Advanced searches left 3/3

Thrombophilia - Springer Nature

Summarized by Plex Scholar
Last Updated: 09 June 2022

* If you want to update the article please login/register

Secondary prophylaxis of venous thromboembolism with direct oral anticoagulants: comparison between patients with major congenital thrombophilia versus non-thrombophilic patients

"Congenital thrombophilia is a condition that leads to a higher risk of VTE and is often associated with long-term anticoagulation for secondary prophylaxis. " In patients with significant thrombophilia, it's less clear how DOACs are effective. In patients affected by major congenital thrombophilia in patients with a control group of patients with idiopathic recurrent VTE secondary prophylaxis with no thrombophilia, the aim of our study was to determine the safety and effectiveness of complete and reduced DOACs doses for VTE secondary prophylaxis in patients with a diagnosis of acute thrombophilia. We retrospectively evaluated consecutive patients for recurrent VTE, treated with DOACs, and compared the results between patients affected by major thrombophilia and the control group. Our results show that DOACs can be safe and safe in the secondary VTE prophylaxis in patients with significant congenital thrombophilia, as well as at reduced doses.

Source link: https://doi.org/10.1007/s11739-021-02917-3


The prognostic role of extended preoperative hypercoagulability work-up in high-risk microsurgical free flaps: a single-center retrospective case series of patients with heterozygotic factor V Leiden thrombophilia

"The authors explore and explore patient diagnosis and treatment with heterozygotic factor V Leiden thrombophilia undergoing free flap reconstruction. " Methods Between November 2009 and June 2018, 23 free flap surgeries were performed in 15 hypercoagulable patients with hFVL. Results in 14 free flap surgeries HFVL mutations had been reported preoperatively, in 14 free flap surgeries, but in nine free flap surgeries, mutations were only discovered postoperatively, after the occurrence of microvascular thromboses had justified extended hypercoagulability research. The overall incidence of intraoperative flap thromboses was 9%, but the overall rate of postoperative flap thromboses was 43 percent. Flaps with unconfirmed diagnosis prior to surgery were at ten times more likely to develop total necroses. Conclusions A meticulous preoperative work-up of patients with a history of hypercoagulability may help reduce free flap loss rates, thus improving surgical outcomes and increasing patient safety. ".

Source link: https://doi.org/10.1186/s12893-022-01639-3


Peripartum management of hereditary thrombophilia: results of primary surveillance in Japan

Antithrombin, protein C, and protein S deficiency were found in 84, 67, and 443 pregnancies, respectively, with incidence rates among total deliveries of 0. 12 percent, 0. 009%, and 0. 06 percent among total deliveries at 0. 012%, 0. 009%, and 0. 06 percent. " Both antigens and AT, PC, and PS use for the diagnosis of thrombophilia was 52%, and 46. 9% of hospitals did not perform gene analysis. In the ante- and postpartum care of patients with AT deficiency in 67. 1% and 63. 3 percent of hospitals, most commonly with 10,000 units of unfractionated heparin. ".

Source link: https://doi.org/10.1007/s12185-022-03354-4

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions