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Thrombophilia - Europe PMC

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Last Updated: 09 June 2022

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Low molecular weight heparin and pregnancy outcomes in women with inherited thrombophilia: A systematic review and meta-analysis.

"Aim To determine whether the use of low molecular weight heparin improves the pregnancy results in women with inherited thrombophilia by a meta-analysis of randomized controlled trials and observational studies. " Results showed that the use of LMWH was associated with a significantly higher rate of live birth as well as a significantly lower incidence of APOs in women with inherited thrombophilia in the meta-analysis of cohort studies. Conclusions The use of LMWH may have a potentially beneficial effect on reducing the risk of APOs and even raising the live birth rate in women with inherited thrombophilia. Further well-designed clinical trials with large samples are required to explore the role of LMWH in improving pregnancy outcomes among pregnant women with inherited thrombophilia. ".

Source link: https://europepmc.org/article/MED/35661489


Approach to Thrombophilia in Pregnancy-A Narrative Review.

"Genetic testing for thrombophilic gene mutations is performed using various techniques of real-time polymerase chain reaction and DNA microarrays of specific genes is evaluated. " The primary aim of this narrative review was to quantitatively evaluate the literature on pregnant women with thrombophilia that are at risk of experiencing unplanned miscarriages.

Source link: https://europepmc.org/article/MED/35630108


Retinal vein occlusion in patients under 50 years. Analysis of vascular risk factors, thrombophilia, carotid ultrasound findings and uncommon aetiologies.

"Introdution Retinal vein occlusion has been attributed to vascular risk factors and thrombophilia," the author says. Methods This is a prospective cohort analysis of all patients diagnosed with RVO and referred to an Internal Medicine clinic of a tertiary teaching hospital during a 10-year period. In young patients without cardiovascular risk factors, uncommon diseases related to RVO such as hepatitis C, thalassemia minor, Lyme disease, vaping, and periphlebitis were reported. Conclusion We recommend a genetic thrombophilia analysis in RVO patients younger than 50 years, although thorough monitoring of vascular risk factors is always recommended in all RVO patients. ".

Source link: https://europepmc.org/article/MED/35618638


The prognostic role of extended preoperative hypercoagulability work-up in high-risk microsurgical free flaps: a single-center retrospective case series of patients with heterozygotic factor V Leiden thrombophilia.

"The authors discuss their research and approach to diagnosing and treating patients with heterozygotic factor V Leiden thrombophilia undergoing free flap reconstruction. " Methods Between November 2009 and June 2018, 23 free flap surgeries were performed in 15 hypercoagulable patients with hFVL, which included hFVL in 15 hypercoagulable patients with hFVL. HFVL mutations had been reported preoperatively in 14 free flap surgeries, but in nine free flap surgeries, mutations were only detected postoperatively, after the occurrence of microvascular thromboses had warranted prolonged hypercoagulability work-up. The overall rate of intraoperative flap thromboses was 9%, while the overall rate of postoperative flap thromboses was 43 percent. Compared to others, flaps with unconfirmed diagnosis prior to surgery were ten times more likely to experience total necroses. Conclusions "Meticulous preoperative work-up of patients with a history of hypercoagulation can help decrease free flap loss rates, thereby improving surgical outcomes and improving patient safety. ".

Source link: https://europepmc.org/article/MED/35568862


Peripartum management of hereditary thrombophilia: results of primary surveillance in Japan.

Antithrombin, protein C, and protein S deficiency were found in 84, 67, and 443 pregnancies, respectively, with incidence rates among total delivery rates at 0. 012%, 0. 09%, and 0. 06 percent. " 50% of hospitals that tested both antigens and AT, PC, and PS activity for the diagnosis of thrombophilia was 52%, and 46. 9% of institutions did not perform gene analysis. If complete answers were given, there could be as many as 29, 23, and 151 every year in Japan with AT, PC, and PS deficiency.

Source link: https://europepmc.org/article/MED/35551617


Inherited thrombophilia transpires with severe coronary arterial thrombosis in wide range of age backgrounds: A report of 3 cases.

"Introduction and importance: Protein C and S deficiency are two of the coagulation cascade disorders that can also contribute to arterial thromboembolism, but not so often to arterial thromboembolism. " Here we have a summary of three severe coronary artery disease outbreaks affecting young to elderly patients with concomitant inherited thrombophilia. Case description The first case was a persistent coronary syndrome in a young male patient with a history of VTE without any other risk factor of CAD. In a young patient on supposedly effective double anti platelet agent, the third case was about increased atherosclerosis progression from previously non-important stenosis in RCA to complete occlusion in RCA and inferior STEMI. Patients with inherited thrombophilia are safe and effective, and they can be used as either prophylactic or therapeutic use in patients with inherited thrombophilia.

Source link: https://europepmc.org/article/MED/35600193

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions