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Thrombophilia - DOAJ

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Last Updated: 09 June 2022

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Systematic review: hereditary thrombophilia associated to pediatric strokes and cerebral palsy

"Objectives: This review sought to integrate and consolidate the latest information about mutations and genetic polymorphisms related to hereditary thrombophilia, as well as their potential association with pediatric stroke and cerebral palsy. " The results of hereditary thrombophilias and their connection to CP and arterial and venous pediatric stroke were mixed. Those with two or more hereditary thrombophilias, or the relationship between thrombophilia and other medical risk factors may be higher risk of CP and pediatric stroke than isolated hereditary thrombophilia. Conclusions: Larger, multicenter studies should be developed in order to better clarify the role of mutations that cause hereditary thrombophilia and the development of CP and pediatric stroke. Dados de su00e1ficas nas dados e nas referee de dados eta de u00e3o definitive 75 artigos como eta revisu00e3o dados. http://www. u00e3o. com u00e3o Apes dados de dados eta dados de dados de e3o e3os e3o de compliante3o e tu00e e e3o e1e tas dna de do e3o u00e3o e3o o e3o o nas o dnas de o s u00e3o tas o Os etu00e1 centos arteriais e venosos aprovedos demoos deob vs. 00e7: mf3es aos morrias hereditary, etas e suas resultados contraditu00e3rios arteriais e venosos e f3e e1e e7e e1e7e1e1e e1e e as e ae e e1e e e1e e e7e e e1e e3e e5e5e e as e e1rias e3e e4e5e e3e e1 A00e7, a descompuls men especu00es cl edfos de trombofilias hereditary isoladas, plus a jun00e1rias, pu00e1mu00e3o de tremo de elu00e1rias, a de Aristo. u00e07o de duas ou mais trombofilias hereditary as e1tu00e e1tu00e1rias e e1rias e e1rias e3o de e u00e1rias e1rias as e1rias e e1rias u00e1rias e1rias Conclus de grande porte devem elucidar o papel real. 00e5es defi 5es deceive o papel real o papel real yeu00e5es etu00e6es eta lu00e5es etias hereditary etias jugabe1rias comada et AVC torna e difu00edcil defa es, os benefu00etu00e1veis, por u00e3m calculu00e1veis. ".

Source link: https://doi.org/10.1016/j.jped.2014.08.004


Breus’ Mole Associated with Hereditary Thrombophilia in A Teenage Girl

"Breus” u2019 mole is a rare occurrence, and it is most often found in the placenta of stillborn fetuses. After 2 months amenorrhea, a 17-year-old woman with no previous gravida was admitted to our clinic with intermittent vaginal bleeding and lower abdominal pain. Serum u03b2-human chorionic gonadotropin was rated as 33096 U/ml by the Serum 30496 U. ml. Due to the diagnosis of molar pregnancy, Suction curettage was not administered. In the patient, a factor V leiden gene mutation was found in the patient. Patients with Breusu2019mole should be screened for hereditary thrombophilia," said Grebsia in differential diagnosis of early gestational disorders.

Source link: https://doaj.org/article/81e83c7f4c02441096cd1ca7e3f88aef


Approach to Thrombophilia in Pregnancy—A Narrative Review

"Using different techniques of real-time polymerase chain reaction and DNA microarrays of specific genes, genetic testing for thrombophilic gene mutations is performed. " The primary aim of this narrative review was to quantitatively review the literature on the specific care of pregnant women with thrombophilia who are at risk of suffering unplanned miscarriages.

Source link: https://doi.org/10.3390/medicina58050692


The prognostic role of extended preoperative hypercoagulability work-up in high-risk microsurgical free flaps: a single-center retrospective case series of patients with heterozygotic factor V Leiden thrombophilia

"The authors introduce their research and approach to diagnosing and treating patients with heterozygotic factor V Leiden thrombophilia (free flap reconstruction). Methods Between November 2009 and June 2018, 23 free flap surgeries were performed in 15 hypercoagulable patients with hFVL. HFVL mutations had been reported preoperatively in 14 free flap surgeries, but in nine free flap surgeries, mutations were only detected postoperatively, after the occurrence of microvascular thromboses had been warranted for prolonged hypercoagulability work-up. The overall prevalence of intraoperative flap thromboses was 9%, but the overall rate of postoperative flap thromboses was 43 percent. Compared to others, flaps with unconfirmed diagnosis prior to surgery were ten times more likely to experience total necroses. Conclusions "Meticulous preoperative work-up of patients with a history of hypercoagulability may help minimize free flap loss rates, improving surgical outcomes and raising patient safety. ".

Source link: https://doi.org/10.1186/s12893-022-01639-3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions