugin enabled gene mapping to be performed using the intersection of genes obtained by WGCNA, lmQCM, and DEGs, as well as hub genes. Based on the similarity of 497 genes retrieved from the various approaches, a large TED coexpression network was established, and 11 genes were identified as hub genes. Genes in the coexpression network were enrichted in the biological processes that included proteasomal protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic pathway, as well as endocytosis and ubiquitin-mediated proteolysis, as well as endocytosis and ubiquitin-mediated proteolysis.

Source link: https://doi.org/10.1186/s40246-022-00412-0


Change of intraocular blood flow during treatment for thyroid eye disease

To publish a sequential observational study of changes in the retinal and choroidal blood flow during medical and surgical procedures for a thyroid eye disease patient using optical coherence tomography angiography and laser speckle flowgraphy. OD 20 mmHg and OS 24 mmHg were used in an intraocular pressure test. Thyrotropin receptor antibody and thyroid-stimulating antibody serum levels were 18. 8 IU/L and 434 percent, respectively. The patient underwent IV pulsed steroid therapy followed by an oral prednisone for one month. In both cases, bilateral orbital fat decompression decreased his final CAS score to 1 in both directions. The retinal blood flow increased marginally, but choroidal blood flow increased by a healthy amount. Both LSFG and OCTA results showed that Choroidal blood flow measured using both LSFG and OCTA was negatively correlated with both CAS rank and TRAb. The ocular perfusion, especially choroidal blood flow, may decrease in active TED, which can be reversed by medical and surgical therapy.

Source link: https://doi.org/10.4103/tjo.tjo_2_22


Minimally invasive surgery for thyroid eye disease

Proptosis, strabismus, eyelid retraction, optic neuropathy, soft tissue changes around the eye, and unstable ocular surface are all ways that thyroid eye disease can influence the eye in a variety of ways: proptosis, strabismus, eyelid retraction, optic neuropathy, optical neuropathy, soft tissue changes around the eye, and uneven ocular surface. Over the years, surgical techniques, not only the surgical techniques, but also the theories, and surgical tools are among the surgical instruments available. In the recent past, the indications for decompression surgery have also grown. This essay explores the technological and scientific advancements of minimally invasive surgery for TED, which have reduced risks and speed up recovery.

Source link: https://doi.org/10.4103/0301-4738.171967


Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study

Methods The control group participants, according to the cross-sectional study, were healthy people with no ocular abnormalities and were euthyroid. Patients with CAS scores 0 to u20132 were classified as group A, and group B with scores three or more as group B. In the TED group, the mean whole image AV VD and the mean whole image SVV D showed no statistical significant difference when compared to the control group. In the TED group, we observed a non-significant decrease in AV and SV radial peripapillary capillary VD. In CAS group B, there was a significant decline in the mean whole image AV VD and the mean whole image SV VD, as well as group A compared to group A. Conclusions Non-significant ONH vascular changes in patients with TED, including reduced VD of ONH in the radial peripapillary capillary, were not reported in the study. Patients with higher CAS scores had a more noticeable decrease in ONH microvasculature.

Source link: https://doi.org/10.1186/s13044-022-00134-4


Thyroid eye disease or Graves’ orbitopathy: What name to use, and why it matters

There is currently no universally recognized term for inflammatory disease of the eye and orbit related to thyroid autoimmune disease. Between 2000, 2010 and 2020 studies, 2,2 compare the frequency of various terms used for eye disease in the scientific literature between 2000, 2010, and 2020; 2. The methods used to analyze all English language papers published in PubMed, with publication dates in the years 2000, 2010, and 2020, which included one of six terms commonly used to describe eye disease inautoimmune thyroid disease. Between 2010 and 2020, thyroid eye disease became the most common condition, followed by Gravesu2019 Orbitopathy. This perspective paper recommends u201cthyroid eye disease u201d as the preferred term for this condition, and discusses terminology usage and trends in scientific literature and professional societies.

Source link: https://doi.org/10.3389/fendo.2022.1083886


Repurposing Lenvatinib as A Potential Therapeutic Agent against Thyroid Eye Disease by Suppressing Adipogenesis in Orbital Adipose Tissues

The most common orbital disease in adults is thyroid eye disease. We aimed to investigate the factors underlying OAT growth and find a drug targeting OAT in TED. In contrast to controls, we found an increasing number of adipocytes with smaller size in TED-derived OATs, contributing to OAT enlargement in TED, rather than hypertrophy. Enriched vascular endothelial growth factor receptor genes were discovered in adipocytes isolated from preadipocytes of the TED-derived stromal vascular fraction, according to a cellular fraction with a vascular fraction. Similarly, OATs in patients with TED showed a higher incidence of VEGFR-1 and -2.

Source link: https://doi.org/10.3390/ph15111305


Clinical efficacy of transcutaneous triamcinolone acetonide injection for upper eyelid retraction and swelling in patients with thyroid eye disease

Patients with thyroid eyelid retraction and swelling in thyroid eye disease patients can be evaluated by a case series. In addition, the LPS muscle, orbital, and retro-orbicularis oculi fat were all found using MRI before and after treatment. Results: Two patients had evidence of their upper lid retraction and swelling within 12 months. Eyelid swelling remained mild in the other patient with proptosis, eyelid retraction, and eyelid swelling faded, but eyelid swelling was not severe. Both high-intensity signals on T2 images and a longer T2 relaxation time were standardized in addition. Conclusion: Transcutaneous TA injection was safe for upper eyelid retraction and swelling in euthyroid TED patients with signs within six months before treatment. No adverse outcomes were observed.

Source link: https://doaj.org/article/bb173030fa1e4ed7befe617d1a9c168f

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions