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Patients with relapsed and refractory lymphomas were enrolled in a multicenter phase I/III study that compared TEM/LEN and TEM/LEN in patients with relapsed and refractory lymphomas. There were 18 patients in the phase I dose-finding study, and TEM 25 mg weekly and LEN 20 mg daily were the recommended phase II dose for day 1 and day 21. The majority of patients were accepted in the phase II cohort, which included diffuse large B-cell lymphoma, follicular lymphoma, and an exploratory cohort of other lymphoma histologies with classical Hodgkin lymphoma. Patients with cHL were highly supervised with a median of four prior treatments and one-third with relapse after autologous stem cell transplantation; patients with cHL had a median of six prior therapies. Following TEM/LEN therapy, eight cHL patients progressed to allogeneic transplantation.
Source link: https://europepmc.org/article/MED/34320785
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