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Testicular Torsion - PubAg

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Last Updated: 16 October 2021

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Acetyl-11-keto-β-boswellic acid prevents testicular torsion/detorsion injury in rats by modulating 5-LOX/LTB4 and p38-MAPK/JNK/Bax/Caspase-3 pathways

Testicular torsion/detorsion is a crucial medical condition that demands punctual medical intervention to stay clear of testicular atrophy and the inability to conceive. Interestingly, acetyl-11-keto-β-boswellic acid, the major active component of Boswellia material, has shown potent repressive impact on 5-lipoxygenase enzyme which transforms arachidonic acid into inflammatory moderators. Therefore, this study was performed to examine the protective mechanisms through which AKBA may protect against testicular T/D injury in rats. Male rats were arbitrarily dispersed into 5 groups: Sham, AKBA, unilateral testicular T/D, AKBA at two dose levels adhered to by T/D. These results were accompanied with ATP replenishment and DNA conservation, resulting inevitably in salvage of the testis. Unprecedentedly, the existing mechanistic research revealed the pathways by which AKBA may hinder testicular T/D injury and supplied a novel safety method that may attenuate the seriousness of this condition.

Source link: https://pubag.nal.usda.gov/catalog/7130611


Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism

Oxidative anxiety following testicular torsion plays an important function in the ýonset and growth of apoptotic cell fatality via dysregulation of the cellular signaling paths. In present work, we evaluated the duty of the mammalian target of rapamycin in antioxidant result of capsaicin against reperfusion injury complying with testicular torsion. Male Wistar rats considering 200-- 220 g were arbitrarily appointed into four major teams: a sham ran team, a testicular torsion team, three teams treated with various doses of capsaicin, and three groups of healthy and balanced rats treated with various doses of capsaicin. Western blotting assay was utilized to take a look at the anti-apoptotic impacts of capsaicin in testicular cells complying with torsion. Capsaicin administration extremely reduced the phosphorylation of mTOR at the greatest dose. Capsaicin decreased apoptosis and preserved tubular morphology in testes. Our outcomes showed that antioxidant properties of capsaicin minimizes cell fatality and reperfusion injury complying with testicular torsion.

Source link: https://pubag.nal.usda.gov/catalog/5933873


Nesfatin-1 ameliorates testicular injury and supports gonadal function in rats induced with testis torsion

In the here and now research study, we aimed to investigate the putative helpful results of nesfatin-1 on oxidative injury and impaired testicular function generated by testis torsion. Under anesthesia, male Sprague-Dawley rats had sham-operation or they undertook testicular torsion by rotating the left testis 720 ° and fixing it for 2 h, adhered to by a 2-h detorsion. In saline-treated torsion/detorsion team, a high portion of uncommon spermatozoa with head issues was observed, which was eliminated in nesfatin-1-treated torsion/detorsion team. The degrees of 8-OHdG, lump death factor -alpha, interleukin -6, caspase-3 were boosted in the saline-treated torsion/detorsion group as contrasted to sham-operated group, while nesfatin-1 pre-treatment substantially decreased the expressions of the pro-inflammatory cytokines, depressed apoptosis, and minimized the tubular deterioration. On top of that, nesfatin-1 in torsion/detorsion team boosted expressions of changing development element -beta and lowered expressions of healthy protein kinase B and cAMP response element binding healthy protein in the testis tissue.

Source link: https://pubag.nal.usda.gov/catalog/6102071


Protective effects of polydatin on experimental testicular torsion and detorsion injury in rats

Oxidative tension plays a vital function in the process of testicular torsion and detorsion. The purpose of the existing research study was to investigate the protective effect of polydatin on testicular T/D injury. Rats were arbitrarily divided into three groups, a sham group, a group based on 2h torsion adhered to by 24h detorsion and a team based on T/D and injected i. p. Compared with the T/D team, PD pretreatment substantially ameliorated the morphological damage, lowered the Cosentino histological score and raised the mean number of germ cell layers and Johnsen's testicular biopsy rating. Furthermore, PD treatment significantly decreased MDA levels and upregulated GPx, cat and sod task. Moreover, PD decreased T/D-induced germ cell-specific apoptosis, undermined the activation of caspase-3, caspase-9, caspase-8 and poly polymerase and increased the Bcl-2/ Bax ratio.

Source link: https://pubag.nal.usda.gov/catalog/5850290


Effect of Zinc and Melatonin on Oxidative Stress and Serum Inhibin-B Levels in a Rat Testicular Torsion–Detorsion Model

The here and now research study was intended to check out the results of 3-week zinc and melatonin administration on testicular cells injury and lotion Inhibin-B degrees caused by unilateral testicular torsion-- detorsion in rats. Testicular torsion-- detorsion treatments included anemia for 1 h and afterwards reperfusion for another hr of the left testis. Blood and testicular tissue examples were accumulated to evaluate erythrocyte and tissue GSH and plasma and cells MDA, Inhibin-B levels. The greatest erythrocyte and testis GSH worths were discovered in zinc, and melatonin + melatonin teams. Product inhibin-B and spermatogenic activity levels in the torsion-- detorsion group were substantially less than those in the various other groups. The results of the research study reveal that melatonin, and zinc + zinc administration partially brings back the boosted oxidative anxiety, as well as the reduced inhibin-B and spermatogenic task levels in testes anemia-- reperfusion in rats.

Source link: https://pubag.nal.usda.gov/catalog/5863087


Psoralea corylifolia protects against testicular torsion/detorsion-induced ischemia/reperfusion injury

During testicular ischemia and reperfusion, overgeneration of responsive oxygen varieties is a major launching component of the testicular spermatogenic injury. Psoralea corylifolia, a medical natural herb with anti-oxidative task, has been utilized to deal with male reproductive dysfunction in typical Chinese medicine. In this research study, we investigated the result of Psoralea corylifolia on testicular torsion/detorsion-induced injury. MATERIALS AND METHODS: Sixty grown-up male Sprague-Dawley rats were randomly split into 3 teams, each having 20 rats. Rats in the treatment team got the very same procedure as the torsion-- detorsion group, but Psoralea corylifolia was administered orally. Bilateral orchiectomy was carried out on fifty percent of the rats in each experimental team at 4h after detorsion for measurement of malondialdehyde which is an indication of intratesticular responsive oxygen varieties content. FINAL THOUGHTS: These outcomes suggest that Psoralea corylifolia might protect testicular spermatogenesis by enhancing CREMτ expression by scavenging reactive oxygen varieties.

Source link: https://pubag.nal.usda.gov/catalog/478438


Investigating the sperm parameters, oxidative stress and histopathological effects of salvia miltiorrhiza hydroalcoholic extract in the prevention of testicular ischemia reperfusion damage in rats

Salvia miltiorrhiza hydroalcoholic extract possess high antioxidant properties, and its efficiency in ischemia-reperfusion injury prevention has been demonstrated in cardiac, renal, and liver cells. For that reason, the purpose of this study was to examine the safety mechanism of SM extract on testicular I/R damage. 18 fully grown male Wistar albino rats were randomly split into 3 teams; with six rats in each group: Group 1 was sham-operated. Induction of testicular T-D caused a significant increment in the level of MDA and significant decrease in the levels of CAT, gpx, and tac both in plasma and testis cells, whereas administration of SM remove significantly lowered MDA level and enhanced GPX, CAT, and TAC degrees in plasma and testicular cells.

Source link: https://pubag.nal.usda.gov/catalog/6804814


Testicular torsion and its effects on the spermatogenic cycle in the contralateral testis of the rat

The purpose of the existing study was to examine the results of independent testicular torsion on the contralateral testis relative to the phases of the cycle of the seminiferous epithelium. Groups 6-10 had unilateral orchiectomies after unilateral testicular torsion for 3 to 48 h. Animals constituting team 11 served as the control sham-operated group. These results reveal that phases VI-XI of the spermatogenic cycle, the stages connected with reduced antioxidant capabilities, are one of the most sensitive to the effects of testicular torsion on the contralateral testis.

Source link: https://pubag.nal.usda.gov/catalog/6246635


Mechanism mediating the protective effect of diacerein in ischemia-reperfusion-induced testicular injury in rats

Torsion of the spermatic cable is an usual urologic emergency and can bring about testicular death and infertility. We aimed to explore the function and mechanism of action of DIA in generated TIR. DIA was provided i. m to rats in the visibility or absence of TIR. Histopathology and interleukin1b immunoexpression were evaluated. TIR materialized by substantial decrease in testicular weight, lotion testosterone and testicular cells GSH degrees and SOD activity along with rise in product total cholesterol, testicular MDA and NOx levels. TIR revealed the histopathological adjustments of significant testicular damages with boost in IL-1b immunoexpression. DIA was able to normalize both testicular weight, serum testosterone and cholesterol levels with attenuation of oxidative anxiety criteria along with amelioration of histopathological modifications and IL-1 b immunostaining induced by TIR. DIA has a protective result versus TIR induced injury in rats mediated by its anti-inflammatory and anti-oxidant tasks.

Source link: https://pubag.nal.usda.gov/catalog/6103418


The protective effect of low-energy shock wave on testicular ischemia-reperfusion injury is mediated by the PI3K/AKT/NRF2 pathway

Testicular ischemia-reperfusion injury is the primary pathophysiological consequence of testicular torsion. Low-energy shock wave is an effective treatment for sure illness. Today research checked out whether LESW can boost on testicular IR injury in rats and checked out the involved mechanism. Testicular reperfusion was generated in rats after 1-h anemia. The first LESW treatment was carried out 30 minutes before testicular reperfusion, and then every various other day for another 3 applications. LESW upregulated the phosphorylation levels of AKT and glycogen synthase kinase 3β. LESW additionally upregulated VEGF-A degree in rats with testicular IR injury. This study demonstrated that LESW can relieve testicular IR injury in rats, which could be attributed to the activation of PI3K/AKT/NRF2 pathway. These searchings for recommended the possibility of LESW in the treatment of testicular torsion.

Source link: https://pubag.nal.usda.gov/catalog/6176084

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions